Clearing up a point (Type I and Type II)

[Guest guest]

Hi everyoneI have contacted Dr Oley and have asked her to explain something to me, which I have copied below.I hope to be able to get some more information from her and post it on this site.RegardsShireen-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------> From: Oley> Sent: 12 October 2005 08:17> andy.bowles@...> Subject: RE: That question>> Thanks Shireen.> In the article I quote a paper from Zlotogora in 1983 which> talks about the different sex ratios. But I don't think that> information has ever been clarified since, so I don't think> it should be quoted now. > The situation now is: Type I -

> 1 in 2 risk of males with type I having affected children, both girls and boys. If females> with type I are able to have children, then they have 1 in 2 risk to both boys and girls.

> Males and females with Type II

> have 1 in 2 risk to both girls and boys.

> I haven't seen any recent papers which talks about skewing of the sex ratios.> I hope this answers your query.> Best wishes,> Chris>> Dr Oley> Consultant Clinical Geneticist> Clinical Genetics Unit> Birmingham Women's Hospital> Metchley Park Road> Edgbaston> Birmingham> UK B15 2TG

[Guest guest]

Thank you for doing this Shireen. The info didn't seem accurate and

this clears it up. Appreciate your efforts!

>

> Hi everyone

> I have contacted Dr Oley and have asked her to explain something to

me,

> which I have copied below.

> I hope to be able to get some more information from her and post it

on this

> site.

> Regards

> Shireen

> --------------------------------------------------------------------

--------

> --------------------------------------------------------------------

--------

> -----------------------------------------------------------

>

> > From: Oley

> > Sent: 12 October 2005 08:17

> > andy.bowles@v...

> > Subject: RE: That question

> >

> > Thanks Shireen.

>

> > In the article I quote a paper from Zlotogora in 1983 which

> > talks about the different sex ratios. But I don't think that

> > information has ever been clarified since, so I don't think

> > it should be quoted now.

>

> > The situation now is: Type I -

>

> > 1 in 2 risk of males with type I having affected children, both

girls and

> boys. If females

> > with type I are able to have children, then they have 1 in 2 risk

to both

> boys and girls.

>

>

>

> > Males and females with Type II

>

> > have 1 in 2 risk to both girls and boys.

>

> > I haven't seen any recent papers which talks about skewing of the

sex

> ratios.

>

> > I hope this answers your query.

> > Best wishes,

> > Chris

> >

> > Dr Oley

> > Consultant Clinical Geneticist

> > Clinical Genetics Unit

> > Birmingham Women's Hospital

> > Metchley Park Road

> > Edgbaston

> > Birmingham

> > UK B15 2TG

>

[Guest guest]

Hi all

I posted this piece of information last year. Since the subject has come up again, I thought it would be worthwhile posting it again.

As you can see, it is pretty clear.

Regards

Shireen

ps - for those who are not familiar with Dr Oley, she is one of leading experts in the world on BPES (she is a genetics doctor)

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ From: OleySent: 12 October 2005 08:17andy.bowles@...Subject: RE: That question>In the article I quote a paper from Zlotogora in 1983 whichtalks about the different sex ratios. But I don't think thatinformation has ever been clarified since, so I don't thinkit should be quoted now. The situation now is: Type I -

1 in 2 risk of males with type I having affected children, both girls and boys. If femaleswith type I are able to have children, then they have 1 in 2 risk to both boys and girls.

Males and females with Type II

have 1 in 2 risk to both girls and boys. I haven't seen any recent papers which talks about skewing of the sex ratios.I hope this answers your query.Best wishes,ChrisDr OleyConsultant Clinical GeneticistClinical Genetics UnitBirmingham Women's HospitalMetchley Park RoadEdgbastonBirminghamUK B15 2TG