Post Exertional Fatigue Information

[Guest guest]

This is from the about.com fibromyalgia and cfs site

Title: Misplaced Enzyme Blamed for Post Exercise Fatigue

The information is from the scientists at the Medical

Institute

" Researchers say an enzyme called neuronal nitric oxide synthase

(nNOS) isn't where it should be, which is in the membrane surrounding

your muscles. The effect of this missing enzyme is that the blood

vessels feeding active muscles don't relax like they should. In

animal trials, this causes fatigue after mild levels of exertion.

Also in those animal trials, a Viagra-like drug helped regulate

nitric oxide activity and allowed for much more physical activity.

Researchers say, however, that Viagra is too short lasting to be

considered a treatment for people with lowered exercise tolerance.

Longer acting drugs in the same class (PDE inhibitors) currently

being used experimentaly and could be considered for clinical trials. "

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The clinical trials are being considered because this is also good

for muscular distrophy and they are concerned about long term use

accelerating the muscle damage that comes with this condition. This

would not be a concern with CFS, however, so I should think that we

could be using this right now. Anyone know how find out which drug

this would be?

bonnieb