Genetic marker study

[Guest guest]

I'm sure identifying genetic markers for autism is good idea but

the question I have is if mercury in vaccines is indeed the cause

of ASD, ADD, ADHD, etc. does it really matter? It would be like

putting 10 males over 40 on a high saturated fat, high glycemic

diet e.g. the Krispy Kreme burger for every meal, and no exercise

for 5 years and spend millions of dollars trying to figure out why 3

of them developed heart disease and the others didn't. It doesn't

matter. They shouldn't have been eating the crap in the first

place. Same with the mercury. The kids shouldn't receiving it from

the get-go regardles of their genetic pre-disposition.

> >

> > We are looking for genetic markers in the lymphocytes of DD kids,

> their sibs and parents. These markers are already present in fetal

> cells at birth but the initial studies, designed to find a

relevant

> " marker haplotype " won't be done on cord blood.

> >

> > HHF

>

[Guest guest]

What is common sense and what is contrary to self-interst are often mutually exclusive.

They certainly are in this case.

Re: Genetic Marker Study

I'm sure identifying genetic markers for autism is good idea but the question I have is if mercury in vaccines is indeed the cause of ASD, ADD, ADHD, etc. does it really matter? It would be like putting 10 males over 40 on a high saturated fat, high glycemic diet e.g. the Krispy Kreme burger for every meal, and no exercise for 5 years and spend millions of dollars trying to figure out why 3 of them developed heart disease and the others didn't. It doesn't matter. They shouldn't have been eating the crap in the first place. Same with the mercury. The kids shouldn't receiving it from the get-go regardles of their genetic pre-disposition.> >> > We are looking for genetic markers in the lymphocytes of DD kids,> their sibs and parents. These markers are already present in fetal> cells at birth but the initial studies, designed to find a relevant> "marker haplotype" won't be done on cord blood.> > > > HHF>

[Guest guest]

More grist for the mill, are they barking up the right tree however?

R

[Moderator: The absence of statistical confidence intervals, namely they looked

at 1467 markers and found that a group of 34 people could be classified by

looking at 9 of these random 1467 markers, leaves me a little concerned. If I

get time today, I will calculate the probability of this being random]

Chronic fatigue syndrome (CFS) is a clinically defined condition characterized

by long-lasting disabling fatigue. Because of the

unknown mechanism underlying this syndrome, there still is no specific biomarker

for objective assessment of the pathological fatigue.

We have compared gene expression profiles in peripheral blood between 11

drug-free patients with CFS and age- and sexmatched

healthy subjects using a custom microarray carrying complementary DNA probes for

1,467 stress-responsive genes.We

identified 12 genes whose mRNA levels were changed significantly in CFS

patients. Of these 12 genes, quantitative real-time PCR

validated the changes in 9 genes encoding granzyme in activated T or natural

killer cells (GZMA), energy regulators (ATP5J2,

COX5B, and DBI), proteasome subunits (PSMA3 and PSMA4), putative protein kinase

c inhibitor (HINT ), GTPase (ARHC), and signal

transducers and activators of transcription 5A (STAT5A). Next,we performed the

same microarray analysis on 3 additional CFS patients

and 20 other patients with the chief complaint of long-lasting fatigue related

to other disorders (non-CFS patients) and

found that the relative mRNA expression of 9 genes classified 79% (11/14) of CFS

and 85% (17/20) of the non-CFS patients. Finally,

real-time PCR measurements of the levels of the 9 involved mRNAs were done in

another group of 18 CFS and 12 non-CFS patients.

The expression pattern correctly classified 94% (17/18) of CFS and 92% (11/12)

of non-CFS patients. Our results suggest that

the defined gene cluster (9 genes) may be useful for detecting pathological

responses in CFS patients and for differential diagnosis

of this syndrome.

From http://www.molmed.org/content/2008/9_10_08/599-607.Saiki.00059.PDF