Re: Mycoplasma & co-infections & blisters>Susy

[Guest guest]

In a message dated 8/13/99 9:08:48 PM Eastern Daylight Time,

jrobinso@... writes:

>

> THis sound like FIXED DRUG ERUPTIONS - which I get to macrolides and doxy,

> which are still a mystery, and which sometimes can be dangerous or at least

> very debilitating.

I will have to read this one julian, very carefully, Thank You...

Mine were on the fatty part of palms and arches of the feet, while on the

6week doxy capsules, Tiny water itchy blisters, but I have had them before

and after doxy in those yrs. usually in the summers, but never to the extent

of that time, usally just an annoyance, several blisters at a time, You would

need a magifying glass to see, but you could feel them. , I had always

chalked up to heat or stress,

I will look this up and also ask my present Dr. about it

At the time no one was surprised, the researcher just wanted to know how

severe was it , made notes....and my GP said come to the ER for sauve to help

the itch.

Since then I have also learned some fillers in the capules of doxy, people

could be allergic too...

Who knows but will read your info and look up...

again Thank You

Susy......still riding the wave

[Guest guest]

Hi Susy - Do you have any details of drugs etc that interfere with abx?

>I have heard thru the gossip lines, many drugs now interfer with abx use and

>cancels them out, not just food sources, I beleive this is why in some part

------------

>cfs/ms/postlyme,gwi researcher, we tried a 6 week doxy 3 1/2 yrs ago , so i

>was fortunate to know doxy did help, that herx was headaches that were awful

>and tiny water blistering of the palms and arches of my feet, itched beyond

>expalining, but then skin hardened & peeled off like a bad sunburn and had

>such soft perrty feet an d hands for awhile,

THis sound like FIXED DRUG ERUPTIONS - which I get to macrolides and doxy,

which are still a mystery, and which sometimes can be dangerous or at least

very debilitating. There is a lot of literature on the web about this, my

doctor knows nothing about it, so as usual we have to educate them. I attach a

piece on this, but if you are interested there is much more on the net. JR

------------

CUTANEOUS DRUG ERUPTIONS

Dr. L.Y. CHONG

CHAPTER 23

Cutaneous drug eruptions may be defined as adverse cutaneous lesions as a

consequence of administration of drugs.

The pathogenesis of drug eruptions may arise as a result of immunological or

non-immunological reaction. Some of these reactions are predictable

(dose-related) while some are unpredictable (idiosyncratic). Those with an

immunological basis may due to different types of hypersensitivity reactions,

for instance, allergic type of urticaria may be the result of Type I reaction

(IgE-mediated) or Type III reaction (complement dependent immune-complex

mediated). Nevertheless, the exact mechanisms of most drug eruptions, including

fixed drug eruptions, are unknown.

Clinically drug eruptions have a wide range of different morphological

presentations. (Table 1) They can be generalized or fixed eruptions and their

severity varies from minor to fatal skin reactions. Unfortunately, apart from

fixed drug eruption, there is neither pathognomonic clinical feature nor

diagnostic investigation in drug eruption. In practice, it is often difficult

to identify the culprit with certainty, especially when the patient is taking

multiple drugs simultaneously. Diagnosis is mainly based on clinical grounds in

which the history plays the most essential part. In the history, the temporal

relationship between the taking of drug and the onset of skin eruption is most

important. Experience and statistical knowledge about the suspected drugs are

also useful as certain drugs (for examples, ampicillin or cotrimoxazole) are

more likely to cause drug eruptions, especially in certain diseases (for

examples, AIDS or infectious mononucleosis).

In the history, the following information should be carefully asked:

A detail drug history including the names and dosage of the drugs taken (Drugs

should include those prescribed by doctors and any herbal or homeopathic

medicines)

The temporal relationship between the intake of drugs and the onset of skin

lesions (Allergic drug reactions usually develop within 1 to 2 weeks of

initiation of treatment)

Any previous history of drug allergy, or similar skin lesions after taking

similar drugs

Any improvement of skin lesions after the suspected drug is withdrawn (The skin

eruption is unlikely to be drug-induced if it fails to improve after withdrawal

or if it improves even without stopping the drug. However, sometimes it may

takes weeks for drug eruption to resolve even when the drug is stopped.)

Up to the present moment, there is still no reliable and practical

investigation for confirmation of drug eruption. Rechallange test is dangerous

and should not be carried out in usual circumstances. Perhaps the only

situations for rechallange test are those with fixed drug eruptions or those

with life-threatening conditions in which that particular drug is essential.

Skin test has little practical value as it may cause fatal systemic reaction

and false positive reaction is common. Other tests such as radioallergosorbent

tests (RAST) for drug-specific IgE antibody (penicillin, insulin), histamine

release test, leucocyte and macrophage migration inhibition tests, lymphocyte

toxicity assay, basophil degranulation test, passive haemagglutination test and

lymphocyte transformation test are mainly for research purposes.

n

Tel/Fax +61-2-6239 6226

Canberra, Australia

[Guest guest]

Susy - I guess your blisters can not be FDE's then if they occur when not

taking drugs - sorry I misunderstood.

n

At 13:46 14/08/99 , you wrote:

>From: SUSYDOG@...

>

>In a message dated 8/13/99 9:08:48 PM Eastern Daylight Time,

>jrobinso@... writes:

>

>>

>> THis sound like FIXED DRUG ERUPTIONS - which I get to macrolides and doxy,

>> which are still a mystery, and which sometimes can be dangerous or at least

>> very debilitating.

>I will have to read this one julian, very carefully, Thank You...

>Mine were on the fatty part of palms and arches of the feet, while on the

>6week doxy capsules, Tiny water itchy blisters, but I have had them before

>and after doxy in those yrs. usually in the summers, but never to the extent

>of that time, usally just an annoyance, several blisters at a time, You would

>need a magifying glass to see, but you could feel them. , I had always

>chalked up to heat or stress,

>I will look this up and also ask my present Dr. about it

>At the time no one was surprised, the researcher just wanted to know how

>severe was it , made notes....and my GP said come to the ER for sauve to help

>the itch.

>Since then I have also learned some fillers in the capules of doxy, people

>could be allergic too...

>Who knows but will read your info and look up...

>again Thank You

>Susy......still riding the wave

>

>---------------------------