Re: Re: Jim C. - Goldstein drugs

[Guest guest]

Jim,

Goldstein has over 100 drugs that he uses and everyone responds differently

based on their unique genetics. For me, Nimodipine or Nimotop was the most

effective and longest lasting (3-4 months before effects gradually began to

wear off). it completely eliminated my symptoms within 30 minutes. A

Dopamine nasal spray Dr. Goldtein compounds also worked within minutes but I

built up a tolerance to this drug quickly. Some people respond within

seconds to low doses of nitroglycerine, ketamine nasal spray and eye drops.

You can't tell what will work on a patient. You spend of the day in his

office and take a new drug every hour until he finds one that will work for

you. Unfortunately, as I said, you build up a tolerance and gradually your

symptoms return. He has a list of all his drugs on his web site. I'll try

to post it if I can find it. Hud knows the site so you may want to ask him.

Steve B.

Re: Rich - Mitochondrial hypothesis

>

> Hi ,

>

> What is the drug that you were prescribed that provided the

> immediate relief (within 30 min.) Have many other PWCFS responded as

> favorably to this drug? Also, how long lasting is the results?

>

> All the best,

> Jim

> clements@...

>

>

>

> > > > Jim and Jerry;

> > > >

> > > > While I have no quarrel with your NADH theory as it relates to

> > > > mitochondrial supplementation, I do have a problem with the

> > > following

> > > > hypothesis:

> > > >

> > > > " My own thinking is that the breakdown of the mitochondrial

> > > > processes is a result of lack of oxygen at the cell and/or an

> acidic

> > > pH

> > > > within the cell or mitochondria which interferes with the

> production

> > > of

> > > > ATP. "

> > > >

> > > > While in some cases, this hypothesis may well be true, it

> doesn't

> > > allow

> > > > for the fact that the " factory " itself (the mitochondria) may be

> > > > flawed. If there is an endemic flaw, then both the quantity and

> > > quality

> > > > of the citric acid cycle and the ATP cycle will be compromised!

> > > >

> > > > What I am trying to say here is that there can be damage to the

> > > > mitochondrion itself, damage caused either by the Mitochondria

> DNA

> > > > replication or the Nuclear DNA which affects the " control " of

> the

> > > > Mitochondrial function .... and directly affects the function of

> > > Complex

> > > > II of the mitochondrial process " factory " or " train " .

> > > >

> > > > The reason I came back to this list, at Christie's request, was

> to

> > > alert

> > > > everyone to the possibility of mitochondrial dysfunction as

> being

> > > the

> > > > " source " of the problem. Some may have viral source, or other

> > > sources,

> > > > but do not discount the possibility that the " factory " itself

> may be

> > > the

> > > > problem! I am including, below, " Criteria for Mito and

> Guidelines

> > > for

> > > > when to suspect Mito "

> > > >

> > > > Jean

> > > >

> > > > **********

> > > >

> > > > Criteria for Mitochondrial Disease

> > > >

> > > >

> > > > Think mitochondrial disease when:

> > > >

> > > > 1. A " common disease " has atypical features that set it apart

> from

> > > the

> > > > pack.

> > > > 2. Three or more organ systems are involved.

> > > > 3. Recurrent setbacks or flares in a chronic disease occur with

> > > > infections.

> > > >

> > > >

> > > > Diagnostic testing for mitochondrial disease:

> > > >

> > > > 1. Blood for mtDNA (PCR and Southern)

> > > > 2. Blood and CSF for Lactate and Pyruvate, or Brain MR

> > > > Spectroscopy.

> > > > 3. Urine Organic Acids (by GC/MS).

> > > > 4. Plasma and Urine Amino Acids.

> > > > 5. Blood and Urine Carnitine.

> > > > 6. Brain MRI.

> > > > 7. Muscle biopsy and skin biopsy:

> > > > * Neuropathology and Electron Microscopy

> > > > * Mitochondrial Electron Transport Studies

> > > > * Fresh (coupled) Mitochondrial Polargraphy

> > > > * Muscle mtDNA (PCR and Southern)

> > > >

> > > > ( Naviaux M.D., Ph.D.)

> > > >

> > > > As far as diagnostic tests go, they suggest you have the first 5

> > > before

> > > > going on, as these are relatively cheap and non-invasive and can

> > > give

> > > > you a good idea of whether you are going in the right direction.

> > > >

> > > >

> > > >