Cymbalta

April 19, 2007

I tried cymbalta.......it had an immediate beneficial effect on

pain/stiffness levels, but the side effets were horrible. This;

however is normal for me with SSRI's but even more pronounced with

cymbalta. I immediately felt calm and more energetic, dramatically

so. But by day 3 I was sleeping all the time, my libido was dead, I

couldn't tutor math for crap; something I pride myself on and how I

make my living. This on only 30mg/day. Needless to say I stopped.

I studied it though and for depression it is prob the best SSRI out

there now and esp if you have fibro.

April 20, 2007

Delve in this site for Mg re depression, cellular energy, pain and etc.

Malic acid form of Mg helps with energy. I get Mg chloride on ebay, cheaper

than from the other site mentioned.

Don't forget Mg's co-factor B6 and also the importance of fish oil for

omega-3 fatty acids in mood.

_http://george-eby-research.com/html/depression-anxiety.html_

(http://george-eby-research.com/html/depression-anxiety.html)

Hope this helps mjh

Posted by: " ph " _joey2276@... _ (mailto:joey2276@...?Subject=

Re:%20cymbalta) _joey2276 _ (joey2276)

Thu Apr 19, 2007 3:01 pm (PST)

I tried cymbalta....I tried cymbalta....<WBR>...it had an immediat

pain/stiffness levels, but the side effets were horrible. This;

however is normal for me with SSRI's but even more pronounced with

cymbalta. I immediately felt calm and more energetic, dramatically

so. But by day 3 I was sleeping all the time, my libido was dead, I

couldn't tutor math for crap; something I pride myself on and how I

make my living. This on only 30mg/day. Needless to say I stopped.

I studied it though and for depression it is prob the best SSRI out

there now and esp if you have fibro.

************************************** See what's free at http://www.aol.com.

May 8, 2007

I found this information at

http://www.cymbalta.com/depression/about/side_effects.jsp?reqNavId=3.5

From that page click on Prescribing Information and it will take you

to where this is located. Hope that it helps..

Hepatic Insufficiency — Patients with clinically evident hepatic

insufficiency have decreased duloxetine metabolism and elimination.

After a single 20-mg dose of Cymbalta, 6 cirrhotic patients with

moderate liver impairment (Child-Pugh Class had a mean plasma

duloxetine clearance about 15% that of age- and gender-matched

healthy subjects, with a 5-fold increase in mean exposure (AUC).

Although Cmax was similar to normals in the cirrhotic patients, the

half-life was about 3 times longer (see PRECAUTIONS). It is

recommended that duloxetine not be administered to patients with any

hepatic insufficiency

>

> I have been on cymbalta pre treatment and now during treatment. Now

I hear

> cymbalta is not good for my liver? I found cymbalta was better

than zoloft.

>

> why is cymbalta bad? (some folks take it for fybromyalgia, too)

> amy

>

> ************************************** See what's free at

http://www.aol.com.

>

May 8, 2007

I found this information at

http://www.cymbalta.com/depression/about/side_effects.jsp?reqNavId=3.5

From that page click on Prescribing Information and it will take you

to where this is located. Hope that it helps..

Hepatic Insufficiency — Patients with clinically evident hepatic

insufficiency have decreased duloxetine metabolism and elimination.

After a single 20-mg dose of Cymbalta, 6 cirrhotic patients with

moderate liver impairment (Child-Pugh Class had a mean plasma

duloxetine clearance about 15% that of age- and gender-matched

healthy subjects, with a 5-fold increase in mean exposure (AUC).

Although Cmax was similar to normals in the cirrhotic patients, the

half-life was about 3 times longer (see PRECAUTIONS). It is

recommended that duloxetine not be administered to patients with any

hepatic insufficiency

>

> I have been on cymbalta pre treatment and now during treatment. Now

I hear

> cymbalta is not good for my liver? I found cymbalta was better

than zoloft.

>

> why is cymbalta bad? (some folks take it for fybromyalgia, too)

> amy

>

> ************************************** See what's free at

http://www.aol.com.

