Natural hormones/Liver pathways/Schaller

March 18, 2006

This is a great question.

Off the top, since I am tired, lets just say I have RARELY seen natural

hormones or their metabolites go too high without supplementation with

natural ones. I must say this has surprised me in light of all the junk the

liver handles.

I HAVE SEEN some folks VERY RARELY who are given very low doses of

bio-identical hormones like testosterone, progesterone and estriol, who get

bizarre high levels IF depleted liver processing agents well known to this

band, like NAC, glutathione, Glucuronate/etc, who got this way from

1) Chemotherapy

2) Massive petroleum toxin exposure

3) Very high dose and decades of multiple liver toxic medications

The most common are 1) and 2).

Best regards,

Schaller, MD

undisclosed location, undisclosed web sites, undisclosed location and no

financial ties to this material above

Rich/hormones processed thru

methylation/sulfation pathways?

> Are hormones, whether endogenous or exogenous, processed thru either

> the methylation or sulfation pathways? If so, then if someone has a

> block in either pathway, then the hormone will not be utlized by the

> body?

> Would transdermal creams, or injections, be subject to this same

> processing? (if hormones that are produced within the body go thru

> these pathways, then I would guess these forms would also?)

> Bottom line: if someone has a block in these pathways, then would any

> hormone, no matter its source, not going to be utilized by the body?

> Thanks for any thoughts on this. Les

>

> This list is intended for patients to share personal experiences with each

> other, not to give medical advice. If you are interested in any treatment

> discussed here, please consult your doctor.

>

March 19, 2006

Dr Schaller: thank you so much for this info. Since I would guess that many of

us DO have low levels of the liver processing agents, then taking low doses of

hormones might throw us for a loop, even if the lab test did not officially who

a high level? (but then, if that happens, we just back up and take a slightly

lower dose, I would guess, until we get a benefit without too much of an adverse

effect?) I would think, also, that balancing these hormones would be necessary

(perhaps dependent upon initial hormone testing results, and where the

deficiencies were noted, and what symptoms were present) in order to obtain

satisfactory results.

Personally, I am extremely low in all of these hormones, and can't help but

think that, if they were supplemented carefully and monitored, that this might

improve my quality of life (and hopefully my health). But, as you know, most drs

do not subscribe to supplementing with bioidentical hormones - Les