Re: increased risk of getting leukemia... any tips on preventing this?

[Guest guest]

One thing I had read, and its very easy to 'google' , is pesticide/herbicide exposure carries a higher risk of leukemia. Since I want to reduce her risk, our yard is stunning in the spring with an acre of yellow dandelions ( among other weeds of course) and a buzz with insects!!! Carol in IL AIM doihavtasay1 GigaTribe doihavtasayMom to seven including , 7 with TOF, AVcanal, GERD, LS, Asthma, subglottal stenosis, and DS.My problem is not how I look. It's how you see me. Join our Down Syndrome information group - Down Syndrome Treatment/ Listen to oldest dd's

music http://www.myspace.com/vennamusic----- Original Message ----From: Simone Mueller- <smueller00@...>Down Syndrome Treatment Sent: Saturday, January 5, 2008 12:37:02 PMSubject: increased risk of getting leukemia... any tips on preventing this?

Hi Qadoshyah:

Do you do anything special for your child to prevent the increased

risk? I would be very interested. I will be talking to a

Pediatrician who specializes in Special Needs kids nutrition. But I

would love some more input.

Simone

Mom of Ana 20 months.

>

> > >

> > > y Maggie Fox, Health and Science Editor

> > >

> > > WASHINGTON (Reuters) - People with Down's syndrome suffer

> cancer

> > less than

> > > most other people and a study in mice published on Wednesday

> gives

> > one

> > > possible explanation -- they produce higher levels of a

certain

> > protein.

> > >

> > > The protein may keep tumours from growing, and this finding

may

> > help in the

> > > development of new cancer drugs, the team at s Hopkins

> > University in

> > > Baltimore reported.

> > >

> > > Dr. Reeves of s Hopkins and colleagues found a

gene

> > called Ets2

> > > protected mice from colon cancer. Writing in the journal

> Nature,

> > Reeves and

> > > colleagues said they used mice bred to develop colon cancer

at

> > extreme

> > > rates, and genetically engineered them to produce extra

amounts

> of

> > Ets2.

> > >

> > > They said the more Ets2 the mice had, the less likely they

were

> to

> > develop

> > > colon cancer.

> > >

> > > The secret lies in having an extra copy of chromosome 21.

> People

> > with Down's

> > > syndrome, also known as Down syndrome, have three copies of

the

> > chromosome

> > > instead of the usual two.

> > >

> > > That gives them extra copies of all the genes on chromosome

21

> and

> > of the

> > > proteins that these genes produce.

> > >

> > > The effects are well known -- people with Down's suffer from

> mental

> > > retardation, have distinct facial and other physical

> > characteristics and a

> > > higher risk of some diseases.

> > >

> > > But not cancer, said Dr. Judah Folkman, a cancer expert at

> > Children's

> > > Hospital and Harvard Medical School in Boston. Ets2, which

is

> > found on

> > > chromosome 21, may help explain why.

> > >

> > > "They are protected against cancer and also atherosclerosis

and

> > diabetic

> > > retinopathy, " Folkman, who was not associated with the

> research,

> > said in a

> > > telephone interview.

> > >

> > > Diabetic retinopathy can cause blindness in people with

> diabetes

> > and, like

> > > atherosclerosis, is associated with blood vessel function.

> > >

> > > STARVING TUMORS

> > >

> > > Folkman discovered a protein called endostatin that kick-

> started a

> > field of

> > > cancer drugs called angiogenesis inhibitors. They starve a

> tumour

> > by

> > > stopping it from creating blood vessels to nourish itself.

> > >

> > > The basic biological mechanism, which affects blood vessel

> > function and

> > > growth, may also underlie other so-called vascular diseases

> such as

> > > atherosclerosis, Folkman said.

> > >

> > > Folkman and other researchers believe people with Down's

> produce

> > extra

> > > endostatin naturally, but also that other genes play an

> important

> > role. Ets2

> > > appears to be one of them.

> > >

> > > "It is turning out to be very important because it gives a

> strong

> > clinical

> > > clue that suggests some humans may be protected against

> cancer,"

> > Folkman

> > > said.

> > >

> > > "Down syndrome is always considered a tragedy for families.

