To a re: glutathione and fluoroquinolone damage

[Guest guest]

Hi, a.

I think you have a big BINGO! here. I've been searching the medical

literature today to see what's known about the damage mechanism of

the fluoroquinolones, and there are some papers that show that these

antibiotics produce reactive oxygen species and oxidative stress, and

that they deplete good old glutathione! This appears to be the

damage mechanism in the tendons, according to one paper (PMID:

14569066). Another paper shows that this is the mechanism that

fluoroquinolones use to kill bacteria, also (PMID: 16495256).

There's also a study in rats showing that this same mechanism

produces damage in the liver and the brain. So glutathione looks

like a promising treatment for fluoroquinolone damage. And you've

cited a case in which IV glutathione appears to have helped. I gather

from the article that the guy is still getting the IV glutathione

treatments.

Going to bowel tolerance on vitamin C might do the trick for you, but

you might have to do it forever if you don't lift the methylation

cycle block, which seems to be what keeps glutathione from coming up

to normal in CFS in many or most cases. I know that you haven't been

very enamored with my methylation cycle block hypothesis in the past,

but maybe it's time to give it another look.

I really hope this pays off for you, a. You've suffered way too

long!

Rich

>

> Rich and all,

> Wow, today is looking to be a lightbulb moment day. I think things

> are beginning to come together for me in terms of how to treat my

> case.

>

> I have ongoing damage from quinolone antibiotics. Today I saw an

> article by Dr. Jay Cohen suggesting that glutathione infusions are

> turning out to be THE solution for this damage.

>

>

http://www.medicationsense.com/articles/jan_dec_08/toxicity070508.html

>

> Now I see that proper dosing of vitamin C is a good way to increase

> glutathione. (Of course, ImmunoPro also helps.)

>

> So I think I am seeing a direction to head in. Others might want to

> be cautious about ever taking quinolone antibiotics because we cfs

> patients are generally all low in glutathione. If you think in

> reverse this MIGHT mean we are all likely to get quinolone toxicity

> damage.

>

> a Carnes