>

May 8, 2007

Amy, Cymbalta has been shown to CAUSE liver failure in 'some' folks and now carries that BLACK BOX warning on it... but just as no med is perfect for everyone,, you may be able to use it safely.. but if it were me, I'd not use it because of the extra warnings they have posted on the box regarding cymbalta and liver issues... I take Lexapro and before that I took Celexa when I was on treatment,, they worked well for me.. I know many others who have tried zoloft and paxil and both of those were very hard to get off of after treatment,, and I have seen others start on paxil and shake like crazy for weeks,,, so you see, not everything works well for everyone.. I'd certainly sit down with your doc and discuss the Black Box Warning on Cymbalta and ask your doc if he knows about that and why he is giving it to you and perhaps there is a different ssri you can take at least while you are on tx.. Has he checked your liver functions tests frequently? I'd say

that if you are on this med and on treatment at the same time,, I'd want tests done either weekly or bi-weekly to make sure you catch any problem before it gets out of hand.. Our livers are the one thing that can regenerate thank goodness but who wants to damage it further... Here is a URL that you can go and read about Cymbalta ,, please scroll down the the Warning area and you can read for yourself,,, http://pi.lilly.com/us/cymbalta-pi.pdf I tried to copy and past just the pertinent info but it wouldnt let me copy it so you will have to go and read for yourself.. Ill post another article about cymbalta to follow this ,, jaxJurydoctor@... wrote: I have been on cymbalta pre treatment and now during treatment. Now I hear cymbalta is not good for my liver? I found cymbalta was better than zoloft. why is cymbalta bad? (some folks take it for fybromyalgia, too) amy See what's free at AOL.com. Jackie

May 8, 2007

Amy, Cymbalta has been shown to CAUSE liver failure in 'some' folks and now carries that BLACK BOX warning on it... but just as no med is perfect for everyone,, you may be able to use it safely.. but if it were me, I'd not use it because of the extra warnings they have posted on the box regarding cymbalta and liver issues... I take Lexapro and before that I took Celexa when I was on treatment,, they worked well for me.. I know many others who have tried zoloft and paxil and both of those were very hard to get off of after treatment,, and I have seen others start on paxil and shake like crazy for weeks,,, so you see, not everything works well for everyone.. I'd certainly sit down with your doc and discuss the Black Box Warning on Cymbalta and ask your doc if he knows about that and why he is giving it to you and perhaps there is a different ssri you can take at least while you are on tx.. Has he checked your liver functions tests frequently? I'd say

that if you are on this med and on treatment at the same time,, I'd want tests done either weekly or bi-weekly to make sure you catch any problem before it gets out of hand.. Our livers are the one thing that can regenerate thank goodness but who wants to damage it further... Here is a URL that you can go and read about Cymbalta ,, please scroll down the the Warning area and you can read for yourself,,, http://pi.lilly.com/us/cymbalta-pi.pdf I tried to copy and past just the pertinent info but it wouldnt let me copy it so you will have to go and read for yourself.. Ill post another article about cymbalta to follow this ,, jaxJurydoctor@... wrote: I have been on cymbalta pre treatment and now during treatment. Now I hear cymbalta is not good for my liver? I found cymbalta was better than zoloft. why is cymbalta bad? (some folks take it for fybromyalgia, too) amy See what's free at AOL.com. Jackie

December 22, 2007

Hi, I take Cymbalta.It does help with pain although at times I have to

take opiates as well. I also take it for depression.

For me the weight gain is controversial. I have gained weight on it but

I don't feel as hungry as on some other meds.

Gail

Richman, Judith A. wrote:

>

> Hi,

>

> I'm wondering if anyone tried Cymbalta to treat pain (not depression) and

> if so, whether it helped?

>

> I had been on Lyrica for FM pain and it totally wiped out the pain, which

> was a godsend. But, the side-effects involved a degree of weight gain

> which made me quit. I'm on vacation/out of town, but am planning to make

> an appt with my doctor when I return home, hoping to try Cymbalta. But I

> thought I'd first ask if anyone on this list has found it helpful for FM

> pain. When my doctor prescribed the Lyrica, she said that both should help

> with pain, but since I did not have depression, she chose Lyrica. She had

> not mentioned the side effect of weight gain. The listed side effects of

> Cymbalta include loss of appetite, which would be very welcome to me!

>

> Thanks for any input,

>

> Judy

>

December 22, 2007

HI,

I am on 90mg of Cymbalta as well as 150mg of Lyrica. I also have

depression. However it's hard at times to know which medication is

helping the most because my pain get so bad even taking taking all my

meds don't seem to work. I wouldn't want to know what it would be like

if I didn't have any of them. I also take Tramadol 50mg.and Skelaxin

800mg for pain. I have gain some weight, but I am over the strep

throat I just caught I am going to start a daily exercise program for

my self. I hear that's the best thing to do, even if we are in the

worst pain we should at least walk. I hope this helps, not every med

works for everyone, but I also have deficiencies which can pose a

problem for me. But I do what I can and keep up with all my meds. Just

wished there wasn't so many I had to take lol. But yes Cymbalta does help.

Bonny

>

> Hi,

>

> I'm wondering if anyone tried Cymbalta to treat pain (not

depression) and

> if so, whether it helped?

