Re: 2,3 DPG

[Guest guest]

Has anyone seen any news coming from the Canadian research on 2,3 DPG? As of

a year ago, I believe testing for it is not availabkle in the U.S. Anyone

have info to the contrary?

Jim

[Guest guest]

on 7/2/00 2:58 PM, jschm111@... at jschm111@... wrote:

> Has anyone seen any news coming from the Canadian research on 2,3 DPG? As of

> a year ago, I believe testing for it is not availabkle in the U.S. Anyone

> have info to the contrary?

It should be available, at least in the USA. When I was perusing one of the

Lippincott & Wilkins Primary Care Online texts, _Diagnostic Tests_, it

listed 2,3-DPG as an available test and even gave instructions on how to

give the test.

Hud

---

[Guest guest]

My last information.....about a year old....is that there is no

commercial test for determining

the amount of 2,3 DPG in your body. Further, testing for it at a

research kind of lab is very difficult.

Some of you may remember an article awhile back about a " TEEN's

DISCOVERY " , (she was from Canada, and the daughter of a prominent

doctor there.) Using an extremely small sample, she discovered a simple

way to test for 2,3 DPG levels. Unfortunately, when the test was

expanded to a larger sample, it did not work any more. As I understand

it, that was the end of her research project.

Does anyone know more about this?

Laurion

[Guest guest]

Hi, Bob.

The tissues are made up of cells, so they are really saying the same

thing.

I think there is a cart-and-horse issue here. I think it's agreed

that the cells are not using as much oxygen as normal. The question

is whether this is because they have an internal problem which

prevents them from carrying on their metabolism as rapidly as normal,

so that they don't call for as much oxygen as normal, or whether it's

because oxygen is not being transported to them as fast as they would

like to have it. In other words, " Where's the hold-up? "

I think it can be either way, depending on the particular subset of

PWCs. But whichever way it is, I don't think 2,3 DPG, now called 2,3

BPG, is the culprit.

There are tests that can determine which it is in a given case. I

think the first ones to do are the arterial blood gases test and the

venous blood gases test. By looking at the oxygen saturation in the

two, you can figure out what the situation is. If the person has low

cardiac output, as Dr. Cheney is now finding in most of his patients,

and this is dominating the oxygen delivery to the skeletal muscle

cells, then I would expect to see a normal oxygen saturation in the

arterial blood, but a lower than normal one in the venous blood.

Someone reported results like this on the list sometime back. That

would say that the muscle cells are drawing down the oxygen lower than

normal because not enough is being supplied. On the other hand, if

the arterial oxygen saturation is normal and the venous oxygen

saturation is higher than normal, that would say that the cells are

not taking as much oxygen as normal, and that would suggest an

internal problem in the cells, such as a partial blockade in the

oxidative metabolism. I think we had reports like that from one or

more people earlier on. So I think it can go either way, but I don't

think the problem is 2,3 BPG.

Rich

>

> I once heard Dr Cheney say that though we have plenty of oxygen in

the

> blood there was not enough in the cells. someone on another list

said

> that it was because of a lack of the above. I did a search and it

said

> that this metabolite is what moved oxygen from the cell to tissue.

this

> does not seem to be the same as moving it from blood to the cells.

>

> Anyone know for sure if a lack of 2,3 DPG is causing a problem in

CFS?

>

> Bob

>