Drinking OJ Keeps Some Drugs From Working Properly

[Guest guest]

Drinking orange juice can make common prescription drugs almost 'useless'

By Fiona Macrae

Last updated at 4:16 PM on 19th August 2008 Daily Mail

Warning: Orange juice can stop prescription drugs from working properly

Drinking orange juice dramatically cuts the effectiveness of heart, blood

pressure and cancer drugs, research shows.

Apple and grapefruit juices also wipe out the effects of some antibiotics and

hay fever pills.

It is thought the breakfast juices stop the drugs from entering the

bloodstream and getting to work in the body - potentially rendering them

useless.

The researchers said the potential effects were so serious, that if in doubt,

people should swap their fruit juices for water when on medication.

Researcher said: 'This is just the tip of the iceberg. I'm sure

we'll find more and more drugs that are affected this way.'

Twenty years ago, Professor showed that grapefruit juice dangerously

magnifies the effect of the blood pressure drug felodipine - a finding that led

to warnings that the drink should be avoided by those on some medicines.

The latest study shows fruit juices can also cut the power of medicines -

potentially stopping them from doing any good.

Professor , of the University of Western Ontario in Canada, said: 'The

concern is loss of benefit of medications essential for the treatment of

serious medications.'

Drugs so far shown to be weakened by grapefruit, orange and apple juices

include the blood pressure-lowering beta blockers atenolol, celiprolol, and

talinolol and the hay fever treatment fexofenadine.

The popular antibiotic ciprofloxacin is also affected, as are the cancer drug

etoposide and a drug given to prevent transplanted organs being rejected.

But many other drugs are also likely to be affected, an American Chemical

Society conference has heard.

The researcher, a professor of pharmacology, advised patients to speak to

their doctor or pharmacist before taking fruit juice with their medicines.

Most medications should be taken with water, he said.

Professor made the link after asking a group of volunteers to take the

hay fever drug fexofenadine at the same time as either a glass of water or a

glass of grapefruit juice.

Taking the drug with the juice cut its absorption into the bloodstream by

half.

Experiments showed that naringin, the chemical behind the grapefruit's bitter

taste, blocked the drug from moving from the small intestine into the

bloodstream.

The researchers have pinpointed a naringin-like compound in orange juice and

are looking for a similar one in apples.

A different mechanism is at play with the drugs whose levels are boosted by

grapefruit juice. There, the juice inactivates a liver enzyme that breaks down

drugs, turning normal doses into potential overdoses.

The study is far from the first to link supposedly healthy juices with

dangers.

Last month, research from the respected Harvard Medical School in the US,

showed that just one glass of orange juice a day can significantly increase the

risk of the form of diabetes linked to poor diet and obesity.

Eating whole pieces of fruit however, cuts the likelihood of developing the

disease which affects some 2.5 million Britons.

It is thought the lack of fibre in juices may cause dangerous spikes in blood

sugar levels.

Drinking fruit juice can cut the benefits of some prescription drugs,

scientists have warned.

A range of common treatments, such as beta blockers, were only half as

effective when taken with some fruit juices.

A chemical found in grapefruit, apple and orange juice can wipe out the

beneficial effects of some drugs, it was found.

In a study, volunteers were given fexofenadine, a drug used for allergies,

with either grapefruit juice, water with naringin (a substance in grapefruit

juice that gives it a bitter taste), or plain water.

'When fexofenadine was taken with grapefruit juice, only half of the drug was

absorbed compared to taking the drug with water alone,' said Prof

of the University of Western Ontario.

**************

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deal here.

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[Guest guest]

Another good reason not to take drugs.

>

>

> Drinking orange juice can make common prescription drugs almost 'useless'

>

> By Fiona Macrae

> Last updated at 4:16 PM on 19th August 2008 Daily Mail

>

>

> Warning: Orange juice can stop prescription drugs from working properly

> Drinking orange juice dramatically cuts the effectiveness of heart, blood

> pressure and cancer drugs, research shows.

