Re: Vit. D, allergies, and bad reactions

[Guest guest]

My 25-OH was <7, and I too had a bad reaction to about 200 iu Vit. D.

Felt flu-like, barely had energy to even walk, totally exhausted,

felt depressed, no appetite, had to lay down and sleep, felt

horrible. Then for the next 2-3 days, noticed increased

sinus/allergy symptoms: nose running, watery eyes, congestion. I

have MCS and am always bothered by my wife's hair spray if I am in

the bathroom when she uses it. After the Vit. D, I was in the den,

my wife was in the bedroom (bedroom door shut), in the bathroom (door

also shut), while in the den and not knowing she was using the hair

spray, I suddenly smelled it very strongly just like I do if I am in

the bathroom, but not only did I smell it, I could actually taste it

in my mouth, and I was in the Den!

I know it souds crazy, but it happened. At this point I don't know

if Vit. D is bad or good for me. I know there are others who are low

and do well with supplementing Vit. D. and there are those that

report bad reactions. I have since just started reading the info. on

Vit. D and at this point am confused. Did I just have an immune

reaction which would have gone away if I could tough it out, I don't

know? Is it really bad for me in my particular case, I don't konw?

As usual, there is conflicting information out there. I am not

posting this to discourage or encourage the use of Vit. D. As I

said, I don't know what to believe. But I am posting because there

was someone, I think , who posted and said they had an

increase in allergy symptoms with Vit. D. There is a group that is

against Vit. D and there is a link there to an article that says that

1-25 OH stimulates the TH2 system cytokines. Maybe, and again I

don't know, I'm only sharing this information, this could explain the

increase in allergy symptoms. There was also a person involved in

that protocol that posted, rather proudly, that her allergy symptoms

had greatly increased and she saw this a good sign. The article is:

J Allergy Clin Immunol. 2000 Nov;106(5):981-5. Links

Additive immunosuppressive effects of 1,25-dihydroxyvitamin D3 and

corticosteroids on TH1, but not TH2, responses.Jirapongsananuruk O,

Melamed I, Leung DY.

Division of Pediatric Allergy-Immunology, National Jewish Medical and

Research Center, Denver, and Department of Pediatrics, University of

Colorado Health Science Center, Denver.

BACKGROUND: The biologic role of the vitamin D analogue 1, 25-

dihydroxyvitamin D(3), such as antiinflammatory functions, reduction

of cytokine production by T cells, and immunoglobulin production by B

cells, has been reported. Such immunomodulatory effects may be

potentially useful in dealing with autoimmunity and transplantation.

However, whether this hormone has an additive immunosuppressive

effect when it is used with corticosteroids has not been

investigated, although these agents are commonly used together.

OBJECTIVE: Our purpose was to investigate the additive

immunomodulatory effects of 1,25-dihydroxyvitamin D(3) on lymphocyte

proliferation and cytokine production when used with corticosteroids.

METHODS: To investigate the additive effects of 1, 25-

dihydroxyvitamin D(3) and dexamethasone on suppression of lymphocyte

proliferation, normal PBMCs were cultured in anti-CD3 with or without

different concentrations of dexamethasone (0-10(-7) mol/L) plus or

minus different concentrations of 1, 25-dihydroxyvitamin D(3) (0-10(-

6) mol/L). After 3 days, lymphocyte proliferation was assessed by [(3)

H]-thymidine incorporation. To investigate the additive effects of

1,25-dihydroxyvitamin D(3) and dexamethasone on cytokine production,

PBMCs were cultured for 3 days in the presence of anti-CD3 with or

without 10(-6) mol/L dexamethasone plus or minus 10(-6) mol/L 1,25-

dihydroxyvitamin D(3). IFN-gamma, IL-5, and IL-13 production in

supernatants were measured by ELISA. RESULTS: Our study demonstrated

that, at concentrations of 10(-8), 10(-7), and 10(-6) mol/L, 1,25-

dihydroxyvitamin D(3) significantly decreased lymphocyte

proliferation compared with an ethanol control (P <.05). The IC(50)

for dexamethasone was 4 x 10(-9) mol/L in culture without 1,25-

dihydroxyvitamin D(3.) When 10(-9) mol/L of 1,25-dihydroxyvitamin D

(3) was added to cultures with dexamethasone, IC(50) became 2 x 10(-

9) mol/L. Moreover, when 10(-6), 10(-7), and 10(-8) mol/L of 1,25-

dihydroxyvitamin D(3) were added in culture with dexamethasone, IC

(50) became less than 1 x 10(-9) mol/L. IFN-gamma production in

culture with either dexamethasone or 1,25-dihydroxyvitamin D(3) was

significantly decreased compared with media or ethanol control (P

<.0001). Moreover, when both agents were added in the same culture,

IFN-gamma production was further decreased compared with either agent

alone (P <.05). In contrast, 1,25-dihydroxyvitamin D(3) significantly

(P <. 0001) increased IL-5 and IL-13, whereas dexamethasone

significantly decreased these 2 cytokines (P <.0005). When 1,25-

dihydroxyvitamin D(3) was combined with dexamethasone, IL-5 and IL-13

production was increased compared with dexamethasone alone (P <.001).

