Re: Reason for slow progression? -Notan-

[Guest guest]

Hi Notan,

As promised I asked Dr. Gockel more info on this subject. Yesterday evening she

replied that she had been very busy last week due to a congress she co-organised

and had to attend of course. This week she's in the operating room a lot and

therefore hasn't got enough time to give you the best possible answer untill

coming weekend, this as it is complicated stuff that she really needs to look

into.

I'll let you know as soon as I know more.

Isabella

________________________________

From: Isabella Arnold <arnoldisabella@...>

achalasia

Sent: Wednesday, December 3, 2008 8:37:31 AM

Subject: Re: Reason for slow progression?

Well, Notan, I guess that's a question for Dr. Gockel... I'll forward this

message to her and let you know the answer I receive.

Love,

Isabella

____________ _________ _________ __

From: notan ostrich <notan_ostrich@ cox.net>

achalasia@grou ps.com

Sent: Wednesday, December 3, 2008 2:25:03 AM

Subject: Reason for slow progression?

I found the results of my blood test. I have low IgG. (IgG is the main

type of antibodies.) Not low enough to be causing me problems with

infections but below the normal range, aprx. 500 or 600 if I heard

right. So, once again I have another odd condition but at least it

doesn't seem to be causing me any problems.

Anti-neural antibodies have been found in achalasia patients. However,

the nature of these antibodies is that they don't seem to be specific

against the neurons that are effected in achalasia and so it is though

that they may not represent the cause of achalasia. However, perhaps

they are part of a group of factors stressing those neurons, such as, a

virus hiding in them, inflammation from allergies and even the NOS the

neurons produce. If so, then perhaps my low IgG is why my achalasia took

so many years to progress.

I wonder if Isabella's researcher would have any thoughts on this?

Antineuronal antibodies in idiopathic achalasia and gastro-oesophageal

reflux disease (2003)

http://www.pubmedce ntral.nih. gov/articlerende r.fcgi?artid= 1773656

" In general, the antibodies in achalasia serum were specific to enteric

nerves, but were not specific to subpopulations of enteric neurones.

These results bring into question the theory that antineuronal

antibodies are a principal aetiological factor in the development of

idiopathic achalasia. If this were the case, we would have expected

specificity to nitrergic neurones located in the oesophagus and LOS, and

we would not expect to detect comparable immunostaining with serum from

GORD patients. "

notan