Recent PubMed articles

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" Following two microarray studies, we reported the differential

expression of 88 human genes in patients with CFS; 85 of these genes

were upregulated and 3 were downregulated. The top functional

categories of these 88 genes were hematologic disease and function,

immunologic disease and function, cancer, cell death, immune

response, and infection. Clustering of quantitative polymerase chain

reaction data from CFS/ME patients revealed seven subtypes with

distinct differences in Short Form (SF)-36 scores, clinical

phenotypes, and severity. Gene signatures in each subtype implicate

five human genes as possible targets for specific therapy " PMID:

19007540

" Qigong's positive effects indicate that it represents a potentially

safe method of treatment for chronic fatigued patients. However, we

cannot completely discount the possible influence of placebo effects "

PMID: 18955297

" I suggest that patients with CFS have a reduced ability to increase

mitochondrial energy production when exertion requires it, with fewer

mitochondria that are each more efficient, and hence nearer to their

maximum energy output, than normal. A range of indirect evidence

suggests that the renin-angiotensin system stimulates mitochondrial

responsiveness and reduces mitochondrial efficiency: chronic under-

stimulation of this system could contribute to CFS aetiology. If

correct, this means that CFS can be successfully treated with RAS

agonists (eg angiotensin mimetics), or adrenergic agonists. It also

suggests that there will be a positive link between the use of

adrenergic- and RAS-blocking drugs and CFS incidence, and a negative

link between adrenergic agonist use and CFS. "

PMID: 18684570

" The results support the view that a weakened tight junction barrier

with subsequent gut-derived inflammation is a novel pathway in CFS

and that it is a new target for drug development in CFS. Meanwhile,

CFS patients with leaky gut can be treated with specific NAIOSs and a

leaky gut diet. " PMID: 19112401

" In these adult patients with FM, both doses of milnacipran (100 and

200 mg/d) were associated with significant improvements in pain and

other symptoms. " PMID: 19108787

" RESULTS: MR-VBM and MR-DTI demonstrated a striking pattern of

changes in brain morphology in patients with FMS. Both thalami, the

thalamocortical tracts, and both insular regions showed significant

decreases in FA. In contrast, increases in FA and decreases in gray

matter volume were seen in the postcentral gyri, amygdalae,

hippocampi, superior frontal gyri, and anterior cingulate gyri.

Increased pain intensity scores were correlated with changes in MR-

DTI measurements in the right superior frontal gyrus. Increased

fatigue was correlated with changes in the left superior frontal and

left anterior cingulate gyrus, and self-perceived physical impairment

was correlated with changes in the left postcentral gyrus. Higher

intensity scores for stress symptoms were correlated negatively with

diffusivity in the thalamus and FA in the left insular cortex. "

PMID: 19035484

" Neither Reiki nor touch improved the symptoms of fibromyalgia.

Energy medicine modalities such as Reiki should be rigorously studied

before being recommended to patients with chronic pain symptoms. "

PMID: 18991519

" CONCLUSION: Results suggest that a 6-week traditional exercise

program with supplementary whole-body vibration safely reduces pain

and fatigue, whereas exercise alone fails to induce improvements "

PMID: 18990045

" A significant correlation was evident between serum NO level and

pain. Additionally, the correlation between glutathione level and

morning stiffness was found to be significant. " PMID: 18853166

" Duloxetine 60 mg/day and 120 mg/day has proven to be beneficial in

the treatment of FMS symptoms. " PMID: 18830399

" Positive outcomes were reported for pain, health-status and tender

point count. There is strong evidence for the use of hydrotherapy in

the management of FMS. " PMID: 18751709

" CONCLUSION: Our study revealed that participation in an online

support group had the same profound effect on lurkers' self-reported

feelings of being empowered in several areas as it had on posters.

Apparently, reading in itself is sufficient to profit from

participation in an online patient support group. " PMID: 18653442