CONCLUSIONS: Our results demonstrate that 1,25-dihydroxyvitamin D(3)

has significant additive effects on dexamethasone-mediated inhibition

of lymphocyte proliferation. This hormone also has additive effects

on inhibition of T(H)1 cytokine production when combined with

dexamethasone. However, this hormone upregulates T(H)2 cytokines and

inhibits steroid-mediated suppression of cytokines. These findings

demonstrate the potential use of 1,25-dihydroxyvitamin D(3) as an

immunosuppressive agent when combined with corticosteroids in T(H)1,

but not T(H)2, immune responses.

PMID: 11080724 [PubMed - indexed for MEDLINE]

Pointer

[Guest guest]

Yeah, that's a difficult question to answer. I seem to have strong reactions to

" d " , but I'm

low as well. My doc says it may be due to an overall fat metabolism problem,

but go back

next week to find out more.

I would guess that your symptoms may be a sign that your immune function is

trying to

balance itself, but that's just a guess. Maybe trying 50 iu's for a week, then

slowly working

up? I don't know...

d.

>

> My 25-OH was <7, and I too had a bad reaction to about 200 iu Vit. D.

> Felt flu-like, barely had energy to even walk, totally exhausted,

> felt depressed, no appetite, had to lay down and sleep, felt

> horrible. Then for the next 2-3 days, noticed increased

> sinus/allergy symptoms: nose running, watery eyes, congestion. I

> have MCS and am always bothered by my wife's hair spray if I am in

> the bathroom when she uses it. After the Vit. D, I was in the den,

> my wife was in the bedroom (bedroom door shut), in the bathroom (door

> also shut), while in the den and not knowing she was using the hair

> spray, I suddenly smelled it very strongly just like I do if I am in

> the bathroom, but not only did I smell it, I could actually taste it

> in my mouth, and I was in the Den!

> I know it souds crazy, but it happened. At this point I don't know

> if Vit. D is bad or good for me. I know there are others who are low

> and do well with supplementing Vit. D. and there are those that

> report bad reactions. I have since just started reading the info. on

> Vit. D and at this point am confused. Did I just have an immune

> reaction which would have gone away if I could tough it out, I don't

> know? Is it really bad for me in my particular case, I don't konw?

> As usual, there is conflicting information out there. I am not

> posting this to discourage or encourage the use of Vit. D. As I

> said, I don't know what to believe. But I am posting because there

> was someone, I think , who posted and said they had an

> increase in allergy symptoms with Vit. D. There is a group that is

> against Vit. D and there is a link there to an article that says that

> 1-25 OH stimulates the TH2 system cytokines. Maybe, and again I

> don't know, I'm only sharing this information, this could explain the

> increase in allergy symptoms. There was also a person involved in

> that protocol that posted, rather proudly, that her allergy symptoms

> had greatly increased and she saw this a good sign. The article is:

>

> J Allergy Clin Immunol. 2000 Nov;106(5):981-5. Links

> Additive immunosuppressive effects of 1,25-dihydroxyvitamin D3 and

> corticosteroids on TH1, but not TH2, responses.Jirapongsananuruk O,

> Melamed I, Leung DY.

> Division of Pediatric Allergy-Immunology, National Jewish Medical and

> Research Center, Denver, and Department of Pediatrics, University of

> Colorado Health Science Center, Denver.

>

> BACKGROUND: The biologic role of the vitamin D analogue 1, 25-

> dihydroxyvitamin D(3), such as antiinflammatory functions, reduction

> of cytokine production by T cells, and immunoglobulin production by B

> cells, has been reported. Such immunomodulatory effects may be

> potentially useful in dealing with autoimmunity and transplantation.

> However, whether this hormone has an additive immunosuppressive

> effect when it is used with corticosteroids has not been

> investigated, although these agents are commonly used together.

> OBJECTIVE: Our purpose was to investigate the additive

> immunomodulatory effects of 1,25-dihydroxyvitamin D(3) on lymphocyte

> proliferation and cytokine production when used with corticosteroids.

> METHODS: To investigate the additive effects of 1, 25-

> dihydroxyvitamin D(3) and dexamethasone on suppression of lymphocyte

> proliferation, normal PBMCs were cultured in anti-CD3 with or without

> different concentrations of dexamethasone (0-10(-7) mol/L) plus or

> minus different concentrations of 1, 25-dihydroxyvitamin D(3) (0-10(-

> 6) mol/L). After 3 days, lymphocyte proliferation was assessed by [(3)

> H]-thymidine incorporation. To investigate the additive effects of

> 1,25-dihydroxyvitamin D(3) and dexamethasone on cytokine production,

> PBMCs were cultured for 3 days in the presence of anti-CD3 with or

> without 10(-6) mol/L dexamethasone plus or minus 10(-6) mol/L 1,25-

> dihydroxyvitamin D(3). IFN-gamma, IL-5, and IL-13 production in

> supernatants were measured by ELISA. RESULTS: Our study demonstrated

> that, at concentrations of 10(-8), 10(-7), and 10(-6) mol/L, 1,25-

> dihydroxyvitamin D(3) significantly decreased lymphocyte

> proliferation compared with an ethanol control (P <.05). The IC(50)