But

> on

> > the other

> > > hand, they bring this huge clinical clue," Folkman said. The

> genes

> > that

> > > protect against cancer appear to be separate from the genes

> known

> > to cause

> > > mental retardation, he added.

> > >

> > > "In medical school in 1953 we were taught -- 'oh, by the

way,

> Down

> > syndrome

> > > individuals are protected against cancer'. Everybody asked

why

> and

> > they

> > > said, 'We think it is because they don't live long enough

(to

> > develop it),'"

> > > Folkman said.

> > >

> > > But now Down's patients live into their 70s and they still

> develop

> > cancer at

> > > a lower rate, he said.

> > >

> > > Dr. Threadgill of the University of North Carolina

agreed

> > that Ets2

> > > might be used as the basis of a drug, but said far more

> research

> > is needed

> > > because the protein also appears to help cancer spread, or

> > metastasize, when

> > > it does develop.

> > >

> > > "So therapeutic use of potential drugs with Ets2-like

activity

> to

> > reduce

> > > tumour incidence may have limited value, because a side

effect

> of

> > such drugs

> > > could be increased efficiency of metastasis," Threadgill

wrote

> in a

> > > commentary. (Editing by Alan Elsner)

> > >

> > > http://uk.reuters. com/article/ topNews/idUKN026 4850120080102?

> sp=true

> > >

> >

> >

> >

> >

> >

> >

> > ------------ --------- --------- --------- --------- --------- -

> ----------

> >

> >

> > No virus found in this incoming message.

> > Checked by AVG Free Edition.

> > Version: 7.5.516 / Virus Database: 269.17.13/1208 - Release

Date:

> 1/3/2008 3:52 PM

> >

>

>

>

>

>

>

> ------------ --------- --------- --------- --------- --------- -

-----------

>

>

> No virus found in this incoming message.

> Checked by AVG Free Edition.

> Version: 7.5.516 / Virus Database: 269.17.13/1209 - Release

Date: 1/4/2008 12:05 PM

>

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[Guest guest]

Hi Simone,

We give my brother Nutrivene-D and several other antioxidants (turmeric, blueberries, tart cherry, etc). We also give him MethylB12 and TMG to help with his homocysteine and MCV levels. If the MCV gets too high, it can lead to leukemia. The MCV is typically higher in DS due to the overexpression of the CBS gene. We give all this to him for many reasons, but hopefully it'll help prevent something like leukemia.

The exact ways of how leukemia is brought on is not understood really. Oxidative stress is involved in the pathogenesis of leukemia. Messed up folate cycles has also been seen in the pathogenesis of leukemia. To what extent all this is involved in the pathogenesis of leukemia is not completely understood, but it is involved somehow!

Proper nutrition is really important for everybody, but especially people with DS, because they have problems caused by the extra genes on the 21st chromosome, that people without DS don't have.

We give my brother Nutrivene-D, DHA, extra zinc, TMG, Methylcobalamin B12, and Ginkgo Biloba. All of this has helped him tremendously and it is great for him. We also try to feed him healthy foods. He will eat just about anything, but he really likes to eat yogurt and drink milk (we have our own goats and a cow for the purpose of raw milk). We always try to have yogurt on hand for him to eat whenever he asks to eat. We also buy dried blueberries for him only (since they are kind of pricey!).

Alot of pediatricians don't agree with Nutrivene-D (it is a supplement specifically targeted for people with DS, because their metabolic needs are different than the general population) for whatever reason, unfortunately.

I know a went a little further than just your question .

Qadoshyah

Book ~ Down Syndrome: What You CAN Dowww.gotdownsyndrome.net/Book/whatyoucandobook.html

increased risk of getting leukemia... any tips on preventing this?

