Re: Marijuana again

[Guest guest]

Don't worry Rainbow.

I'll do the remembering for both of us.

Tom

Administrator

> Tom: " Marijuana again tied to memory problems "

Here we go again!

What were we talking about?

Rainbow

[Guest guest]

> Tom: "I'll do the remembering for both of us."Oh, good!  Rainbow

[Guest guest]

Cannabis has been used for treatment of cancer and other diseases for a very

long time. See the movie " Can Cannabis Cure Cancer " which was recently

released. You can find it on You Tube. We have cannabanoid receptors naturally

occurring in our bodies. Not a direct answer, but the beginning of one.

Marijuana again

Hi all, I wanted to bring this subject up again.

I obtained so marijuana 4 days ago. Since then each evening I have been able to

eat and drink ok after smoking a joint.

I never did drugs before, I am not a proponent of them either. But I have just

had 2 bowls of corned beef hash, 5 biscuits, some peaches in custard and a drink

of grape juice. Everything has gone down. I am still eating soft food but with

no effort at all. In the daytime when working it is back to problem eating,

regurge etc.

I get more spasms at night but this is because my E is empty and I just eat a

cracker and it goes away. I am going to try this on Friday and Saturday nights

and I will keep a chart, cant beat a good statistic.

Anyone else got any feedback on this?

Stu

[Guest guest]

Stuart wrote:

>

> Anyone else got any feedback on this?

>

I have no experience to share but there is this:

Localization of mGluR5, GABAB, GABAA, and cannabinoid receptors

on the vago-vagal reflex pathway responsible for

transient lower esophageal sphincter relaxation in humans:

an immunohistochemical study.

Department of Gastroenterology, Academic Medical Center, Amsterdam, The

Netherlands.

" KEY RESULTS: MGluR5, GABA(, CB1, and CB2 receptors are abundantly

expressed in neurons of the myenteric plexus of the LES, nodose ganglion

cell bodies and nerve fibers, the dorsal motor nucleus, and nucleus of

the solitary tract in the brain stem. ... CONCLUSIONS; INFERENCES: Human

mGluR5, GABA(A,, and CB(1,2) receptors are abundantly expressed along

the vago-vagal neural pathway and involved in the triggering of TLESRs. "

CB1 and CB2 are cannabinoid receptors. TLESRs are transient lower

esophageal sphincter (LES) relaxations. The LES, myenteric plexus, and

Vagal neural path way are all important for swallowing. The interest

related to TLESRs is that cannabinoids seem to reduce them which can

useful for people with GERD. That isn't much help for us though,

however, it shows they are affecting the system that controls the LES.

Effect of ?9-tetrahydrocannabinol, a cannabinoid receptor agonist,

on the triggering of transient lower oesophageal sphincter relaxations

in dogs and humans

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697772/

" In humans, ?9-THC significantly reduced basal lower oesophageal

sphincter pressure. "

Now that, " reduced basal lower oesophageal sphincter pressure " could be

important for some with achalasia, depending on how high their pressures

is and how much it reduces it.

There seems to be some potential there, but there are 66 known

cannabinoids in cannabis and they are a mixed bag. Some work in opposite

ways. Also, the effects are not all positive for our purpose, besides

the mind issue. They can reduce GI motility and slowing the emptying of

the stomach. THC in large doses can make people nauseated and chronic

use of pot has caused cases of cyclic vomiting and hyperemesis, which is

probably rare and only with long-term use.

Cannabinoid hyperemesis: a case series of 98 patients.

http://www.ncbi.nlm.nih.gov/pubmed/22305024

Cannabinoids certainly do affect the GI system, including but not

limited to the esophagus. I see potential for us in research to develop

drugs that could help us without the negative effects. There is one

cannabinoid on the market in the US, Marinol (Dronabinol), there or more

choices in some other countries. Marinol is pharmaceutical THC (one of

the 66 cannabinoids in cannabis). It is used to prevent nausea and also

in some disorders like MS for pain. If you have a doctor you trust to be

able to handle the topic you could ask. I think it could be a hard sell

though. Many doctors would suspect you just want to get high. Those that

would understand would probably want you to try other medications first

before putting more Marinol out in the public.

notan

[Guest guest]

Thanks notan, that seems to be conclusively non-conclusive. But It does state

that certain cannabinoids may reduce the Lower Les pressure.

It may just be conincidental, but I lost about 7lb in fluids last week and was

struggling to get anything down. This week is the best I have been in a year.

I actually drank I drink of cold juice like a thirsty child and it was the best

feeling in months.

Stu McCormick

Mobile Inventory Program Limited

0845 680 7976

Mob 07966 695982

On 4 Jun 2012, at 22:00, notan ostrich <notan_ostrich@...> wrote:

> Stuart wrote:

> >

> > Anyone else got any feedback on this?

> >

>

> I have no experience to share but there is this:

>

> Localization of mGluR5, GABAB, GABAA, and cannabinoid receptors

> on the vago-vagal reflex pathway responsible for

> transient lower esophageal sphincter relaxation in humans:

> an immunohistochemical study.

> Department of Gastroenterology, Academic Medical Center, Amsterdam, The

> Netherlands.

