Article: Beneficial Effect of Brewers' Yeast Extract on Daily Activity in a Murine Model of CFS

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eCAM Advance Access originally published online on January 23, 2006

eCAM 2006 3(1):109-115; doi:10.1093/ecam/nek012

Beneficial Effect of Brewers' Yeast Extract on Daily Activity in a Murine

Model of Chronic Fatigue Syndrome

Takashi Takahashi1, Fei Yu1, Shi-jie Zhu1, Junji Moriya1, Hiroyuki Sumino4,

Shigeto Morimoto2,Nobuo Yamaguchi3 and Tsugiyasu Kanda1

1)Department of General Medicine, Kanazawa Medical University Ishikawa,

Japan,

2)Department of Geriatric Medicine, Kanazawa Medical University Ishikawa,

Japan,

3)Department of Serology, Kanazawa Medical University Ishikawa, Japan, and

4)Department of Medicine and Biological Science, Gunma University Graduate

School of Medicine Gunma, Japan

C The Author (2006). Published by Oxford University Press. All rights

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Abstract:

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The aim of this study was to assess the effect of Brewers' yeast extract

(BYE) on daily activity in a mouse model of chronic fatigue syndrome (CFS).

CFS was induced by repeated injection of Brucella abortus (BA) antigen every

2 weeks. BYE was orally administered to mice in a dose of 2 g per kg per day

for 2 weeks before injecting BA and for 4 weeks thereafter.

We evaluated daily running activity in mice receiving BYE as compared with

that in untreated mice. Weekly variation of body weight (BW) and survival in

both groups was monitored during the observation period. Spleen weight (SW),

SW/BW ratio, percent splenic follicular area and expression levels of

interferon- (IFN-) and interleukin-10 (IL-10) mRNA in spleen were determined

in both groups at the time of sacrifice.

The daily activity during 2 weeks after the second BA injection was

significantly higher in the treated group than in the control. There was no

difference in BW between both groups through the experimental course.

Two mice in the control died 2 and 7 days after the second injection,

whereas no mice in the treated group died. Significantly decreased SW and

SW/BW ratio were observed in the treated mice together with elevation of

splenic follicular area. There were suppressed IFN- and IL-10 mRNA levels in

spleens from the treated mice.

Our results suggest that BYE might have a protective effect on the marked

reduction in activity following repeated BA injection via normalization of

host immune responses.

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Full-Text article at:

http://www.cfsresearch.org/cfs/research/treatment/19.htm

For discussion on Research and Treatments for CFS/FM, take a look at:

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