Vitamin D

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Vitamin D May Lower Risk of Ovarian, Breast, Kidney, and Colon Cancers by Craig WeatherbyCourtesy of Vital Choice Seafood The evidence for vitamin D as a powerful cancer-preventer continues to grow at a rapid rate. The results of two new data analyses indicate that high dietary intake of the “sunshine-and-seafood” vitamin can cut the risk of colon and breast cancers by 50 percent. And these results follow the findings of two studies by the same team, which indicate that greater sun exposure cuts the risk of ovarian cancer – one of the most deadly kinds – and the risk of kidney cancer. Sun exposure produces vitamin D in the body, which is why greater sun exposure yields reduced cancer risks, overall: benefits that outweigh greatly the possible increase in skin cancer risk produced by over exposure to sun – especially in fair-skinned people -- and sun burn. The research team responsible for the new data analysis and related prior investigations included the world’s leading vitamin D scientists: * Professor

Giovannucci, M.D., Sc.D., of Harvard University.* Professor F. Holick, M.D., Ph.D. of Boston University.* Professors Gorham, Ph.D., C. Garland, Ph.D., and Cedric F. Garland, Dr. P.H. of the University of California San Diego.* B. Grant, Ph.D., founder of the Sunlight, Nutrition and Health Research Center in San Francisco (SUNARC). The encouraging new findings fit with the same team’s prior analysis of 63 studies of vitamin D status and cancer risk. That 2005 meta-analysis found that if people consumed more vitamin D, it could reduce their risks of breast, colon, and ovarian cancers by half (see “Higher Vitamin D Intake Could Cut Cancer Risk in Half”. And last

December, the same group published studies showing that low exposure to sunlight is linked to higher risk of ovarian and kidney cancer (Garland CF et al Am J Prev Med 2006; Mohr SB et al 2006). Both analyses employed previously unavailable data from a new World Health Organization database of cancer incidence, mortality and prevalence in 175 countries (GLOBOCAN). Vitamin D and breast cancer risk The UCAL San Diego team examined data from two large epidemiological studies -- the Nurses’ Health Study and the St. 's Hospital Study -- which included 1,760 women (Gorham ED et al 2007). Their analysis showed that the women with the highest blood levels of vitamin D -- 127 nanomoles per liter (nmol/l) -- were 50

percent less likely to have breast cancer, when compared with women with the lowest blood levels (25 nmol/l or less). As lead author Cedric Garland elaborated in a press release from the University of California: “The data were very clear, showing that individuals in the group with the lowest blood levels had the highest rates of breast cancer, and the breast cancer rates dropped as the blood levels of vitamin D increased.” (UCalSanDiego, 2/7/2007) Dr. Garland’s team noted that women could achieve a protective blood level (80 nmol/l) by taking two steps: * Consume 2000 IU or vitamin D per day.* Spend about 12 minutes a day in the noontime sun (longer on cloudy days), with 50 percent of their skin

exposed to the sun Vitamin D versus colon cancer The multi-university team’s second meta-analysis, which looked for links between colorectal cancer and vitamin D status, encompassed five studies in which blood was drawn from 1,448 participants (all Caucasian). The volunteers’ blood samples were divided into five equal groups, from the lowest blood levels of vitamin D to the highest. The people with the highest blood levels had half the incidence of colon cancer, compared with those measuring the lowest vitamin D levels. And as lead author Gorham said, “We project a two-thirds reduction in incidence with serum levels of

46 nanograms per milliliter [117 nmol/l], which corresponds to a daily intake of 2,000 IU of vitamin D3.” The meta-analysis included data from the Women's Health Initiative, which found no preventive benefit from low levels of vitamin D intake. However, the new meta-analysis indicates that higher doses can do the trick. How much D do we need? The current recommended daily allowance set by the US government is 400 IU of vitamin D per day: a consumption level that bears no relation to needs or safety concerns, and puts many people at risk. Vitamin D experts like Dr. F. Holick of Boston University – who co-authored both of the new

studies -- believe the evidence shows that the minimum blood level for cancer-prevention and bone-strengthening is 80 nanomoles per liter (nmol/l), and that optimal vitamin D levels range from 115-128 nmol/l. Vitamin D levels below 50 nmol/l may raise the risk of osteoporosis, major cancers, and autoimmune diseases like MS and rheumatoid arthritis. This is why he and others recommended that people consume 1,000 to 2,000 IU of vitamin D daily, which is the amount need to achieve 80 nmol/l. And these researchers say that people 70 years old and older may need more than 100 nmol/l. Yet, a third of the US population has less than 30 nmol/l of vitamin D in their blood during at least part of the year, and the

average level through the four seasons is in the low 60s. If 80 nmol/l is the minimum adequate blood level, then almost all Americans are vitamin D-deficient during at least part of the year. How vitamin D fights cancer Vitamin D appears to help inhibit development of cancer in two ways: * Vitamin D inhibits inappropriate cell division and enhances the anti-cancer actions of immune system chemicals (e.g., tumor necrosis factor, interleukins 1 and 6). * The active hormonal version of vitamin D is produced from circulating vitamin D by cells in organs prone to cancer (e.g., colon, breast, prostate, and skin), which means

that it is able to influence the initiation and growth of cancers in these organs. And vitamin D also helps once a cancer gets a toehold: * Vitamin D reduces blood vessel formation around tumors and inhibits metastasis: actions that become important once cancer develops.* Vitamin D enhances the efficacy of chemotherapy drugs (e.g., doxorubicin) D3 versus D2: Getting more vitamin D, in the right form Wild salmon, wild salmon oil, and cod liver oil are the best food sources of vitamin D by far, and these sources are also extremely low in contaminants like mercury or PCBs. (See our companion article “Wild Salmon Affirmed as

Top Vitamin D Source”.) There are two forms of vitamin D, and only one – vitamin D3 -- is recommended by the researchers, as it is the most biologically active form, and also the form that studies associate with preventive health benefits. Fish contain vitamin D3, but most supplements contain vitamin D2: the form found in plants, whose characteristics make it much less useful to the body and much less effective for preventive health In other works, it takes much less D3 to equal the health effects of a given amount of D2. The distinction between vitamin D2 and vitamin D3 is analogous to the difference between the

short-chain, plant-source omega-3 called ALA -- only 5-15 percent of which the body can convert to the long-chain forms it needs (e.g., EPA and DHA) -- and long chain omega-3s, which are abundant only in fish and zooplankton. Suzi What is a weed? A plant whose virtues have not yet been discovered. health/ http://suziesgoats.wholefoodfarmacy.com/ http://360./suziesgoats

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