> for dexamethasone was 4 x 10(-9) mol/L in culture without 1,25-

> dihydroxyvitamin D(3.) When 10(-9) mol/L of 1,25-dihydroxyvitamin D

> (3) was added to cultures with dexamethasone, IC(50) became 2 x 10(-

> 9) mol/L. Moreover, when 10(-6), 10(-7), and 10(-8) mol/L of 1,25-

> dihydroxyvitamin D(3) were added in culture with dexamethasone, IC

> (50) became less than 1 x 10(-9) mol/L. IFN-gamma production in

> culture with either dexamethasone or 1,25-dihydroxyvitamin D(3) was

> significantly decreased compared with media or ethanol control (P

> <.0001). Moreover, when both agents were added in the same culture,

> IFN-gamma production was further decreased compared with either agent

> alone (P <.05). In contrast, 1,25-dihydroxyvitamin D(3) significantly

> (P <. 0001) increased IL-5 and IL-13, whereas dexamethasone

> significantly decreased these 2 cytokines (P <.0005). When 1,25-

> dihydroxyvitamin D(3) was combined with dexamethasone, IL-5 and IL-13

> production was increased compared with dexamethasone alone (P <.001).

> CONCLUSIONS: Our results demonstrate that 1,25-dihydroxyvitamin D(3)

> has significant additive effects on dexamethasone-mediated inhibition

> of lymphocyte proliferation. This hormone also has additive effects

> on inhibition of T(H)1 cytokine production when combined with

> dexamethasone. However, this hormone upregulates T(H)2 cytokines and

> inhibits steroid-mediated suppression of cytokines. These findings

> demonstrate the potential use of 1,25-dihydroxyvitamin D(3) as an

> immunosuppressive agent when combined with corticosteroids in T(H)1,

> but not T(H)2, immune responses.

>

> PMID: 11080724 [PubMed - indexed for MEDLINE]

>

> Pointer

>

[Guest guest]

Hi!

This is interesting thanks for sharing.

I also have had bad reactions to vitamin D. I was low/normal in tests

and took weekly single high dose over a couple months.

Im confused about whether vitamin D supplementation is good for people

with CFS/MCS. They seem to have increased my food allergies.

[Guest guest]

There's actually some evidence from a few studies that 1,25(OH)2D can

make allergies worse. This is why it's important to increase your

vitamin D levels slowly, because if you have low levels, you are more

likely to produce 1,25(OH)2D in response to supplementation. And as I

previously have mentioned, taking extra calcium should suppress 1,25(OH)

2D levels, so maybe that might offset the effect of vitamin D

supplementation.

Then again, the effect of vitamin D supplementation on allergies have

barely been studied, so stay tuned. - Mark

> This is interesting thanks for sharing.

>

> I also have had bad reactions to vitamin D. I was low/normal in tests

> and took weekly single high dose over a couple months.

>

> Im confused about whether vitamin D supplementation is good for people

> with CFS/MCS. They seem to have increased my food allergies.

>

[Guest guest]

Mark- Does calcium lower the actual level of D (the purpose of taking a D

supplement would be to raise the level, right?) or does it only offset the

negative effects felt due to the D rising? Les

Re: Vit. D, allergies, and bad reactions

There's actually some evidence from a few studies that 1,25(OH)2D can

make allergies worse. This is why it's important to increase your

vitamin D levels slowly, because if you have low levels, you are more

likely to produce 1,25(OH)2D in response to supplementation. And as I

previously have mentioned, taking extra calcium should suppress 1,25(OH)

2D levels, so maybe that might offset the effect of vitamin D

supplementation.

Then again, the effect of vitamin D supplementation on allergies have

barely been studied, so stay tuned. - Mark

> This is interesting thanks for sharing.

>

> I also have had bad reactions to vitamin D. I was low/normal in tests

> and took weekly single high dose over a couple months.

>

> Im confused about whether vitamin D supplementation is good for people

> with CFS/MCS. They seem to have increased my food allergies.

>

[Guest guest]

Calcium supplementation can lower serum 1,25(OH)2D (and may increase

25(OH)D, as less is being converted to 1,25(OH)2D). I'm guessing

that negative reactions from taking vitamin D, are due to increases

in serum 1,25(OH)2D (not 25(OH)D). So by taking calcium, maybe one

can reduce 1,25(OH)2D levels enough to avoid that effect.

It's good to take vitamin D with calcium anyway, because a lot of

studies show that vitamin D by itself is not as useful. - Mark

> > This is interesting thanks for sharing.

> >

> > I also have had bad reactions to vitamin D. I was low/normal in

tests

> > and took weekly single high dose over a couple months.

> >

> > Im confused about whether vitamin D supplementation is good for

people

> > with CFS/MCS. They seem to have increased my food allergies.

> >

>

>

>

>

>

>