Guest guest Posted May 3, 2006 Report Share Posted May 3, 2006 An observational trial was performed after the anthrax letter attacks. A total of 30,000 people were thought to have been potentially exposed and were offered antibiotics and vaccine. 10,000 plus took antibiotics and 199 took 3 doses of vaccine as well post exposure. None of them came down with anthrax. Thus rapid antibiotic use was associated with 100% disease prevention, and vaccination confirmed no additional benefit. Meryl Nass, MD > ----------------------------------------------------------------------- > --------- > WASHINGTON (Reuters) MAY 1, 2006 504 PM ET > Vaccine plus antibiotics protects against anthrax By Maggie Fox, > Health and Science Correspondent > Mon May 1, 5:04 PM ET > > > > WASHINGTON (Reuters) - Combining an anthrax vaccine with a short > course of antibiotics completely protected monkeys who inhaled spores > of the often-deadly bacteria, offering perhaps a more realistic way to > protect people in case of a biological attack, researchers said on > Monday. > > > > The finding suggests it may be possible to vaccinate people who have > been exposed to anthrax spores, and give them a short, two-week course > of antibiotics to provide extra protection while their immune system > gears up, the researchers report in this week's issue of the > Proceedings of the National Academy of Sciences. > > This could be a more useful way to treat people who are exposed to > inhaled anthrax than the current regime of taking antibiotics every > day for two months, the team at the U.S. Army Medical Research > Institute of Infectious Diseases and the National Institute of Allergy > and Infectious Diseases said. > > " This provides direct evidence that the combination of anthrax vaccine > with a short course of antibiotics given post exposure can completely > protect nonhuman primates from inhalational anthrax, " said Dr. Arthur > Friedlander, who led the study. > > " Our results also suggest that the appearance of an antibody response > -- after treatment with antibiotics alone or in conjunction with > vaccination -- might be useful in determining when antibiotics can be > safely discontinued. " > > In October 2001, someone sent several letters contaminated with > anthrax spores to several U.S. offices, including at the Senate in > Washington. > > Eleven people became infected with inhalational anthrax, the most > deadly form, and five of them died. No one has ever been charged with > the crime. > > INHALED DANGER > > Inhaled anthrax is dangerous because it can form spores that lodge in > the lungs and become dormant weeks after the initial exposure. > > If someone knows he or she has been exposed, anthrax is easily treated > with antibiotics, but once the symptoms of inhaled anthrax begin it is > almost impossible to treat because the bacteria have already pumped > out lethal amounts of toxin. > > So after the 2001 attacks, more than 10,000 people who may have been > exposed to the spores, notably employees of the U.S. Senate and some > postal workers, were offered a 60-day course of ciprofloxacin or > doxycycline, the two antibiotics that can prevent anthrax symptoms. > > But it is difficult to take antibiotics for such a long time and there > are significant side effects. > > " Adverse events associated with antibiotic prophylaxis such as > diarrhea, nausea, vomiting, and dizziness were commonly reported, " the > researchers wrote. > > " More importantly, the overall adherence rate during 60 days of > antibiotics was poor (44 percent), " they added. > > So the researchers tested two groups of 10 rhesus macaques each, > exposing them to a lethal dose of anthrax spores and then giving them > 14 days worth of antibiotics. > > " One group also received three doses of the licensed human anthrax > vaccine, " the researchers wrote. > > Only four monkeys given antibiotics alone lived, compared to all 10 > who got the vaccine also. > > And the animals were immune to anthrax eight to 11 months later, > suggesting long-term benefit from the vaccine, the researchers said. > > > > > > Our Anthrax information web site: > http://www.dallasnw.quik.com/cyberella/ > /files/VAERS.pdf > DESTROY QUARANTINED VACCINE: > http://www.PetitionOnline.com/mod_perl/signed.cgi?robi2662 & amp;amp; > amp;amp;1 > PETITION TO OVERTURN/REPEAL FERES DOCTRINE > http://www.petitiononline.com/fd1950/petition.html > To visit Dr. Meryl Nass's web site, go to: > http://www.anthraxvaccine.org > Also visit: Anthrax Vaccine Benefit vs Risk: http://www.avip2001.net > AND http://www.MajorBates.com/ > Anthrax Vaccine Network http://www.ngwrc.org/anthrax/default.asp > Sgt. Larson's story: > http://www.ngwrc.org/anthrax/heroes/sandralarson.htm > http://www.avip2001.net/CongressionalTestimony.htm > Tom Heemstra's new book - > http://www.anthraxadeadlyshotinthedark.com/index.html > Contact list owner: Gretchen at: anna_nim@... > Quote Link to comment Share on other sites More sharing options...
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