Re: methylation and genetics and detoxygenomics

[Guest guest]

" amy " <amydent9@...> wrote:

>

> I had a test called Detoxigenomic profile by Genovations

>

> does the methylation result below mean slow or

> fast methylation and is it the same info as the MTHR

> test people are discussing?

>

>

>

> my methylation was +- COMT gene SNP V158M

The COMT gene affects rate of dopamine, norepinephrine, and

estrogen clearance.

(CYP3A4 in phase I liver metabolism,

and glucoronidation (UGT genes) in phase II,

also affect estrogen clearance.)

All that is oversimplified but a start, may give you

some concept hooks to hang other info on.

> Slow metabolizer Polymophism

> +- NAT2 Gene SNP I114T

>

> +- NAT2 Gene SNP 197Q

>

> FAst metabolizer polymorpism

> +- NAT2 K268R

> all three above are liver/gut

NAT2 gene relates to acetylation, part of phase II liver

metabolism or toxins clearance.

Many persons of EUro ancestry are " slow acetylators " .

There is lots in the medical literature on " slow acetylators " .

> Glutahione conjugation:

> +- GSTp1 I105V brain/skin

>

>

> +- SOD2 A16V mitochonodria

>

> gene CYP1A1 , CYP1B1, CYP2C19 (cytochrome p-450)

> (affects some meds processed through liver)

>

>

> genovations.com

>

> thanks,

> Amy

More info in my compilations/articles

on the genetics of detoxification, e.g. " gen-detox " ,

at url below.

My results data is from www.23andme.com

Carol W.

willis_protocols

Articles in Files.