Hi Qadoshyah:Do you do anything special for your child to prevent the increased risk? I would be very interested. I will be talking to a Pediatrician who specializes in Special Needs kids nutrition. But I would love some more input.SimoneMom of Ana 20 months.> > > >> > > y Maggie Fox, Health and Science Editor> > > > > > WASHINGTON (Reuters) - People with Down's syndrome suffer > cancer > > less than> > > most other people and a study in mice published on Wednesday > gives > > one> > > possible explanation -- they produce higher levels of a certain > > protein.> > > > > > The protein may keep tumours from growing, and this finding may > > help in the> > > development of new cancer drugs, the team at s Hopkins > > University in> > > Baltimore reported.> > > > > > Dr. Reeves of s Hopkins and colleagues found a gene > > called Ets2> > > protected mice from colon cancer. Writing in the journal > Nature, > > Reeves and> > > colleagues said they used mice bred to develop colon cancer at > > extreme> > > rates, and genetically engineered them to produce extra amounts > of > > Ets2.> > > > > > They said the more Ets2 the mice had, the less likely they were > to > > develop> > > colon cancer.> > > > > > The secret lies in having an extra copy of chromosome 21. > People > > with Down's> > > syndrome, also known as Down syndrome, have three copies of the > > chromosome> > > instead of the usual two.> > > > > > That gives them extra copies of all the genes on chromosome 21 > and > > of the> > > proteins that these genes produce.> > > > > > The effects are well known -- people with Down's suffer from > mental> > > retardation, have distinct facial and other physical > > characteristics and a> > > higher risk of some diseases.> > > > > > But not cancer, said Dr. Judah Folkman, a cancer expert at > > Children's> > > Hospital and Harvard Medical School in Boston. Ets2, which is > > found on> > > chromosome 21, may help explain why.> > > > > > "They are protected against cancer and also atherosclerosis and > > diabetic> > > retinopathy," Folkman, who was not associated with the > research, > > said in a> > > telephone interview.> > > > > > Diabetic retinopathy can cause blindness in people with > diabetes > > and, like> > > atherosclerosis, is associated with blood vessel function.> > > > > > STARVING TUMORS> > > > > > Folkman discovered a protein called endostatin that kick-> started a > > field of> > > cancer drugs called angiogenesis inhibitors. They starve a > tumour > > by> > > stopping it from creating blood vessels to nourish itself.> > > > > > The basic biological mechanism, which affects blood vessel > > function and> > > growth, may also underlie other so-called vascular diseases > such as> > > atherosclerosis, Folkman said.> > > > > > Folkman and other researchers believe people with Down's > produce > > extra> > > endostatin naturally, but also that other genes play an > important > > role. Ets2> > > appears to be one of them.> > > > > > "It is turning out to be very important because it gives a > strong > > clinical> > > clue that suggests some humans may be protected against > cancer," > > Folkman> > > said.> > > > > > "Down syndrome is always considered a tragedy for families. But > on > > the other> > > hand, they bring this huge clinical clue," Folkman said. The > genes > > that> > > protect against cancer appear to be separate from the genes > known > > to cause> > > mental retardation, he added.> > > > > > "In medical school in 1953 we were taught -- 'oh, by the way, > Down > > syndrome> > > individuals are protected against cancer'. Everybody asked why > and > > they> > > said, 'We think it is because they don't live long enough (to > > develop it),'"> > > Folkman said.> > > > > > But now Down's patients live into their 70s and they still > develop > > cancer at> > > a lower rate, he said.> > > > > > Dr. Threadgill of the University of North Carolina agreed > > that Ets2> > > might be used as the basis of a drug, but said far more > research > > is needed> > > because the protein also appears to help cancer spread, or > > metastasize, when> > > it does develop.> > > > > > "So therapeutic use of potential drugs with Ets2-like activity > to > > reduce> > > tumour incidence may have limited value, because a side effect > of > > such drugs> > > could be increased efficiency of metastasis," Threadgill wrote > in a> > > commentary. (Editing by Alan Elsner)> > > > > > http://uk.reuters.com/article/topNews/idUKN0264850120080102?> sp=true> > >> > > > > > > > > > > > > > ----------------------------------------------------------> ----------> > > > > > No virus found in this incoming message.> > Checked by AVG Free Edition. > > Version: 7.5.516 / Virus Database: 269.17.13/1208 - Release Date: > 1/3/2008 3:52 PM> >> > > > > > > ---------------------------------------------------------------------> > > No virus found in this incoming message.> Checked by AVG Free Edition. > Version: 7.5.516 / Virus Database: 269.17.13/1209 - Release Date: 1/4/2008 12:05 PM>

No virus found in this incoming message.Checked by AVG Free Edition. Version: 7.5.516 / Virus Database: 269.17.13/1210 - Release Date: 1/5/2008 11:46 AM