requested interpretation for Dr. Sally Burbank, part 1 of 2

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part one of two, cfids panel 3, nancy's interpretation of her tests,

not vojdani's....4-20-99 Interpretation of Immunosciences Tests

>>

>>Blood Tests for G. McFadden, Blood

>>Drawn on 1/19/99, for patient # 348-44-0030

>>

>>Referring Physician, Sally Burbank, M.D.

>>2021 Church Street, Suite 608; Nashville TN 37203

>>In order to adequately interpret the tests, one must know

>>the patient history, which is summarized below the abridged

>>summary of tests. This includes mycoplasma and chlamydia,

>>both intracellular bacteria, evident by symptom and lab test.

>>

>>=============================

>>Abridged summary of tests

>>=============================

>>

>>IgG Subclass Test; C3, C4 Complement; T and B Cell Function

>>(Lymphocyte Transformation) were normal. Quantitative

>>immunoglobulins and candida testing were normal. Antibodies

>>and rheumatoid factor were normal. CFS panel-wb was normal.

>>

>>The immune complex assay was on the border of normal for 2: IgG and

>>IgM, and abnormally high for IgA (13, with a reference range of 0-10).

>>

>>Most of the viral screen was within normal range except for:

>> (test) (results) (reference) (units)

>>IgG Epstein Barr Virus 1400 <100 IU/ML

>>IgM HHV-6 (Herpes Type-6) 25 0-20

>>IgG Varicella-Zoster 330 0-10 AcU/ML

>>

>> What other tests are there to clarify what abnormal titres

>> mean? Do the results indicate possible active infections?

>>

>>Some of the LYMPHOCYTE SUB-POPULATION tests were abnormal, including:

>> (test) (results) (reference) (units)

>>% SUPPRESSOR CELL (T8) 15.0 20-37%

>>TOTAL CD8+, CD11B+ CELLS 41.0 48-518 mm3

>>% OF CD8+, CD11B+ CELLS 2.0 5-12%

>>T-HELPER/T-SUPPRESSOR 3.3 1-2.5

>>TOTAL B CELL 410 48-648 mm3

>>% B CELL (B1, CD20) 20.0 5-15%

>>

>>The above lymphocyte tests relate to data below:

>>===============================

>>The LYMPHOKINE AND CYTOKINE TESTS seem to imply a th2 bias.

>>Low levels of th1 cytokines and NO IFN-gamma raise a red flag

>>when compared to normal levels of th2 cytokines.

>>==============================================================

>>(test) (results) (reference) (units)

>>INTERFERON-ALPHA-SERUM 1.0 0-4 Pg/ml

>>

>>INTERFERON GAMMA 0.0 0-5 Pg/ml

>>

>>IL-1 ALPHA 1.00 0-5 Pg/m1

>>

>>IL-1 BETA 1.00 0-5 Pg/m1

>>

>>IL-2 LEVEL 2.3 0-20 Pg/ml

>>

>>IL-2 RECEPTOR 76.0 25-120 PM

>>

>>TGF-BETA 1 1.0 0-20 Pg/m1

>>

>>TNF-ALPHA 5.0 0-39 Pg/ml

>>

>>IL-4 LEVEL 28. 0-50 Pg/ml

>>

>>IL-6 15.0 0-50 Pg/ml

>>

>>IL-10 10.0 2-24 Pg/ml

>>

>>==========================

>>(related to immune function)

>>

>>T-HELPER/T-SUPPRESSOR 3.3 1-2.5

>>(ratio of cd4 to cd8)

>>

>>NK CELL ACTIVITY 22.00 20-50 LUs

>>(only 15% of the " normal "

>>population have a score

>>below 30 lytic units.)

>>22 LUs, while normal, is not

>>optimal or even close to it.

>>=========================================

>>

>> McFadden timeline concerning mycoplasma

>>and chlamydia and her cfids history.

>>

>>12-17-86 Pregnancy starts (planned).

