Re: RE: please help (and family tree idea)

[Guest guest]

> Regarding your comment, Rob: females with BPES are generally

> infertile due

> to ovarian

> failure at an early age,

>

> The word " generally " is a bit misleading. It is possible for some

> femaleswith BPES to have children. I have to say I would not use

> the word

> " generally " in the same way that you have done.

I have to say, I totally agree, this can be misleading. I have been given the

impression that there is not nearly enough research into BPES to make any

general comments such as this. They do not even have evidence that 100% of the

children affected have the same mutated gene. This being said, in my opinion,

there are just too many differences in our children at this point to make any

general statements about things such as infertility. I guess all we can say at

this point is that it could be a possibility in the future for any of our girls,

because we know it has happened to others.

Also, in as much as I know about genetics (which I admit is not nearly

enough)...how would it be possible that a woman would have a 90 some % chance of

passing it on when there would be a chance that the child gets the " good " gene

from the other parent? I think we know at least that the " mutated " gene is not

dominant therefor it would only make sense that the 50% rule would ring true.

Thanks for putting the family tree stuff together it's neat to see.

Trish