>

>

> Apple and grapefruit juices also wipe out the effects of some antibiotics and

> hay fever pills.

>

>

> It is thought the breakfast juices stop the drugs from entering the

> bloodstream and getting to work in the body - potentially rendering them

useless.

>

>

> The researchers said the potential effects were so serious, that if in doubt,

> people should swap their fruit juices for water when on medication.

>

>

> Researcher said: 'This is just the tip of the iceberg. I'm sure

> we'll find more and more drugs that are affected this way.'

>

>

> Twenty years ago, Professor showed that grapefruit juice dangerously

> magnifies the effect of the blood pressure drug felodipine - a finding that

led

> to warnings that the drink should be avoided by those on some medicines.

>

> The latest study shows fruit juices can also cut the power of medicines -

> potentially stopping them from doing any good.

>

>

> Professor , of the University of Western Ontario in Canada, said: 'The

> concern is loss of benefit of medications essential for the treatment of

> serious medications.'

>

>

> Drugs so far shown to be weakened by grapefruit, orange and apple juices

> include the blood pressure-lowering beta blockers atenolol, celiprolol, and

> talinolol and the hay fever treatment fexofenadine.

>

>

> The popular antibiotic ciprofloxacin is also affected, as are the cancer drug

> etoposide and a drug given to prevent transplanted organs being rejected.

>

>

> But many other drugs are also likely to be affected, an American Chemical

> Society conference has heard.

>

>

> The researcher, a professor of pharmacology, advised patients to speak to

> their doctor or pharmacist before taking fruit juice with their medicines.

>

>

> Most medications should be taken with water, he said.

>

>

> Professor made the link after asking a group of volunteers to take the

> hay fever drug fexofenadine at the same time as either a glass of water or a

> glass of grapefruit juice.

>

>

> Taking the drug with the juice cut its absorption into the bloodstream by

> half.

>

>

> Experiments showed that naringin, the chemical behind the grapefruit's bitter

> taste, blocked the drug from moving from the small intestine into the

> bloodstream.

>

>

> The researchers have pinpointed a naringin-like compound in orange juice and

> are looking for a similar one in apples.

>

>

> A different mechanism is at play with the drugs whose levels are boosted by

> grapefruit juice. There, the juice inactivates a liver enzyme that breaks

down

> drugs, turning normal doses into potential overdoses.

>

>

> The study is far from the first to link supposedly healthy juices with

> dangers.

>

>

> Last month, research from the respected Harvard Medical School in the US,

> showed that just one glass of orange juice a day can significantly increase

the

> risk of the form of diabetes linked to poor diet and obesity.

>

>

> Eating whole pieces of fruit however, cuts the likelihood of developing the

> disease which affects some 2.5 million Britons.

>

>

> It is thought the lack of fibre in juices may cause dangerous spikes in blood

> sugar levels.

>

>

> Drinking fruit juice can cut the benefits of some prescription drugs,

> scientists have warned.

>

> A range of common treatments, such as beta blockers, were only half as

> effective when taken with some fruit juices.

>

> A chemical found in grapefruit, apple and orange juice can wipe out the

> beneficial effects of some drugs, it was found.

>

> In a study, volunteers were given fexofenadine, a drug used for allergies,

> with either grapefruit juice, water with naringin (a substance in grapefruit

> juice that gives it a bitter taste), or plain water.

>

> 'When fexofenadine was taken with grapefruit juice, only half of the drug was

> absorbed compared to taking the drug with water alone,' said Prof

> of the University of Western Ontario.

>

>

[Guest guest]

Unless you're on a JUICE FAST (as I am this week)

> >

> >

> > Drinking orange juice can make common prescription drugs almost 'useless'

> >

> > By Fiona Macrae

> > Last updated at 4:16 PM on 19th August 2008 Daily Mail

> >

> >

> > Warning: Orange juice can stop prescription drugs from working properly

> > Drinking orange juice dramatically cuts the effectiveness of heart, blood

> > pressure and cancer drugs, research shows.

