Re: Dave and Laughing Gas

[Guest guest]

I use nitrous oxide at the dentist, because I'm sensitive to mouth

pain and get adrenalin rushes etc. with some procedures there. I

have a mouthful of crowns now. I may be sensitive to the gas because

I can't tolerate much, they have to turn it down from their usual

setting (whatever that is) and it takes very little to send me

floating out the window, but it has made an enormous difference in my

stress level there. For some of us, it becomes an interesting trade

off: adrenalin or nitrous.

I am interested in Dave's ideas (although hoping very much that it

doesn't apply to me because I love my vegies), and I'm willing to

give it a go for a couple of weeks and see what happens.

Laurie Lassesen

[Guest guest]

on 7/2/00 11:58 AM, Chute at mchute1@... wrote:

> I use to do Nitis Oxicide for fun and am guilty of " playing " with it

> for its mind altering properties. Is it possible that PWC may have a

> genetic predispostion to being sensitive to NO2? Could the dosage of

> NO2 be responsible for some form of damage in us?

>

> This is an open question: Is there anyone else (PWC) who has NO2 in their

> past?

Hi ,

You may be *guilty* of playing with NO2, but I did NO2 as well for fun and

I'm *innocent* of it! %^D [wah wah wah wah wah...].

The thing I'm wondering here, not being myself educated in chemistry, is

whether NO and NO2 even have similar pharmacological effects... I somehow

doubt it because NO2 has been shown to act as an NMDA antagonist (like

ketamine, dextromethorphan, Neurontin, lidocaine) and NMDA antagonists are

generally beneficial to PWC.

In fact, Cheney has remarked that there isn't a single drug which

antagonizes NMDA receptor that doesn't help CFIDS in some manner or form;

plus, NMDA antagonists have been shown to decrease NO activity in the

hypothalamus and other brain areas. IMO this loosely implies that NO2

should actually decrease NO activity, in the brain at least.

This is speculation on my part, to be sure.

Re: damage by NO2 - as with excessive use of any NMDA antagonists, there is

a risk of developing neurotoxicity. The form which the neurotoxicity takes

was coined " Olney's lesions " , after the guy called Olney discovered them.

It is unclear so far as to just how likely it is to develop these lesions

after NMDA antagonist use.

Hud

---

[Guest guest]

Hud,

Your science is out of my league but the assoication of usage and

your present condition is interesting.

You are at least one confirmed user who has symptoms.

Are there more?

Is there anyone who has not been exposed at all to the agent?

I think I'm hunting for statistic validation of the possiblity and

then seeking the science to verify it.

Speaking of statistics. Many times I've dreamed of a toxicological

survey seeking a number of possible toxicologial agents in PWC's past

but have never had the brain power or the time to implement it. My

very first onset about 10 years ago and coninsided with moving into

my wife's house with new furnature and carpet and new paint on the

walls. Chemical Exposeures by Ashford and details many illness

incidents from that combination. AND the symptomology is practically

the same as us.

>on 7/2/00 11:58 AM, Chute at mchute1@... wrote:

>

>> I use to do Nitis Oxicide for fun and am guilty of " playing " with it

>> for its mind altering properties. Is it possible that PWC may have a

>> genetic predispostion to being sensitive to NO2? Could the dosage of

>> NO2 be responsible for some form of damage in us?

>>

>> This is an open question: Is there anyone else (PWC) who has NO2 in their

>> past?

>

>Hi ,

>

>You may be *guilty* of playing with NO2, but I did NO2 as well for fun and

>I'm *innocent* of it! %^D [wah wah wah wah wah...].

>

>The thing I'm wondering here, not being myself educated in chemistry, is

>whether NO and NO2 even have similar pharmacological effects... I somehow

>doubt it because NO2 has been shown to act as an NMDA antagonist (like

>ketamine, dextromethorphan, Neurontin, lidocaine) and NMDA antagonists are

>generally beneficial to PWC.

>

>In fact, Cheney has remarked that there isn't a single drug which

>antagonizes NMDA receptor that doesn't help CFIDS in some manner or form;

>plus, NMDA antagonists have been shown to decrease NO activity in the

>hypothalamus and other brain areas. IMO this loosely implies that NO2

>should actually decrease NO activity, in the brain at least.

>

>This is speculation on my part, to be sure.

>

>Re: damage by NO2 - as with excessive use of any NMDA antagonists, there is

>a risk of developing neurotoxicity. The form which the neurotoxicity takes

>was coined " Olney's lesions " , after the guy called Olney discovered them.

>It is unclear so far as to just how likely it is to develop these lesions

>after NMDA antagonist use.

>

>Hud

>---

[Guest guest]

I think we are all different. Although I have used Nitrous at the

dentist, it's only been for about 5 years, and my condition goes back

about 18 years. I have felt a little ill from the nitrous if it is

at the normal settings (it doesn't take much) - so you could say I am

sensitive because it doesn't take much to affect me.

This illness is so complex - I'm grateful for all the work people are

doing for it, because I don't have enough active brain cells to

figure much out for myself. Ah, but a couple of weeks ago, I was

lamenting to a friend on the phone, saying that I used to be a lot

smarter and our teenager quipped " that's scary, you're smarter than

me now! " . I don't think it's true, but it was cute.

Laurie Lassesen