Re: Rich/Neutrophil Alk. Phos Score

[Guest guest]

In a message dated 1/31/2006 10:27:08 P.M. Pacific Standard Time,

richvank@... writes:

Hi, .

Alkaline phosphatase and bilirubin are two substances that the liver

normally puts into the bile, and they are carried into the

intestine. If the bile ducts are blocked, even a little, the

alkaline phosphatase level will rise in the blood. If bilirubin is

also high in the blood, this suggests that the bile duct system is

blocked to some degree at least, such as by one or more gallstones,

or that there is other liver disease going on. I don't know how the

neutrophils came into it. Neutrophils are the most abundant type of

white blood cell. If they rise in the blood, it is a sign of

infection. If your gallstones are causing an infection in your

gallbladder, the neutrophils might rise.

Rich

Dear and Rich

The Neutrophil alkaline phosphatase NAP is a specialized test to

differentiate certain white blood cell abnormalities.

It differentiates chronic myeloid leukaemia (low NAP ) from reactive

leucocytosis (high), eg, bacterial infection.

It may assist in the differentiation of polycythaemia vera (PV) (high), the

diagnosis of paroxysmal nocturnal haemoglobinuria (very low); it is normal

to high in other anaemias. The NAP is also moderately elevated in pregnancy,

with oestrogen therapy (eg, oral contraception) and corticosteroid therapy.

Serum alkaline phosphatase (AP) is different, it is a common lab test used

to determine abnormalities of bone turnover, abnormal bone changes or

metastatic disease , and as AP is passed out of the body in the bile, blockage

of

the bile duct in the liver will cause AP elevation. A peculiar alkaline

phosphatase (the Regan enzyme) is seen in lung cancer

regards

Enlander MD

[Guest guest]

Thank you so much to both Rich and ,

My T bilirubin and C bilirubin in my last blood tests were within normal

range.

If I had a blockage in the bile duct,even a little.Wouldn't I experience the

obvious severe right sided pain?

Would an ultrasound pick up the blockage?

Who do I need to see beyond my GP for more information?

What do you think I should do.Is the diet you suggested Rich enough?

I often get bouts of terrible nausea,belching etc but it's not always

followed by eating oily food(which I rarely do).

Actually sometimes it occurs when I wait too long to eat and by then no

matter what I eat makes me ill.

It takes days if not weeks to get my stomach back on track.I have drawers

full of antacids,they don't help

The only thing that seems to pull me out of it is if I eat very plain food

for some time.

White rice,potatoes,bananas,yoghurt.Oddly enough cream.

As for gallstone flushing,with olive oil etc.Is it safe?does it really work?

Another result I had from a blood test taken in 2004 was for lactate

dehydrogenase isoenzymes.All was ok except for

LD 5 " liver " very slightly raised.

the report read

The pattern is suggestive of possible skeletal muscle or hepatic

disturbance.

Cheers

>

> Hi, .

>

> Alkaline phosphatase and bilirubin are two substances that the liver

> normally puts into the bile, and they are carried into the

> intestine. If the bile ducts are blocked, even a little, the

> alkaline phosphatase level will rise in the blood. If bilirubin is

> also high in the blood, this suggests that the bile duct system is

> blocked to some degree at least, such as by one or more gallstones,

> or that there is other liver disease going on. I don't know how the

> neutrophils came into it. Neutrophils are the most abundant type of

> white blood cell. If they rise in the blood, it is a sign of

> infection. If your gallstones are causing an infection in your

> gallbladder, the neutrophils might rise.

>

>

> Rich

>

>

> Dear and Rich

>

> The Neutrophil alkaline phosphatase NAP is a specialized test to

> differentiate certain white blood cell abnormalities.

> It differentiates chronic myeloid leukaemia (low NAP ) from reactive

> leucocytosis (high), eg, bacterial infection.

> It may assist in the differentiation of polycythaemia vera (PV) (high),

> the

> diagnosis of paroxysmal nocturnal haemoglobinuria (very low); it is

> normal

> to high in other anaemias. The NAP is also moderately elevated in

> pregnancy,

> with oestrogen therapy (eg, oral contraception) and corticosteroid

> therapy.

> Serum alkaline phosphatase (AP) is different, it is a common lab test

> used

> to determine abnormalities of bone turnover, abnormal bone changes or

> metastatic disease , and as AP is passed out of the body in the bile,

> blockage of

> the bile duct in the liver will cause AP elevation. A peculiar

> alkaline

> phosphatase (the Regan enzyme) is seen in lung cancer

> regards

> Enlander MD

[Guest guest]

Hi, .

Alkaline phosphatase and bilirubin are two substances that the liver

normally puts into the bile, and they are carried into the

intestine. If the bile ducts are blocked, even a little, the

alkaline phosphatase level will rise in the blood. If bilirubin is

also high in the blood, this suggests that the bile duct system is

blocked to some degree at least, such as by one or more gallstones,

or that there is other liver disease going on. I don't know how the

neutrophils came into it. Neutrophils are the most abundant type of

white blood cell. If they rise in the blood, it is a sign of

infection. If your gallstones are causing an infection in your

gallbladder, the neutrophils might rise.