>

> I had been on Lyrica for FM pain and it totally wiped out the pain,

which

> was a godsend. But, the side-effects involved a degree of weight gain

> which made me quit. I'm on vacation/out of town, but am planning to make

> an appt with my doctor when I return home, hoping to try Cymbalta. But I

> thought I'd first ask if anyone on this list has found it helpful for FM

> pain. When my doctor prescribed the Lyrica, she said that both

should help

> with pain, but since I did not have depression, she chose Lyrica.

She had

> not mentioned the side effect of weight gain. The listed side effects of

> Cymbalta include loss of appetite, which would be very welcome to me!

>

> Thanks for any input,

>

> Judy

>

December 23, 2007

Hi,

I have been on Cymbalta since it first came out. I thought it wasn't helping

but then when I went off I had aches and pains in places I didn't even realize I

had! I am also on Wellbutrin. It seems like the combo of the two has helped

even more than the cymbalta alone. After being on both for a couple of weeks I

began to think better and even see more clearly.

I think the combo helped because Cymbalta helps with the

serotonin/norepinephrine and the Wellbutrin helps with the dopamine, which is

also deficient when you have cfs/me.

I am also on Lyrica and take ibubrpfen and vicodin as a backup.

My best friend and I both have fibro. Our motto is, " We say Yes to Drugs. "

(haha) I think anything, herbal or medicinal, that helps one have a better

life, is good.

P.S. Also on valcyte too. Please look at the new group for people on

Valcyte or thinking on going on Valcyte, here's the link:

Valcyte/

Sincerely, Jody

Jody

December 23, 2007

I started cymbalta 60mg 2 1/2 months ago, for depression, but also for the

benefit of helping with pain. It has helped me a GREAT deal with my mood, it's

been a godsend for sure! I think it's helped some with pain too, though most of

my pain is at night laying down. At night I take the cymbalta (can make you

drowsy), 50mg trazodone and 1/4 soma. I just asked my GP this week if raising

the dose could help produce more benefits and she said yes. I tried 90mg for one

night but it knocked me out pretty good and I was draggy so I'm putting off

trying it again for another few weeks, need to add in some other stuff now, like

mercury chelation med. Regarding weight, I've always been tall and thin and

though it could have been the stress of moving across country, I have not been

as hungry, so the side effect of losing or controlling weight would be helpful

for some people. I would definitely give it a try.

I did try lyrica a couple years ago for pain, and gained a little weight but

what bothered me the most was the uncomfortable bloating and I think some other

side effects though now I can't remember.

Good luck!

~Stacey

---------------------------------

Be a better friend, newshound, and know-it-all with Mobile. Try it now.

December 24, 2007

i have been on cymbalta for 3 years or so. i use it to reduce panic

attacks, associated with cfs. My dr. explains that it is a very good

med for cfs/fm because it does reduce pain and muscles aches. I

still have occassional joint pain (knees, ankles, et al.) It is

supposed to help mood, and general achiness, works well to prevent

panic attacks, and is supposed to have the fewest of side effects.

As patients with cfs/me/or fm we probably know more about side

effects than most do. I haven't really noticed weight gain (not more

than 10 lbs. or so) but it sure is hard to lose any. Although that

may or may not : ) be from the med. Watch out for the withdrawal

effects from cymbalta though (my dr. says there's not supposed to be

any such thing with this med) (let me assure you, he's wrong!) don't

stop suddenly! taper off very slowly if you intend to stop this med.-

-- In , " Richman, Judith A. "

<JRichman@...> wrote:

>

> Hi,

>

> I'm wondering if anyone tried Cymbalta to treat pain (not

depression) and

> if so, whether it helped?

>

> I had been on Lyrica for FM pain and it totally wiped out the pain,

which

> was a godsend. But, the side-effects involved a degree of weight

gain

> which made me quit. I'm on vacation/out of town, but am planning to

make

> an appt with my doctor when I return home, hoping to try Cymbalta.

But I

> thought I'd first ask if anyone on this list has found it helpful

for FM

> pain. When my doctor prescribed the Lyrica, she said that both

should help

> with pain, but since I did not have depression, she chose Lyrica.

She had

> not mentioned the side effect of weight gain. The listed side

effects of

> Cymbalta include loss of appetite, which would be very welcome to

me!

>

> Thanks for any input,

>

> Judy

>

December 26, 2007

Another option is d-phenylalanine. Some info here.

_http://www.aminoacidpower.com/osc/product_info.php?cPath=3_23 & products_id=171

_

(http://www.aminoacidpower.com/osc/product_info.php?cPath=3_23 & products_id=171)

Posted by: " cheriee111 " _cheriee@... _

(mailto:cheriee@...?Subject= Re:%20Cymbalta) _cheriee111 _

(cheriee111)

Wed Dec 26, 2007 6:35 pm (PST)