Re: MTFHR problems and CFS

[Guest guest]

Hi Nil,

Yes, I've been tested for that one, through Dr Amy Yasko's program. I do have

that mutation. I don't remember what specifically it is supposed to do or not do

(or if they know much about it yet), but I do remember that I have that one.

Marcia on

in Salem, Massachusetts

On Jan 12, 2012, at 6:57 PM, nil wrote:

> Hi all

>

> Sorry if this was discussed before. I am new to this.What do you think about

relationship of MTFHR problems and CFS.

>

http://mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutation\

s/2011/11/30/

> Have you been tested for MTFHR problems?

> thanks.

>

>

[Guest guest]

Thanks Marcia.

Which genetic tests would be helpful for us to take? Thanks.

Nil

Re: MTFHR problems and CFS

Hi Nil,

Yes, I've been tested for that one, through Dr Amy Yasko's program. I do have

that mutation. I don't remember what specifically it is supposed to do or not do

(or if they know much about it yet), but I do remember that I have that one.

[Guest guest]

Nil,

There is a whole group devoted to this topic:

CFS_Yasko/ .

Ellen

> Hi all

>

> Sorry if this was discussed before. I am new to this.What do you think about

relationship of MTFHR problems and CFS.

>

http://mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutation\

s/2011/11/30/

> Have you been tested for MTFHR problems?

> thanks.

>

>

[Guest guest]

Hi

Here is a diagram of the mutation and effects etc. mutation 1298 has listed

against it cfs.

http://www.mindmeister.com/12694596/mthfr-related-health-problems

>

> Hi all

>

> Sorry if this was discussed before. I am new to this.What do you think about

relationship of MTFHR problems and CFS.

>

http://mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutation\

s/2011/11/30/

> Have you been tested for MTFHR problems?

> thanks.

>

>

[Guest guest]

I really liked this diagram and the suggestions associated with each mutation.

There are three SNP's associated with MTHFR (that I know of - they may have

discovered others). I had my testing done about 3 years ago by Labcorp and they

only tested for 2 of the SNP's. Quest at that time tested for all three but I

couldn't use them.

While this seems to be cutting edge, the MTHFR is performed by mainstream labs.

Getting a doctor to order it may be difficult. Using an autism doctor was very

helpful to us. The test was covered by my son's insurance (private) and covered

by my Medicare Advantage plan with no issues.

The first MTHFR SNP that is usually discussed is the C677T. I am +- and my son

is ++. Obviously, his dad must be -+. This deals with the use of B vitamins

including folate among many, MANY other things. What we were told by a

Yasko/DAN! doctor was that his body could not convert folic acid (found in food

or supplements) to the form the body uses - methyl tetra hydra folate reductase

(M T H F R). I added spaces to make it easier to read. This is very simplified

- there is much more to this but my memory fails. I can review it and answer

questions as I had a handle on some of this. Also, once one " gear " of the

system breaks or slows down, the other systems also slow down.

http://www.dramyyasko.com/diagrams-listing/

So he takes 800 mcg of the correct form of folate (this is called genetic bypass

- you take the bio-available form to bypass the genetic mutation).

The second SNP is the 1298. He is -- (normal) and I am +-. This has to do with

ammonia removal. So, I am toxic without ingesting processed foods or exposure

to chemicals. My body can't eliminate my own cellular waste. So, all forms of

toxin removal (gentle of course) is helpful. High fiber, pectin, chlorophyll,

caffeine cleanses, any kind of blood purifier. Yucca sprinkled onto protein is

supposed to help but haven't done this religiously.

So, I am fully triggered over to ME/CFIDS/FMS while my son has not. He is

unwell (many allergies, mental fog, etc) but he does not seem to have activated

viruses, unrelenting fatigue (even though he has a form of PEM).

I do think that this is a big piece of the puzzle and have been saving

(unsuccessfully) to get the full Yasko testing done for my son and me.

Marti

> >

> > Hi all

> >

> > Sorry if this was discussed before. I am new to this.What do you think about

relationship of MTFHR problems and CFS.

> >

http://mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutation\

s/2011/11/30/

> > Have you been tested for MTFHR problems?

> > thanks.

> >

> >

[Guest guest]

> While this seems to be cutting edge, the MTHFR is

> performed by mainstream labs. Getting a doctor to

> order it may be difficult. Using an autism doctor

> was very helpful to us. ...

23andme.com has the 2 MTHFR SNPs that Yasko uses, plus

others, and some 800,000 other SNPs that you can look up

by gene or SNP. All for about $200, which is amazing that

we can all have this info directly at low cost. (The current

v.3 does not have Yasko's ACE SNP however). Gone are

the days when one needed to persuade a doctor to order 1-2

dozen SNPs for hundreds of dollars.

I developed over 20 theme genetics compilations in the

last couple of years, many with extensive med lit citations,

all in my Files at url below/end. If you have genetics from

23andme, you can then plug in your own data, etc.

> The first MTHFR SNP that is usually discussed is the C677T.

> I am +- and my son is ++. .....

> The second SNP is the 1298. He is -- (normal) and I am +-.

> This has to do with ammonia removal. So, I am toxic

> without ingesting processed foods or exposure to chemicals.

> My body can't eliminate my own cellular waste.

> So, all forms of toxin removal (gentle of course) is helpful.

> High fiber, pectin, chlorophyll, caffeine cleanses,

> any kind of blood purifier. Yucca sprinkled onto

> protein is supposed to help but haven't done this religiously.

