Chromosomes 13, 7 May Be Linked to Autism / Sacramento: KCRA Vaccine Safe Tonite

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Chromosomes 13, 7 May Be Linked to Autism / Sacramento: KCRA Vaccine Safe

Tonite

Thursday, December 09, 1999

Reuters Health - A previously unreported region on chromosome 13 may

contain a gene associated with autism, according to US-based investigators

participating in the Collaborative Linkage Study of Autism.

The investigators also confirmed previously reported data suggesting

that a region on chromosome 7 may be involved in the etiology of the disease

as well.

Dr. E. Folstein, of the New England Medical Center in Boston,

Massachusetts, and a multicenter team searched for genes related to autism

in 75 families with at least two children afflicted with the condition. The

team used 416 short tandem repeat polymorphic markers.

Two regions in chromosome 13, D13S800 and the area between D13S217 and

D13S1229, showed the strongest links to autism. The investigators linked

approximately 35% of the families to D13S800 under an autosomal recessive

model of autism and 33% to the latter region.

The chromosome 7 region, D7S1813, had the next highest score. The

investigators found that 29% of the families were linked to this site. This

confirmed the results of a International Molecular Genetic Study of Autism

Consortium study that found evidence of a gene related to autism near this

region, the authors note. Another previous study indicated that a gene

related to speech and language disorder reside close by.

" In summary, " Dr. Folstein's team writes in the December 15th issue of

the American Journal of Medical Genetics, " we have identified evidence for

linkage to a previously unreported region on chromosome 13, and obtained

evidence in support of a previously implicated region on chromosome 7. "

They add that " [t]hese regions and others will be followed up in the

second stage of our study by typing additional markers in both the original

and a second set of identically ascertained autism families. "

Am J Med Genet 1999;88:000-000.

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Sacramento: Vaccine Safety Story on KCRA Tonite Finally!

The much awaited and delayed news piece on vaccine safety will air

tonight at 6:00 pm on Sacramento's NBC affiliate KCRA Channel 3. It was

initially scheduled to run Dec. 7, but was bumped until tonight.

Parent advocate Rick Rollens was interviewed for the story a few week's

ago. In addition, he supplied them with a video copy of his poignant

testimony before Congress last August.

Kathi with National Vaccine Information Center (NVIC)

contacted a local member of NVIC, Satterfield, whose son was vaccine

damaged and has been compensated through the Vaccine Injury Compensation

Program. used to live in Citrus Heights and now lives in Petaluma.

Having spent some time with her, Rollens is " sure she will present a very

compelling story. "

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