Antiphospholipid Antibodies

[Guest guest]

As some of you know, I got the hypercoag test from HEMEX and turned

out to be extremely hypercoaguable. I also got the hereditary factors

test that showed that I have 3 different genetic defects that affect

clotting

(unfortunately all three inhibit fibrinolysis).

Based on this I decided to get the antiphospholipid antibody test.

Turned out really positive. Normals are 0-20 and mine are 60.

For those that are interested info on antiphospholipid antibodies

(an autoimmune problem) can be found at:

http://members.aol.com/AMAmail/Anti.html

<http://members.aol.com/AMAmail/Anti.html>

Interestingly - I HAVE had an anti cardiolipin antibody test

AND an ANA (antinuclear antibody) test and they BOTH

were negative (both of these are phospholipids).

Berg said that most of the hypercoag people test positive

for antiphospholipids. I told him, " but I've already tested

negative for ANA and cardiolipin antibodies " . But he told

me that their test is a little different and tests for the beta-2

glycoprotein-I antibody which can be very positive in people

negative for anti-cardiolipin and ANA (however very few

doctors know about this)

Good article (including b-2 glycoprotein-I):

Origin and pathogenesis of antiphospholipid antibodies:

http://www.epub.org.br/bjmbr/year1998/v31n6/3100c.htm

<http://www.epub.org.br/bjmbr/year1998/v31n6/3100c.htm>

Also of some interest is that it was my IgA anti b-2 glycoprotein-I

that was positive (not IgG or IgM) which indicates that there is

a mucosal infection.

Patti

--

[Guest guest]

Hi,

ANti-phospholipid anti-body was detected in me also as well as positive ANA

- up to 5000 titer at times! Normal is <1:40. ANA is only an indicator that

there is a problem and not specific enough, but it is used to dx lupus,

scleroderma and other autoimmune diseases. If anti-cardio lipid is positive

it is a good idea to be followed by CARDIO and RHEUM. What were the genetic

defects?

Take care,

Christie

--------------------------------------

>From: " Skari, M " <SkariPM@...>

>>As some of you know, I got the hypercoag test from HEMEX and turned

>out to be extremely hypercoaguable. I also got the hereditary factors

>test that showed that I have 3 different genetic defects that affect

>clotting

>(unfortunately all three inhibit fibrinolysis).

>

>Based on this I decided to get the antiphospholipid antibody test.

>Turned out really positive. Normals are 0-20 and mine are 60.

>

>For those that are interested info on antiphospholipid antibodies

>(an autoimmune problem) can be found at:

>

>http://members.aol.com/AMAmail/Anti.html

><http://members.aol.com/AMAmail/Anti.html>

>

>Interestingly - I HAVE had an anti cardiolipin antibody test

>AND an ANA (antinuclear antibody) test and they BOTH

>were negative (both of these are phospholipids).

>

>Berg said that most of the hypercoag people test positive

>for antiphospholipids. I told him, " but I've already tested

>negative for ANA and cardiolipin antibodies " . But he told

>me that their test is a little different and tests for the beta-2

>glycoprotein-I antibody which can be very positive in people

>negative for anti-cardiolipin and ANA (however very few

>doctors know about this)

>

>Good article (including b-2 glycoprotein-I):

>

>Origin and pathogenesis of antiphospholipid antibodies:

>

>http://www.epub.org.br/bjmbr/year1998/v31n6/3100c.htm

><http://www.epub.org.br/bjmbr/year1998/v31n6/3100c.htm>

>

>Also of some interest is that it was my IgA anti b-2 glycoprotein-I

>that was positive (not IgG or IgM) which indicates that there is

>a mucosal infection.

>

>Patti