Re: Some pain meds. now increasing my muscle pain

[Guest guest]

Yes I have.

I'm a member of the ME association in the UK and have been in contact

with dr. Shepherd medical adviser of the association. Dr. Shepherd is

working on a paper and collecting anecdotal reports of people with ME

and morphine sensitivity. He has found instances where someone with ME/

CFS appears to have some form of morphine resistance/sensitivity.(not

the same as 'tolerance')

He will be reporting back to co-cure and ME magazines once he had the

opportunity to speak this trough with pharmacology colleagues.

My personal problem with Morphine and other opioids is that they don't

lessen my pain but instead give me muscle spams and pains. I know it's

the morphine because the pain starts about 30 minutes after I take

medication if it's a direct release and later if it's slow release

version. Still I keep taking them because the offer me sleep. Since I

switched to slow release I wake up later in pain. They immediately

release I was in pain for the first hour and am than able to sleep for

a great deal. And besides providing me with sleep they make my life

bearable.

The Detox Genomic profile I took also showed why my body reacted this

way.

[links]

* dr Shepherd's blog message and explanation: Wanted – information on

possible morphine resistance in ME/CFS

http://meassocnews.blogspot.com/2006/06/wanted-information-on-possible.html

* Opioid-induced hyperalgesia

http://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia

* Opioid-induced hyperalgesia: pathophysiology and clinical

implications.

http://www.ncbi.nlm.nih.gov/pubmed/18717507

* Opioid-Induced Hyperalgesia

http://www.medscape.com/viewarticle/562216_4

[/links]

--

Portland, OR

On Dec 9, 2008, at 11:38 AM, sb2boys wrote:

> Has anyone else experienced this?

>

> Thank you!

>

> Sue

[Guest guest]

sb2boys wrote:

>

> Has anyone else experienced this?

If the drug upregulates the NO/ONOO- cycle, it wouldn't surprise me.

Jeri <teewinot13@...>

[Guest guest]

>

> Has anyone else experienced this?

>

> Thank you!

>

> Sue

>

I experienced a rapid exponential (and permanent )

increase in pain 4 years ago after trying duragesic patches for 6 days.

It totally disabled me, tripled my " normal " pain levels, and added the

symptom of chronic fatigue (i can " work " and by work i mean i was

literally in a desk job call center, for an hour to 2 tops then i

would have to crash due to pain and fatigue)

it is almost as if I have a new disease the transformation was so radical.

I recently ran across the term opioid induced hyperalgesia

(http://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia)

and it is the closest explanation I have to what happened to me, but

my doctors left me hanging, and I have not had any improvement the

last 4 years.

I took some info to my pain management doc, and left it with the

nurse, if he has no suggestions of referrals I am going to start

looking for a new doctor.

[Guest guest]

> [links]

> * dr Shepherd's blog message and explanation: Wanted – information on

> possible morphine resistance in ME/CFS

>

http://meassocnews.blogspot.com/2006/06/wanted-information-on-possible.html

>

> * Opioid-induced hyperalgesia

> http://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia

>

> * Opioid-induced hyperalgesia: pathophysiology and clinical

> implications.

> http://www.ncbi.nlm.nih.gov/pubmed/18717507

>

> * Opioid-Induced Hyperalgesia

> http://www.medscape.com/viewarticle/562216_4

> [/links]

>

> --

>

> Portland, OR

>

>

>

>

>

> On Dec 9, 2008, at 11:38 AM, sb2boys wrote:

>

> > Has anyone else experienced this?

> >

> > Thank you!

> >

> > Sue

>

Man I guess I should read more than just the OP thanks for the info I

have been stonewalled by uncaring doctors for the past 4 years

[Guest guest]

Also interesting to read is this recent article:

http://pain-topics.org/pdf/Compton-OIH-Paradox.pdf

- Mark

[Guest guest]

I tried Morphine and Methodone 2 times. Both times just taking one

pill. I hadn't been taking it. Within 20 minutes, I had increased

muscle pain. I used to be able to take Maxalt to help with my

migraines; but now Maxalt also increases my pain.

I'm concerned about the future and muscle pain management. Also, what

if I get cancer or something. There's a lot of cancer in my family.

How will that pain be managed??

Sue

> I experienced a rapid exponential (and permanent )

> increase in pain 4 years ago after trying duragesic patches for 6 days.