>>

>>1-10-87 Bad infection, severe headache, sore throat,

>>pain, and fever after family wedding and high stress

>>weekend. (3 weeks pregnant at beginning of cfids)

>>

>>1-87 to 5-87 continued teaching 6th grade - with

>>sickest " green snot " class. New school building sprayed

>>at least once a month. Exhausted, headaches, severe pain.

>>

>>1-87 to 9-87 Tested positive for mycoplasma pneumoniae

>>2+ times with complement fixation test during pregnancy.

>>Antibiotics given, very ill. born healthy with

>>no birth defects or obvious problems.

>>

>>9-87 to 9-90 Tested positive several more times for

>>mycoplasma with comp. fix. test. On antibiotics over

>>50% of every year with obviously purulent mucous.

>>

>>12-90 First visit with Dr. Burbank, who found bad

>>candida, bacterial problems.

>>

>>9-89 to 9-92 Attempted to resolve with parttime antibiotics,

>>nystatin, diet, avoidance of toxins, endoscopic lasering,

>>nasal lavages. This helped to improve the worst problems.

>>

>>9-92 Tonsils removed. (lowered the level of pain)

>>Continued infections after.

>>

>>9-92 to 6-95 Ear tubes helped. Some green mucous and

>>cfids symptoms. Occasional antibiotics. Pain relief

>>and antihistamines key to semi-normal functioning.

>>

>>6-95 to 12-95 Relapsed badly after a car accident,

>>dad dying and handling mother's move from Chicago.

>>The old 1987 problems all flared - big relapse.

>>

>>1-96 to 10-96 I was deathly ill and often in bad pain

>>and very fatigued. Almost non-functional some days.

>>

>>10-96 Dr. Burbank offers to test for chlamydia

>>pneumoniae in cooperation with Vanderbilt researcher

>>Dr. Stratton. Positive PCR and immunoglobin

>>test from Mayo Clinic. Antibiotics started.

>>

>>10-96 to 10-97 Relief given for the severe sore

>>throats and gradually many other symptoms faded.

>>

>>late 97 - Attempted going off antibiotics - relapsed

>>within weeks. We discovered why Stratton said long

>>term ABX require many years! Stopping early = relapse.

>>

>>4-98 Flew to California to speak at Pesticide Reform conference,

>>Felt OK before trip. After--> 3 weeks in bed recovering from

>>killer sore throat, fatigue, lymph node swelling. (We think

>>airplane air may have aggravated chlamydia.)

>>

>>2-99 One day trip to Atlanta (brain/endocrine disruptor conf.),

>>caught a bad infection, and was in bed for 2 1/2 weeks with a

>>bronchitis and sinus infection. Person who passed the infection

>>was better after 2 days of antibiotics, missed no work. My

>>response and recovery time was terrible compared to his.

>>

>> Are there any plausible explanations evident on the

>> tests for how severely and quickly gets run down?

>>

>> Does it make sense to do endocrine testing since

>> you indicated that DHEA might help the imbalance

>> in the helper/suppressor ratio? What are

>> implications for taking estrogen (HRT)?

>>

>>1-87 to 4-99 - When around pesticides, sick buildings or

>>other toxins, glands swell, throat is sore. Overexertion

>>has same effect. Dr. Quisling has observed with

>>endoscope the throat, ear, sinus inflammation. Occasional

>>joint pain, severe fatigue, and diarrhea from toxins.

>>

>> According to AIDS data - activated CD4 dominance over

>> CD8 can cause lymph swelling, which might mean the

>> same thing could happen with cfids. Do the symptoms

>> relate to my abnormal helper/suppressor ratio?

>>

>>9-89 to 4-99 no mycoplasma pneumoniae tests run for many years,

>>but symptoms are similar to chlamydia pneu. which is positive

>>and apparently, through clinical observation, still with me.

>>

>> Is it possible to carry both organisms? Could

>> mycoplasma have started the immune dysfunction

>> still apparent after 2 FULL years of antibiotics?

>>

>> end of part 1 - part 2 continues next