> " KEY RESULTS: MGluR5, GABA(, CB1, and CB2 receptors are abundantly

> expressed in neurons of the myenteric plexus of the LES, nodose ganglion

> cell bodies and nerve fibers, the dorsal motor nucleus, and nucleus of

> the solitary tract in the brain stem. ... CONCLUSIONS; INFERENCES: Human

> mGluR5, GABA(A,, and CB(1,2) receptors are abundantly expressed along

> the vago-vagal neural pathway and involved in the triggering of TLESRs. "

>

> CB1 and CB2 are cannabinoid receptors. TLESRs are transient lower

> esophageal sphincter (LES) relaxations. The LES, myenteric plexus, and

> Vagal neural path way are all important for swallowing. The interest

> related to TLESRs is that cannabinoids seem to reduce them which can

> useful for people with GERD. That isn't much help for us though,

> however, it shows they are affecting the system that controls the LES.

>

> Effect of ?9-tetrahydrocannabinol, a cannabinoid receptor agonist,

> on the triggering of transient lower oesophageal sphincter relaxations

> in dogs and humans

> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697772/

> " In humans, ?9-THC significantly reduced basal lower oesophageal

> sphincter pressure. "

>

> Now that, " reduced basal lower oesophageal sphincter pressure " could be

> important for some with achalasia, depending on how high their pressures

> is and how much it reduces it.

>

> There seems to be some potential there, but there are 66 known

> cannabinoids in cannabis and they are a mixed bag. Some work in opposite

> ways. Also, the effects are not all positive for our purpose, besides

> the mind issue. They can reduce GI motility and slowing the emptying of

> the stomach. THC in large doses can make people nauseated and chronic

> use of pot has caused cases of cyclic vomiting and hyperemesis, which is

> probably rare and only with long-term use.

>

> Cannabinoid hyperemesis: a case series of 98 patients.

> http://www.ncbi.nlm.nih.gov/pubmed/22305024

>

> Cannabinoids certainly do affect the GI system, including but not

> limited to the esophagus. I see potential for us in research to develop

> drugs that could help us without the negative effects. There is one

> cannabinoid on the market in the US, Marinol (Dronabinol), there or more

> choices in some other countries. Marinol is pharmaceutical THC (one of

> the 66 cannabinoids in cannabis). It is used to prevent nausea and also

> in some disorders like MS for pain. If you have a doctor you trust to be

> able to handle the topic you could ask. I think it could be a hard sell

> though. Many doctors would suspect you just want to get high. Those that

> would understand would probably want you to try other medications first

> before putting more Marinol out in the public.

>

> notan

>

>

[Guest guest]

Stuart wrote:

>

> Thanks notan, that seems to be conclusively non-conclusive. But It

> does state that certain cannabinoids may reduce the Lower Les pressure.

>

Right, and I don't know of any good studies of actually using marijuana

with achalasia. Also, some drugs don't work the same in achalasia as

they do in the general population. There are some old messages in which

some members have said it helped them. I think there is also at least

one that said it didn't. Not much to go by there. I expect it does have

an effect but how well it works probably depends on the pressure at the

LES before using it. Drugs that reduce the pressure at the LES work for

some people with achalasia and not for others, because in some they

don't reduce the pressure enough, and some have more problems than just

LES pressure. We are not all the same. Like anything that works by

affecting the LES if there are other problems stopping food like a

kinked sigmoid esophagus it is unlikely to do anything for the kink, so

results could vary. You can find a number of people on the internet by

searching that think it helps, but you can find people that think all

kinds of quackery works too. It is hard to predict what it will do for

you or not.

notan

[Guest guest]

There is something more I want to say on this subject, but first let me

say something else.

It is hard, and probably a mistake to trust any research completely. I

usually assume that goes without saying. It is especially unwise to

trust research on political subjects and that includes political drugs.

There is a lot of fraud, spin and wishful thinking that gets published

as research results. In the case of political drugs, both researchers

for and against the use of them have been know to knowingly commit fraud

in behalf of their causes.

The main thing I want to discuss is the children. Children have

achalasia and children read the messages of this group. They may read

these topics here, but this topic also exists scattered all over the

internet. If they are going to be on the internet they are likely to

run into this topic somewhere. If you have a child that has achalasia

the idea that some people think marijuana may help them is probably

going to become part of their lives. The genie is out of the bottle

whether it works or not for them. Hopefully they will have gained wisdom

from the adults around them before they have to deal with it on their

own. So, this is to the parents out there, figure out what you are going

to teach your children, before they jump to their own conclusions.

Back in the 70s the 1936 anti-marijuana movie, Reefer Madness, found new

life and was shown on college campuses to crowds of students, often

while many were under the influence, as a side splitting comedy. What

was seen as credible drug information by the authors in 1936 was seen as

hilarious goofiness in the 1970s. I had never used any marijuana but I

went to the movie and left realizing what many of those kids must have

thought of the credibility of some of their parents who where still of

that 1936 mentality on the subject. The rolling laughter was proof to me

that some of what I though was credible was not, and I too had looked

like a joke to some of the friends I had been preaching to.

Whatever you tell your children try to be sure it is credible. If your

main concern is the Law, or employment issues, then don't resort to

preaching about drugs making holes in the brain. It is probably best to

stick with what life has actually taught you and not rely on

questionable authorities on either side.

notan