Re: [scilyme] Chemokines and response to antibiotics

[Guest guest]

W. wrote:

>

> From: " W. " <wj_martin@...>

>

> I recently posted two messages to cpar news group in response to discussion

> on why some CFS patients respond to antibiotics. I am pleased to copy my

> comments to the scilyme list.

> Kind regards, W. .

>

> Dear cpar members,

> Lucy Dechene recently posted a comment regarding work from CCID on

> the role of antibiotics in suppressing cytokine activation of stealth

> viruses. In a paper to appear in Experimental and Molecular Pathology, I

> been able to show that the prototype stealth virus has five copies of a

> critical viral gene that codes a chemokine receptor. The finding implies a

> role for chemokines in the pathogenicity of at least some stealth-adapted

> viruses. It may also help explain the apparent therapeutic benefit achieved

> in certain stealth virus infected patients treated with agents that down

> regulate chemokine production. These compounds include various antibiotics,

> for example Biaxin (Matsuoka et al Clin Exp Immunol 104:501-8,1996); a broad

> range of agents referred to as DMARD (disease modifying anti-rheumatic

> drugs) used by rheumatologists; certain neuropsychiatric medications and a

> variety of dietary supplements.

>

> The question remains as to which combinations of therapies will work

> best in individual patients. The stealth virus culture method is proving

> useful as a semi-quantitative assay to serially monitor the level of stealth

> virus activity. I would appreciate clinical input as to how to structure a

> graduated protocol of agents to be used in stealth virus infected adults and

> children.

> Regards, W.

>

> Dear cpar members,

>

> I was pleased to see some discussion regarding cytokine/ chemokines

> and antibiotic use. The following comments may be useful.

>

> 1. Although cytokines(which include chemokines) do play a role in immune

> regulation, they have many additional functions. The chemokine receptors

> present in the prototype stealth virus are more closely related to chemokine

> receptors that mediate neuron-glial cell interactions within the brain; than

> to those present on lymphocytes. Stealth virus induced disruption of

> chemokine:receptor interactions between brain cells could contribute to

> cognitive, mood and sleep disorders. Certainly this is more likely than an

> indirect effect resulting from immune dysregulation.

>

> 2. The interpretation of a positive test for a bacterial infection needs to

> be reexamined in light of our finding that bacterial sequences can be

> incorporated within stealth viruses. ( " Bacteria Related Sequences in a

> Simian Cytomegalovirus-Derived Stealth Virus Culture " Exp Mol Path

> 1999;66:8-14). The term " viteria " is being used for viruses that contain

> bacterial sequences. The variety and types of sequences incorporated into

> the prototype stealth virus are truly impressive and include Borrelia (the

> bacterium associated with classic Lyme disease); mycoplasma; rickettsiae;

> brucella; etc. Even some sequences of fungal origin have been found. It is

> just as likely that these incorporated sequences, rather than whole living

> bacteria, account for the positive assays used to diagnose the bacterial

> infections being ascribed to patients with chronic fatiguing llnesses.

> Furthermore, a reduction in such assays, for example following antibiotics,

> could simply reflect a reduction in stealth virus level, rather than prove

> that a widespread bacterial infection existed.

>

> 3. This opinion is supported by the reversion from strong positive to only

> weak positive stealth virus cultures in treated patients diagnosed as having

> chronic Lyme disease, CFS, Gulf war syndrome, etc. Electron microscopy of

> the cultures and of tissue biopsies obtained from some patients shows

> atypical viruses and not bacteria. A brief article entitled " Are stealth

> virus infected patients being misdiagnosed as having Lyme disease " is

> scheduled to appear soon in a newsletter and will be uploaded on

> www.ccid.org web page

>

> 4. Antibiotics should probably not be the first line of treatment to try to

> suppress chemokine mediated pathways of viral activation. There are many

> safer alternatives. Antibiotics do have a role if viteria infected bacteria

> can be identified, or if simpler methods prove unsuccessful. Anti-viral

> agents also need to be considered.

>

> Additional information and copies or earlier papers are on the web site.

> Kind regards, W. , M.D., Ph.D.

>

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