CDC/Borrelia burgdorferi

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Hello All,

Attached is an article from the CDC, Division of Vector-borne Infectious

disease. I have waited for several years to see this report published. The CDC

is saying that B. Burgdorferi is an immune-evasive microorganism capable of

causing " acute and CHRONIC neurodegenerative disease " one which invade neural

cells and remains alive in the process. I knew this information back in 1999!

====================

Invasion of human neuronal and glial cells by an infectious strain of Borrelia

burgdorferi.

a.. Livengood JA<about:blank>,

b.. Gilmore RD Jr<about:blank>.

Centers for Disease Control and Prevention, Division of Vector-borne Infectious

Diseases, 3150 Rampart Road, CSU Foothills Campus, Fort , CO 80522, USA.

Human infection by Borrelia burgdorferi, the etiological agent for Lyme disease,

can result in serious acute and late-term disorders including neuroborreliosis,

a degenerative condition of the peripheral and central nervous systems. To

examine the mechanisms involved in the cellular pathogenesis of

neuroborreliosis, we investigated the ability of B. burgdorferi to attach to

and/or invade a panel of human neuroglial and cortical neuronal cells. In all

neural cells tested, we observed B. burgdorferi in association with the cell by

confocal microscopy. Further analysis by differential immunofluorescent staining

of external and internal organisms, and a gentamicin protection assay

demonstrated an intracellular localization of B. burgdorferi. A non-infectious

strain of B. burgdorferi was attenuated in its ability to associate with these

neural cells, suggesting that a specific borrelial factor related to cellular

infectivity was responsible for the association. Cytopathic effects were not

observed following infection of these cell lines with B. burgdorferi, and

internalized spirochetes were found to be viable. Invasion of neural cells by B.

burgdorferi provides a putative mechanism for the organism to avoid the host's

immune response while potentially causing functional damage to neural cells

during infection of the CNS.

PMID: 17045505 [PubMed - as supplied by publisher]