Re: Deths talk at recent DAN! conference

[Guest guest]

Hi, .

>

> I know Jill and Rich have studied Deth's work and I wonder if you

can

> help me out. I've watched his presentation at the April DAN!

Conference

> and have a couple of questions:

> a. he talks about how the methionine synthase (MS) enzyme shuts

down

> during oxidative stress and he says it can occur 2 ways

> 1. temporarily when cobalamin is oxidized

> 2. clipping SAMe when the oxidative stress is more

permanent.

>

> He talks about nature doing this. What does he mean ? Does he

mean

> nature is shutting down the enzyme when it sees cobalamin is

oxidized ?

***I think what he means is that it is built into the chemistry (he

likes to call it " nature " ) that when the redox conditions become

oxidizing, for whatever reason, the activity of methionine synthase

is decreased, and the flow from homocysteine to methionine is

therefore decreased, while the flow from homocysteint to

cystathionine and on down the transsulfuration pathway is

increased. The result is that there will me more cysteine supplied

to make glutathione, which is the basis for the antioxidant enzyme

system. Normally, it then combats the state of oxidative stress and

returns the redox potential back to the normal range.

***This is a built-in system to take care of oxidative stress. If

there isn't as much of an oxidative stress problem, then the

homocysteine is converted back to methionine.

>

> b. in a slide he shows the activity of the MS enzyme in the liver,

> cortical and other parts of the brain. In the liver, the

> hydroxycobalamin shows the higher activity, in the brain it is the

MB12

> that shows the higher activity. He then goes on to say that this

means

> the brain has the form of the enzyme w/o the SAMe domain. How

does he

> conclude this ?

***I think he means that the complete enzyme has two ways of being

reset so it can operate again. One is by means of methylcobalamin,

and the other is by means of SAMe. In other to use this second

method, the enzyme must have the part that binds SAMe. If only

hydroxocobalamin is present, then the enzyme must be being reset by

SAMe. On the other hand, if there is plenty of methylcobalamin

present, then the enzyme must be using that to reset itself, and not

SAMe. I think that's what he's saying, but I haven't watched that

one yet. Hard to find time to do all the things I'd like to!

>

> Regards,

>

>

***Rich