Antiviral Pathway Activation in Patients with CFS

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[CO-CURE] RES: Antiviral Pathway Activation in Patients with

Chronic Fatigue Syndrome and Acute Infection

> Antiviral Pathway Activation in Patients with Chronic Fatigue Syndrome

> and Acute Infection.

>

> Journal: Clin Infect Dis 2001 Nov 6;33(12) [epub ahead of print]

>

> Authors: Gow JW, Simpson K, Behan PO, Chaudhuri A, McKay IC, Behan WM.

>

> Affiliation: Department of Neurology, University of Glasgow, Scotland,

> United Kingdom.

>

> NLM Citation: PMID: 11698994

>

> Gene expression of key enzymes in 2 antiviral pathways (ribonuclease

> latent [RNase L] and RNA-regulated protein kinase [PKR]) was compared in

> 22 patients with chronic fatigue syndrome (CFS), 10 patients with acute

> gastroenteritis, and 21 healthy volunteers.

>

> Pathway activation in the group of patients with infections differed

> significantly from that of the other 2 groups, in whom there was no

> evidence of upregulation.

>

> Therefore, assay of activation is unlikely to provide the basis for a

> diagnostic test for CFS.

>

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