The second SNP 1298 (rs1801131) also deals with folate.

Among persons of Euro ancestry,

42% are wildtype,

45% are heterozygous,

13% are homozygous variant.

(I'm wildtype on 677, heterozygous on 1298.)

For more info, see my files " gen-Yasko-type " , " gen-intro " ,

" gen-inflam " , " gen-detox " etc etc etc, at url below/end.

Carol W.

willis_protocols

Articles in Files.

[Guest guest]

It depends on your genetics.

Some people are over-methylators, some are under-methylators. Mostly, it is best

to think of this as supply and demand as the symptoms can flip flop based on

your current state of health and the supplements that you are taking.

http://drmyhill.co.uk/wiki/CFS_-_The_Methylation_Cycle

http://www.autismsymptoms.net/forum/viewtopic.php?f=4 & t=22329 & start=0

http://www.latitudes.org/forums/index.php?showtopic=837

I have seen a list of the symptoms but can't find it now. I will look tomorrow.

Sometimes, the symptoms can point to being both an under and over methylator so

I have not found these lists very helpful. But generally speaking

under-methylators have high histamine among other things. But this symptom is

pretty standard for methylation (under methylation = high histamine & over

methylation = low histamine.)

This can be measured by blood work (basophils) and your experience (both my son

and I are highly allergic to everything).

Marti

>

> Thanks all for your answers. Anyone studied Pfeiffer's undermethylation

theory?Can we say that MTHFR problems correspond to his UM theory?

> Thanks

> Nil

> Re: MTFHR problems and CFS

>

>

> I really liked this diagram and the suggestions associated with each

mutation.

>

> There are three SNP's associated with MTHFR (that I know of - they may have

discovered others). I had my testing done about 3 years ago by Labcorp and they

only tested for 2 of the SNP's. Quest at that time tested for all three but I

couldn't use them.

>

>

>

[Guest guest]

" nil " <cindiwonderer@...> wrote:

>

> Anyone studied Pfeiffer's undermethylation theory?

> Can we say that MTHFR problems correspond to his UM theory?

> Thanks

> Nil

Does not correspond - confusing use of language.

See my Links > Methylation folder for more info, at url below.

Carol W.

willis_protocols

[Guest guest]

Hi There

We just sent in the 23 & me kit for my son (a Christmas gift). Looking forward to

the results. I will order mine when funds are available.

Paid $99 up front and then $10 a month for 12 months.

Great deal!

>

>

>

> > While this seems to be cutting edge, the MTHFR is

> > performed by mainstream labs. Getting a doctor to

> > order it may be difficult. Using an autism doctor

> > was very helpful to us. ...

>

>

> 23andme.com has the 2 MTHFR SNPs that Yasko uses, plus

> others, and some 800,000 other SNPs that you can look up

> by gene or SNP. All for about $200, which is amazing that

> we can all have this info directly at low cost. (The current

> v.3 does not have Yasko's ACE SNP however). Gone are

> the days when one needed to persuade a doctor to order 1-2

> dozen SNPs for hundreds of dollars.

>

> I developed over 20 theme genetics compilations in the

> last couple of years, many with extensive med lit citations,

> all in my Files at url below/end. If you have genetics from

> 23andme, you can then plug in your own data, etc.

>

>

>

> > The first MTHFR SNP that is usually discussed is the C677T.

> > I am +- and my son is ++. .....

>

>

> > The second SNP is the 1298. He is -- (normal) and I am +-.

> > This has to do with ammonia removal. So, I am toxic

> > without ingesting processed foods or exposure to chemicals.

> > My body can't eliminate my own cellular waste.

> > So, all forms of toxin removal (gentle of course) is helpful.

> > High fiber, pectin, chlorophyll, caffeine cleanses,

> > any kind of blood purifier. Yucca sprinkled onto

> > protein is supposed to help but haven't done this religiously.

>

>

> The second SNP 1298 (rs1801131) also deals with folate.

> Among persons of Euro ancestry,

> 42% are wildtype,

> 45% are heterozygous,

> 13% are homozygous variant.

>

> (I'm wildtype on 677, heterozygous on 1298.)

>

>

> For more info, see my files " gen-Yasko-type " , " gen-intro " ,

> " gen-inflam " , " gen-detox " etc etc etc, at url below/end.

>

> Carol W.

> willis_protocols

> Articles in Files.

>

[Guest guest]

The over- and under- methylation language uses are

different in Pheiffer and Yasko.

For example, Pheiffer gives methyl

donors to his " over-methylated " biotype.

Carol W.

willis_protocols

>

> Sorry to but in. Amy yasko says over methylator are those comt ++ vdr taq --

and under methylator are comt -- vdr taq ++.

>

> I'm comt +- vdr taq ++ so lean towards an undermethylator. I macth many

symptoms of um and histamine always ranked high.

>

> Sent using BlackBerry® from Orange

>

> Re: Re: MTFHR problems and CFS

>

> Hi Marti

>

> Thanks

> I bodies are so damaged from long term illness that I think we need to check

times when we were young in order to be able to decide if we are OM or UM.When I

think my early times I think I fit into UM. Lately I have symptoms from UM's and

OM's.

>

> I was also wondering if there is any connection between Pfeiffer's over

Methylation concept and specific MTHFR or other genetic problems?

> Best wishes

> nil