Reduced APC Resistance

[Guest guest]

I was sent to a hematologist for coagulation testing. He told me my

" blood looked very unexciting underneath the microscope " . I felt as

though I should apologize - he took a long time telling me about how

normal all my tests were. He paused and said that he had found one

abnormality called " reduced APC resistance " . He then started talking at

the speed of light and lost me. I have Googled but I cannot make sense

of the search results.

He said to take the 81 mg. of Aspirin per day, but not to worry about it

if I didn't tolerate it. He gave me a requisition for the Factor V

Leiden test, which tests whether this abnormality is genetic or not (I

think, or is it more) and that if I tested positive I'd need to notify

my " first degree relatives " .

There is a strong cardiac history on my father's side; my father had a

heart attack, then years later a debilitating stroke.

I felt very much as though I was wasting his time. Does anyone have any

idea whether this diagnosis has any connection with CFS or whether it is

of any importance at all?

Are there any alternatives to taking Aspirin which my stomach does not

tolerate? How important is it to take the Aspirin?

Thanks to anyone who can help.

Kathy F.

[Guest guest]

Kathy,

I'm not sure if this will be of any help but as far as I know APC

resistance has to do with Thrombosis if I'm correct.

APC means Activated Protein C Wikipedia has the following info:

http://en.wikipedia.org/wiki/Activated_protein_C_resistance

and this website is also reasonably understandable:

http://medinfo.ufl.edu/year2/coag/apc.html

I think the Aspirin you're suppose to take is to prevent this

Thrombosis. Apparently the hematologist didn't think your test

results were that bad otherwise he wouldn't have said 'not to worry

if you can't tolerate it'.

It is an hereditary condition so that's why he wants you to take the

Factor V Leiden test.

Wether or not it is related to CFS I don't know, I do know that I

have a problem with coagulation as well. My laboratory where I have

my test done knows this but they never suggested I should have test

done to determine what causes the strange coagulation.

As soon as they draw blood it clots almost immediately. And I have

such a low blood volume that it takes them forever to get 3 or 4

vials of blood. It literally just drips out. And most of the times

they have to put and IV line in somewhere else to get some more.

I always believed this was CFS/ME related as I heard of more people

who have low blood volume. However I didn't come across Reduced APC

Resistance.

Someone else who can shine a light on this perhaps?

--

Portland, OR

At 7:28 PM -0600 01/11/08, Kathy Froese wrote about

Reduced APC Resistance:

|I was sent to a hematologist for coagulation testing. He told me my

| " blood looked very unexciting underneath the microscope " . I felt as

|though I should apologize - he took a long time telling me about how

|normal all my tests were. He paused and said that he had found one

|abnormality called " reduced APC resistance " . He then started talking at

|the speed of light and lost me. I have Googled but I cannot make sense

|of the search results.

|

|He said to take the 81 mg. of Aspirin per day, but not to worry about it

|if I didn't tolerate it. He gave me a requisition for the Factor V

|Leiden test, which tests whether this abnormality is genetic or not (I

|think, or is it more) and that if I tested positive I'd need to notify

|my " first degree relatives " .

|

|There is a strong cardiac history on my father's side; my father had a

|heart attack, then years later a debilitating stroke.

|

|I felt very much as though I was wasting his time. Does anyone have any

|idea whether this diagnosis has any connection with CFS or whether it is

|of any importance at all?

|

|Are there any alternatives to taking Aspirin which my stomach does not

|tolerate? How important is it to take the Aspirin?

|

|Thanks to anyone who can help.

|

|Kathy F.