> >

> >

> > Apple and grapefruit juices also wipe out the effects of some antibiotics

and

> > hay fever pills.

> >

> >

> > It is thought the breakfast juices stop the drugs from entering the

> > bloodstream and getting to work in the body - potentially rendering them

useless.

> >

> >

> > The researchers said the potential effects were so serious, that if in

doubt,

> > people should swap their fruit juices for water when on medication.

> >

> >

> > Researcher said: 'This is just the tip of the iceberg. I'm

sure

> > we'll find more and more drugs that are affected this way.'

> >

> >

> > Twenty years ago, Professor showed that grapefruit juice

dangerously

> > magnifies the effect of the blood pressure drug felodipine - a finding

that led

> > to warnings that the drink should be avoided by those on some medicines.

> >

> > The latest study shows fruit juices can also cut the power of medicines -

> > potentially stopping them from doing any good.

> >

> >

> > Professor , of the University of Western Ontario in Canada, said:

'The

> > concern is loss of benefit of medications essential for the treatment of

> > serious medications.'

> >

> >

> > Drugs so far shown to be weakened by grapefruit, orange and apple juices

> > include the blood pressure-lowering beta blockers atenolol, celiprolol,

and

> > talinolol and the hay fever treatment fexofenadine.

> >

> >

> > The popular antibiotic ciprofloxacin is also affected, as are the cancer

drug

> > etoposide and a drug given to prevent transplanted organs being rejected.

> >

> >

> > But many other drugs are also likely to be affected, an American Chemical

> > Society conference has heard.

> >

> >

> > The researcher, a professor of pharmacology, advised patients to speak to

> > their doctor or pharmacist before taking fruit juice with their medicines.

> >

> >

> > Most medications should be taken with water, he said.

> >

> >

> > Professor made the link after asking a group of volunteers to take

the

> > hay fever drug fexofenadine at the same time as either a glass of water or

a

> > glass of grapefruit juice.

> >

> >

> > Taking the drug with the juice cut its absorption into the bloodstream by

> > half.

> >

> >

> > Experiments showed that naringin, the chemical behind the grapefruit's

bitter

> > taste, blocked the drug from moving from the small intestine into the

> > bloodstream.

> >

> >

> > The researchers have pinpointed a naringin-like compound in orange juice

and

> > are looking for a similar one in apples.

> >

> >

> > A different mechanism is at play with the drugs whose levels are boosted

by

> > grapefruit juice. There, the juice inactivates a liver enzyme that breaks

down

> > drugs, turning normal doses into potential overdoses.

> >

> >

> > The study is far from the first to link supposedly healthy juices with

> > dangers.

> >

> >

> > Last month, research from the respected Harvard Medical School in the US,

> > showed that just one glass of orange juice a day can significantly

increase the

> > risk of the form of diabetes linked to poor diet and obesity.

> >

> >

> > Eating whole pieces of fruit however, cuts the likelihood of developing

the

> > disease which affects some 2.5 million Britons.

> >

> >

> > It is thought the lack of fibre in juices may cause dangerous spikes in

blood

> > sugar levels.

> >

> >

> > Drinking fruit juice can cut the benefits of some prescription drugs,

> > scientists have warned.

> >

> > A range of common treatments, such as beta blockers, were only half as

> > effective when taken with some fruit juices.

> >

> > A chemical found in grapefruit, apple and orange juice can wipe out the

> > beneficial effects of some drugs, it was found.

> >

> > In a study, volunteers were given fexofenadine, a drug used for allergies,

> > with either grapefruit juice, water with naringin (a substance in

grapefruit

> > juice that gives it a bitter taste), or plain water.

> >

> > 'When fexofenadine was taken with grapefruit juice, only half of the drug

was

> > absorbed compared to taking the drug with water alone,' said Prof

> > of the University of Western Ontario.

> >

>