>

> It totally disabled me, tripled my " normal " pain levels, and added the

> symptom of chronic fatigue (i can " work " and by work i mean i was

> literally in a desk job call center, for an hour to 2 tops then i

> would have to crash due to pain and fatigue)

>

> it is almost as if I have a new disease the transformation was so

radical.

>

> I recently ran across the term opioid induced hyperalgesia

> (http://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia)

> and it is the closest explanation I have to what happened to me, but

> my doctors left me hanging, and I have not had any improvement the

> last 4 years.

> I took some info to my pain management doc, and left it with the

> nurse, if he has no suggestions of referrals I am going to start

> looking for a new doctor.

>

[Guest guest]

>

> I tried Morphine and Methodone 2 times. Both times just taking one

> pill. I hadn't been taking it. Within 20 minutes, I had increased

> muscle pain. I used to be able to take Maxalt to help with my

> migraines; but now Maxalt also increases my pain.

>

> I'm concerned about the future and muscle pain management. Also, what

> if I get cancer or something. There's a lot of cancer in my family.

> How will that pain be managed??

>

> Sue

>

>I know, I have suffered pretty bad the past 4 years since the

medication made me worse, and the doctors have done slim to none about

it. I honsetly think I would have a better chance at getting the

doctor to loan me a hundred grand than to give me pain medications

that work.

sorry but 10-15% relief on average doesn't cut it and I spend most of

my time in bed against their orders but I am so tired and in pain its

all I feel like doing. It has taken 2 or more years but I am on 6,

10mg hydrocodone a day, and in ways I know its not that much, but in

ways I know its a lot, and I am just 33 and a half so I have wondered

what I would do if I did get cancer or something else, they would turn

on the faucets from the drip I get now but would it be enough?

But I wouldn't call my life now really living.

[Guest guest]

i can relate to having pain medications only making my pain worse and also

having other negative side effects. i have had this problem with numerous

medications. i'm not sure why, but even medications that i could tolerate and

were helpful in the past i now don't seem to be able to tolerate even small

doses and the negative effects are overwhelming.

my experience with CFS and pain has been especially rough over the past 1 1/2

years. it seems that more of my body's systems have gone down(most

significantly my GI system) lately. most of the docs i have seen can not

explain what is happening, and it seems as though my body reacts strangely to

procedures, treatments, and medications. it's a troubling and frustrating cycle

to be in. i wish i had some answers, but can only relate to your situation.

i'm continually learning to trust my body's signals and reactions and not

forcing myself to continue with doctors' recommendations when they end up being

more harmful than helpful.

being on disability and unable to work, i do the best i can with treatments, but

am limited both financially and energy wise in what i can pursue. if i had more

resources, i would definitely go along a more alternative/holistic route(as

opposed to traditional medicine which isn't serving me well at the moment)

my hope for the new year is continued research and discoveries in to the causes

and treatments of this complicated and devastating illness.

anne

___________________________________________________________

Anne Lindskog alindskog@...

[Guest guest]

Oh and an update of sorts, after giving my doctor some of the

information to his NP over 3 months ago when I finally had my

appointment the other day he looked at the info the first time.

He said he didnt know anything about it, and zeroed in on only 2

portions of the text I gave him, something about ketamine patches or

cream (i cant remember which) and since my whole body hurts would be

little more than band aid. And of course the 1 sentence in the whole

skew of pages that mentions discontinuing medications.

Here's the thing the only med I have had issue with is duragesic, I

was afraid of methadone, but after waiting a month I tried it, and

like before nothing, good or bad. And the hydrocodone helps, but its

very weak as I am taking more than 6 times my old dosage before the

duragesic incident at the end of 04. I also had no problem with the 15

mg morphine I was prescribed several months ago, even at 4 to 5 times

the rxed dosage, problem is none of them put a huge dent in the pain,

but they do help some.

I was planning on firing the guy but he beat me to the puncg asking me

if I wanted him to continue to prescribe, or my regular doctor , I

said I dont care, so he dumped me back on her.

I now need to see if I can find a doctro who is willing to do some

digging into this to try and get me better, (or give me better pain

meds, as he agai nrefused to up my dose, or switch me back to the

morphine which I had no problems with but he is paranoid about it

being more " addictive "

Not knocking cancer patients, but why is is ok to ease the suffering

of the dying, but to do little or nothing for the living, other than

tell them to grin and bear it.

Anyway I have an appointment tomorrow with the chiropractor in their

office so I am going to also request my records to hopefully take to a

more investigative doctor whi wishes to spend the time to at least

figure some of this out.

Any suggestions?