Re: GABA failed quackery nonsense

[Guest guest]

Just thought I'd add the comment that Yasko says that GABA that is not

manufactured correctly can end up acting in the body as if it's glutamate

instead of GABA, I believe because they are very similar in structure. I

don't have any research or info to back this up, though.

I took a GABA product that I bought at Whole Foods and I definitely did

not feel very good on it (I am sensitive to excitotoxins). I've been using

only the GABA Yasko sells in her store since and it's been working very

well for me.

Amy

On Thu, Jun 5, 2008 at 7:34 PM, lmonrovia <lmonrovia@...> wrote:

> Hi

>

> Yr comment about GABA caught my attention. Do you have any sources on

> this, or is it an observation based on a lot of anecdotal evidence?

>

> I take GABA as part of Yasko's protocol. Couldn't tell you if it makes

> one iota of difference one way or the other... although overall the

> program is helping.

>

> But I'd be interested to read more about this.

> L.

> > Hi, CS.

> >

> Research and consider experimenting with products that lower brain

> glutamate excitoxicity and increase gaba(but NOT the supplement GABA,

> because it's failed > quackery nonsense for dealing with stuff like

> this), >

> >

> > bhammanuk@ wrote:

> >

>

>

>

[Guest guest]

Hi L. and others,

This caught my eye. I also am taking GABA as part of the Yasko

protocol. I'm taking 1500mg daily, on an empty stomach. It's

definitely doing *something* in my system, as approx. 30 minutes after

taking it I get a stinging sensation all over my skin, which then

fades away. I know it's the GABA, because when I first noticed the

effect I experimented with which supplements I was taking in order to

narrow it down.

I couldn't tell you biochemically speaking what the GABA is doing, or

triggering, in my system. But I can tell you that after years of

trying supplements that appeared to have no effect whatsoever, it was

interesting to find one that was actually affecting my system.

Marcia on

in Salem, Massachusetts

> >

>

[Guest guest]

I tried GABA for anxiety about ten years ago and had trouble breathing.

Never again.

Pwr2Heal wrote:

> Just thought I'd add the comment that Yasko says that GABA that is not

> manufactured correctly can end up acting in the body as if it's glutamate

> instead of GABA, I believe because they are very similar in structure. I

> don't have any research or info to back this up, though.

>

> I took a GABA product that I bought at Whole Foods and I definitely did

> not feel very good on it (I am sensitive to excitotoxins). I've been using

> only the GABA Yasko sells in her store since and it's been working very

> well for me.

>

> Amy

>

> On Thu, Jun 5, 2008 at 7:34 PM, lmonrovia <lmonrovia@...> wrote:

>

>

>> Hi

>>

>> Yr comment about GABA caught my attention. Do you have any sources on

>> this, or is it an observation based on a lot of anecdotal evidence?

>>

>> I take GABA as part of Yasko's protocol. Couldn't tell you if it makes

>> one iota of difference one way or the other... although overall the

>> program is helping.

>>

>> But I'd be interested to read more about this.

>> L.

>>

>>> Hi, CS.

>>>

>>>

>> Research and consider experimenting with products that lower brain

>> glutamate excitoxicity and increase gaba(but NOT the supplement GABA,

>> because it's failed > quackery nonsense for dealing with stuff like

>> this), >

>>

>>> bhammanuk@ wrote:

>>>

>>>

>>

>>

>>

>

>

>

[Guest guest]

Hi, Marcia and L..

My comments are below with an *** next to them.

<mmorrison@...> wrote:

>

> Hi L. and others,

>

> This caught my eye. I also am taking GABA as part of the Yasko

> protocol. I'm taking 1500mg daily, on an empty stomach. It's

> definitely doing *something* in my system, as approx. 30 minutes after

> taking it I get a stinging sensation all over my skin, which then

> fades away.

***Sounds like you're body may be turning the GABA into glutamate,

thus increasing glutamate excitotoxicity. " Something " happening other

than the intended result is not impressive I suggest. No intended

result, no pass as an effective treatment. Some call this reality

testing.

I know it's the GABA, because when I first noticed the

> effect I experimented with which supplements I was taking in order to

> narrow it down.

" lmonrovia " <lmonrovia@>

> wrote:

> >

> > Hi

> >

> > Yr comment about GABA caught my attention. Do you have any sources on

> > this, or is it an observation based on a lot of anecdotal evidence?

***This statement really belongs the other way around. Do docs

promoting the use of this stuff have peer reviewed and controlled

studies that say supplemention with gaba reduces glutamate

excitotoxicity let alone show it as able to reach our brains, which I

suggest it does not through supplementation.

***And I suggest the problem with glutamate excitotoxicity in ME/CFS

is not so much lack of gaba, but rather the issue of the body or brain

producing so much glutamate at the expense of gaba production. There

seems to be all the stuff available for making plenty of gaba in our

bodies, but it doesn't appear to be doing this.

> >

> > I take GABA as part of Yasko's protocol. Couldn't tell you if it

makes

> > one iota of difference one way or the other...

***Lack of producing the intended result as I stated above is a big

hint and a damning affront to anyone claiming a supplements

effectiveness. And it's hard for people, and sick people at that, to

admit they've been ripped off or have at least had their precious

financial and energetic resources unceremoniously squandered away

based on less than rigorous claims.

***

[Guest guest]

I've tried 2 types, 1 was holistic heal/Dr Amy's. Both gave awful

results in minute quantities, too awful to try and gauge which was

worse. My understanding from wikipedia is that there are 2 different

sorts of gaba receptor mechanisms. Gaba works well for my gut, so

possible that mechaism functions ok, whilst in the brain experience

was torture. Something to do with chloride ion channels I think.

Here's aclip from Wiki

http://en.wikipedia.org/wiki/GABA

Whether GABA is excitatory or inhibitory depends on the direction

(into or out of the cell) and magnitude of the ionic currents

controlled by the GABAA receptor. When net positive ionic current is

directed into the cell, GABA is excitatory, when the net positive

current is directed out of the cell, GABA is inhibitory. A

developmental switch in the molecular machinery controlling the

polarity of this current is responsible for the changes in the

functional role of GABA between the neonatal and adult stages.

> > >

> >

> >

> >

>

>

>

[Guest guest]

Oops, I forgot the receptor mechanism bit:

http://en.wikipedia.org/wiki/GABA

Three general classes of GABA receptor are known: GABAA and GABAC

ionotropic receptors, which are ion channels themselves, and GABAB

metabotropic receptors, which are G protein-coupled receptors that

open ion channels via intermediaries (G proteins).

J

>

> I've tried 2 types, 1 was holistic heal/Dr Amy's. Both gave awful

> results in minute quantities, too awful to try and gauge which was

> worse. My understanding from wikipedia is that there are 2

different

> sorts of gaba receptor mechanisms. Gaba works well for my gut, so

> possible that mechaism functions ok, whilst in the brain experience

> was torture. Something to do with chloride ion channels I think.

>

> Here's aclip from Wiki

> http://en.wikipedia.org/wiki/GABA

> Whether GABA is excitatory or inhibitory depends on the direction

> (into or out of the cell) and magnitude of the ionic currents

> controlled by the GABAA receptor. When net positive ionic current

is

> directed into the cell, GABA is excitatory, when the net positive

> current is directed out of the cell, GABA is inhibitory. A

> developmental switch in the molecular machinery controlling the

> polarity of this current is responsible for the changes in the

> functional role of GABA between the neonatal and adult stages.

>

>