[Mark] Can ARBs worsen CFS symptoms?

[Guest guest]

Mark,

Always good to hear from you. Could you define these terms for folks

like me who forget what they mean, or maybe never knew.

RAS agonists (eg angiotensin mimetics), or adrenergic agonists. It

also suggests that there will be a positive link between the use of

adrenergic- and RAS-blocking drugs and CFS incidence, and a negative

link between adrenergic agonist use and CFS.

Thanks,

a Carnes

[Guest guest]

Hi - I took off early from work in order to go visit a medical

library, where I could access the full text of the article which I

posted. The article is in a medical hypotheses journal, which

sometimes has very outlandish theories. But at least I would expect

that the articles would not have major errors. However, I think it

does. For example, the guy claims that there is low RAS activation

in CFS, and that in support of this, he references the old study that

showed that ACE levels was a marker for CFS. He also mentions the

study that showed that Gulf War veterans with the I allele of the ACE

gene are less likely to develop CFS. But he claims that the I allele

is the " high-level expression " . However, the exact opposite is true,

i.e. the I allele is the low-level ACE expression. And the study

which showed that ACE levels were a marker for CFS, showed that high

ACE levels were present, not low. Everything that I've read

elsewhere, shows that high ACE levels implies increased RAS

activation. So I have no idea what this guy is a thinking.

I suspect this is yet another example of the poor review process that

is present in many journals. It used to amaze me the first few times

that I encountered such errors, but now it no longer does.

Sorry that I posted this link before I had chance to actually read

the full text of the article. - Mark

>

> Mark,

> Always good to hear from you. Could you define these terms for folks

> like me who forget what they mean, or maybe never knew.

>

> RAS agonists (eg angiotensin mimetics), or adrenergic agonists. It

> also suggests that there will be a positive link between the use of

> adrenergic- and RAS-blocking drugs and CFS incidence, and a negative

> link between adrenergic agonist use and CFS.

>

>

> Thanks,

> a Carnes

>