Re: Ken-Niacin Question -The toxicity of Slo-Niacin

[Guest guest]

Thanks for your input! I agree with you. The Niacin was

probably the triggering factor.

Sorry for the delayed response. I am trying to keep a job.

Quite an adventure! So I have very little energy left. The Imuplus

is helping a ton though.

> Thanks for coming out of the shadows!

>

> First: to explain what you are talking about:

>

> " comparison of sustained-release (SR) and immediate-release (IR)

niacin "

>

> In recent years, numerous case reports have described

hepatotoxicity linked to high-dose niacin therapy; almost all the

patients were taking SR niacin.

>

> A number of products have been implicated in niacin-induced

hepatotoxicity, including two prescription products: Nicobid from

Rhone-Poulenc Rorer (Collegeville, PA) and Slo-Niacin from Upsher-

(Minneapolis). " http://www.pharminfo.com/pubs/msb/niacin.html

>

> The IR niacin is the one that produces the Niacin Flush, the SR

niacin uses a " unique, patented polygel® controlled-release

delivery

system. " http://www.upsher-smith.com/products/sloniacin.html

>

> " Slow release formulations of niacin are not as attractive as they

may seem,

> since they are metabolized differently to more toxic, less

effective metabolites

> (3). " - 3. Stern RH, Freeman DJ, Spence JD: Differences in

Metabolism of Time-

> Release and Unmodified Nicotinic Acid: Explanation of the

Differences in

> Hypolipidemic Action? Metabolism 1992;41:879-881.

> Cited at http://www.pharminfo.com/pubs/msb/niacin_lttr.html

>

> As an FYI:

> " To overcome the side effects of niacin, if it is taken with

Vitamin C, or with plain Orange Juice, the flushing, burning and

tingling will either not occur or will be minimized greatly. "

>

>

> The sustained release means that the body may not have an

opportunity to 'back-flush' or normalize after the exposure (similar

to milk thistle which should only be taken once a day). This could be

why the problems developed.

> See http://www.gate.net/~shipbrk/Co$/narconon/niacin.html for cases

where SR produced problems within a week and IR did not (with the

same people) - and speculation as to the mechanism

>

> So, bottom line: SR does not give the blood vessel an opportunity

to expand and then contract (like regular niacin) but keeps them

expanded for a prolonged interval ... this continuous state may be

how CFIDS and other items are caused.

>

> So, in my humble opinion -- it would stress the body and thus open

the gate for CFIDS to enter....

>

> M Lassesen, M.S.

> ex " Dr.Gui (MSDN) " , " Dr. VB "

> cv: http://www.folkarts.com/kenl/ KenL@e...

> Phone: 360 297.4717 Cell: 360 509.8970 Fax 520 832.6836

> Re: Niacin Question -The toxicity of

Slo-Niacin

>

>

> I got sick when I was in a 3 month treatment with slo-niacin with

an

> MD. That is the time when I got sudden onset CFIDS. In the back

> of my mind is the question:

>

> Taking 4 full grams of slo-niacin, what can that do to a normal

> person?

>

> The answer I found in the internet posting " The toxicity of Slo-

> Niacin " (if you search that text you will find it).

>

> Slo-Niacin which is not normal Niacin is very toxic. Besides

> causing liver failure in several people studied, it caused

> CHRONIC FATIGUE on others. That peaked my curiosity. What is the

> slo in slo-niacin? Since Cfids involves blood vessel dilation and

> contraction, how could this relate to slo-niacin or niacin?

>

> Can the compound that makes the slow release hang around and

> mess up our dilation response? Is this something that could

> cause CFIDS?

>

> I get chest pains when I take Niacin now at 200mg or more. This

> kind pains started to appear before the sudden onset also.

They

> feel the same.

>

> Sometimes I think that the high dose of Slo-niacin is linked

> to my sudden onset.

>

> Just a thought.

>

>

>

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