Fw: [interven] Re: Lipoic Acid (ALA) beginner questions

[Guest guest]

Posting from my friend Williss, my 80 year old expert LOL

Kathy

Re: [interven] Re: [ ] Lipoic Acid (ALA) beginner

questions

Dear Kathy:

Please post this to the autism treatment list for Beverly to see.

Regardless of what substance is used. Some will be adverse to it. We

shouldn't throw out the baby with the bath water as the old saying goes. I

was perhaps among the early ones to warn about chelating dangers on the

autism boards. ALA is a natural body substance necessary to body health and

well being. It is formed naturally in the body. You may well be dead without

it. That doesn't mean everyone can or should supplement it, though it can be

very beneficial, and has been proven to do some wonderful things in way of

antioxidant, and in protecting against diabetic problems.

That said, what are the considerations about its judicious supplementation

in

autism? First, know that ALA is a sulfur-bearing substance the same as NAC.

If you can't tolerate the one you will likely not tolerate the other. That

is

because ALA/NAC both supply cysteine. Due to a failure of the sulfating

circuit to break down Cysteine to taurine and to sulfate one can be cysteine

poisoned/toxic. The result is what Kathy's children experienced on

Immunocal™--which BTW, is a very fine product, and beneficial to many, but

not to PST types most probably. So, when used judiciously, ALA is beneficial

to all except those who cannot handle sulfur. The usual rule is 1/2 mg per

pound of body weight, but not more than 100 mg per dose. The best dose is 25

to 50 mg for children. I opt for the smaller.

There is another class of kids that should not use high doses of ALA. There

is compelling scientific evidence that high and constant doses of lipoic

acid

have the potential to seriously disrupt a number of key minerals including

copper, zinc, and molybdenum, possibly elevating copper or zinc to

potentially toxic levels. Do not use ALA if known to have high levels of

these minerals, or high levels of cysteine. If one has high levels of

methyl-mercury (inorganic mercury from fish), ALA can hurt as well.

Whether ALA by itself just moves mercury around, I don't know, but it is

generally thought best to give it some help in clearing the stuff it has

released. The combination of DMSA/ALA does that effectively.

Remember, DMSA is not candy. It is potentially damaging to some kids who

can't handle sulfur well. That is why one must use low dose, around the

clock

protocol. Furthermore, one should make sure the child has been taking a good

multivitamin mineral supplement for some time before chelating. Those PST

types, should be sure to supplement molybdenum to help insure they can

handle

the sulfur better. A little histidine would probably be in order. It is a

powerful chelator too, but these two supplements benefit the sulfur handling

circuit. Long term use of histidine could delete zinc and copper.

Now, as to Beverly's children's response. It is likely a normal detox

response. I questioned Dr. Amy Holmes at length about her experiences with

200 children and with Mikey, her son, in particular. She had used several

courses of DMSA until there was no more mercury seen in the urine. Then she

began Phase II detox: DMSA/ALA low-dose, around-the-clock dosing. Her words

were, " The mercury came pouring out of him again " . It continues to do so

several rounds later. DMSA removes only the loosely bound mercury, ALA

removes the tightly bound, particularly that in the brain, which DMSA will

not remove. Amy mentioned regression and hyperness during the dosing, with

definite gains seen in the rest periods. This is one game where there is no

gain without pain, yet one should rightfully be watchful for more negative

response than is typical. The regression and hyperness Beverly mentioned

seems to me to be normal detoxification reaction. It goes away during the

rest period, and the beneficial gains are then apparent.

In loving care

Willis

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