Rich

>

> Rich or anybody who might know,

>

>

> This is one of those times when you read something but can't

recall where.

>

> Somewhere researching gallstones I recall reading mention of an

elevated Neutrophil Alk Phos score.

>

> From blood test results my score is always just above the

reference range.

> No doctor has ever told me what this test is for and why they are

not concerned that my score is not within the norm.

>

> Can you help me with this one?

>

>

> Best

>

>

[Guest guest]

Hi, .

>

>

> Thank you so much to both Rich and ,

***Thanks to from me, too! I hadn't heard about neutrophil

alkaline phosphatase.

>

> My T bilirubin and C bilirubin in my last blood tests were within

normal

> range.

***That's good to hear. So you haven't turned yellow, either,

then,and your bile is currently able to get through your biliary

tract and into the duodenum without difficulty.

>

> If I had a blockage in the bile duct,even a little.Wouldn't I

experience the

> obvious severe right sided pain?

***Yes, I think you would.

>

> Would an ultrasound pick up the blockage?

***Yes. An ultrasound exam can exclude blockage of bile ducts. It

can also detect gallstones as small as 2 mm in size, and the false

negative and false positive rates when it is done at major medical

centers are as low as 2 to 4%.

>

> Who do I need to see beyond my GP for more information?

***You might try a liver specialist.

> What do you think I should do. Is the diet you suggested Rich

enough?

***If I were in your position, I think I would try to dissolve the

stones in place using the diet and the supplements.

> I often get bouts of terrible nausea,belching etc but it's not

always

> followed by eating oily food(which I rarely do).

***According to the medical books, these are not reliable indicators

that the gallstones are causing problems.

> Actually sometimes it occurs when I wait too long to eat and by

then no

> matter what I eat makes me ill.

> It takes days if not weeks to get my stomach back on track.I have

drawers

> full of antacids,they don't help

>

> The only thing that seems to pull me out of it is if I eat very

plain food

> for some time.

> White rice,potatoes,bananas,yoghurt.Oddly enough cream.

***The cream is very interesting. I think that would for sure

provoke some bile release from the gall bladder.

>

> As for gallstone flushing,with olive oil etc. Is it safe? does it

really work?

***I think this is kind of controversial. We have had people report

to the list that they did this and actually retrieved hard stones

from their stools afterward. On the other hand, Drs. Murray

and Pizzorno in the Encyclopedia of Natural Medicine say that

these are not really gallstones, but " a soft, saponified complex of

minerals, olive oil and lemon juice produced within the

gastrointestinal tract. " Also, I do think there's the possibility

of blocking the cystic duct or the common bile duct if the stones

are of the right size to do so.

>

> Another result I had from a blood test taken in 2004 was for

lactate

> dehydrogenase isoenzymes.

All was ok except for

> LD 5 " liver " very slightly raised.

> the report read

> The pattern is suggestive of possible skeletal muscle or hepatic

> disturbance.

***If it was not very high, and there is only one test result

showing it's high, it's hard to put much weight on it.

>

> Cheers

***Cheers to you, too, ! Sorry that this is not an easy thing

to resolve.

***Rich

>

>

> >

> > Hi, .

> >

> > Alkaline phosphatase and bilirubin are two substances that the

liver

> > normally puts into the bile, and they are carried into the

> > intestine. If the bile ducts are blocked, even a little, the

> > alkaline phosphatase level will rise in the blood. If bilirubin

is

> > also high in the blood, this suggests that the bile duct system

is

> > blocked to some degree at least, such as by one or more

gallstones,

> > or that there is other liver disease going on. I don't know

how the

> > neutrophils came into it. Neutrophils are the most abundant

type of

> > white blood cell. If they rise in the blood, it is a sign of

> > infection. If your gallstones are causing an infection in your

> > gallbladder, the neutrophils might rise.

> >

> >

> > Rich

> >

> >

> > Dear and Rich

> >

> > The Neutrophil alkaline phosphatase NAP is a specialized test

to

> > differentiate certain white blood cell abnormalities.

> > It differentiates chronic myeloid leukaemia (low NAP ) from

reactive

> > leucocytosis (high), eg, bacterial infection.

> > It may assist in the differentiation of polycythaemia vera (PV)

(high),

> > the

> > diagnosis of paroxysmal nocturnal haemoglobinuria (very low);

it is

> > normal

> > to high in other anaemias. The NAP is also moderately elevated

in

> > pregnancy,

> > with oestrogen therapy (eg, oral contraception) and

corticosteroid

> > therapy.

> > Serum alkaline phosphatase (AP) is different, it is a common lab

test

> > used

> > to determine abnormalities of bone turnover, abnormal bone

changes or

> > metastatic disease , and as AP is passed out of the body in the

bile,

> > blockage of

> > the bile duct in the liver will cause AP elevation. A

peculiar

> > alkaline

> > phosphatase (the Regan enzyme) is seen in lung cancer

> > regards

> > Enlander MD

>

[Guest guest]

Hi, .

>

>

> Thank you so much to both Rich and ,

***Thanks to from me, too! I hadn't heard about neutrophil

alkaline phosphatase.

>

> My T bilirubin and C bilirubin in my last blood tests were within

normal

> range.

***That's good to hear. So you haven't turned yellow, either,

then,and your bile is currently able to get through your biliary

tract and into the duodenum without difficulty.

>

> If I had a blockage in the bile duct,even a little.Wouldn't I

experience the

> obvious severe right sided pain?

***Yes, I think you would.

>

> Would an ultrasound pick up the blockage?

***Yes. An ultrasound exam can exclude blockage of bile ducts. It

can also detect gallstones as small as 2 mm in size, and the false

negative and false positive rates when it is done at major medical

centers are as low as 2 to 4%.

>

> Who do I need to see beyond my GP for more information?

***You might try a liver specialist.

> What do you think I should do. Is the diet you suggested Rich

enough?

***If I were in your position, I think I would try to dissolve the

stones in place using the diet and the supplements.

> I often get bouts of terrible nausea,belching etc but it's not

always

> followed by eating oily food(which I rarely do).

***According to the medical books, these are not reliable indicators

that the gallstones are causing problems.

> Actually sometimes it occurs when I wait too long to eat and by

then no

> matter what I eat makes me ill.

> It takes days if not weeks to get my stomach back on track.I have

drawers

> full of antacids,they don't help

>

> The only thing that seems to pull me out of it is if I eat very

plain food

> for some time.

> White rice,potatoes,bananas,yoghurt.Oddly enough cream.

***The cream is very interesting. I think that would for sure

provoke some bile release from the gall bladder.

>

> As for gallstone flushing,with olive oil etc. Is it safe? does it

really work?

***I think this is kind of controversial. We have had people report

to the list that they did this and actually retrieved hard stones

from their stools afterward. On the other hand, Drs. Murray

and Pizzorno in the Encyclopedia of Natural Medicine say that

these are not really gallstones, but " a soft, saponified complex of

minerals, olive oil and lemon juice produced within the

gastrointestinal tract. " Also, I do think there's the possibility

of blocking the cystic duct or the common bile duct if the stones

are of the right size to do so.

>

> Another result I had from a blood test taken in 2004 was for

lactate

> dehydrogenase isoenzymes.

All was ok except for

> LD 5 " liver " very slightly raised.

> the report read

> The pattern is suggestive of possible skeletal muscle or hepatic

> disturbance.

***If it was not very high, and there is only one test result

showing it's high, it's hard to put much weight on it.

>

> Cheers

***Cheers to you, too, ! Sorry that this is not an easy thing

to resolve.

***Rich

>

>

> >

> > Hi, .

> >

> > Alkaline phosphatase and bilirubin are two substances that the

liver

> > normally puts into the bile, and they are carried into the

> > intestine. If the bile ducts are blocked, even a little, the

> > alkaline phosphatase level will rise in the blood. If bilirubin

is

> > also high in the blood, this suggests that the bile duct system

is

> > blocked to some degree at least, such as by one or more

gallstones,

> > or that there is other liver disease going on. I don't know

how the

> > neutrophils came into it. Neutrophils are the most abundant

type of

> > white blood cell. If they rise in the blood, it is a sign of

> > infection. If your gallstones are causing an infection in your

> > gallbladder, the neutrophils might rise.

> >

> >

> > Rich

> >

> >

> > Dear and Rich

> >

> > The Neutrophil alkaline phosphatase NAP is a specialized test

to

> > differentiate certain white blood cell abnormalities.

> > It differentiates chronic myeloid leukaemia (low NAP ) from

reactive

> > leucocytosis (high), eg, bacterial infection.

> > It may assist in the differentiation of polycythaemia vera (PV)

(high),

> > the

> > diagnosis of paroxysmal nocturnal haemoglobinuria (very low);

it is

> > normal

> > to high in other anaemias. The NAP is also moderately elevated

in

> > pregnancy,

> > with oestrogen therapy (eg, oral contraception) and

corticosteroid

> > therapy.

> > Serum alkaline phosphatase (AP) is different, it is a common lab

test

> > used

> > to determine abnormalities of bone turnover, abnormal bone

changes or

> > metastatic disease , and as AP is passed out of the body in the

bile,

> > blockage of

> > the bile duct in the liver will cause AP elevation. A

peculiar

> > alkaline

> > phosphatase (the Regan enzyme) is seen in lung cancer

> > regards

> > Enlander MD

>