Deplin and Leukovorin

[Guest guest]

Does anyone have experience with either Deplin or Leukovorin?

Rich, I'm especially curious if either of these would be useful substitutes in

the simplified methylation protocol or if you have any thoughts on the matter.

Thanks!

Peggy

[Guest guest]

Hi, Peggy.

Deplin is L5-methyltetrahydrofolate, the same substance as in FolaPro,

Metafolin, MethylMate B, and Quatrefolic, but the dosage is quite large (7,500

or 15,000 micrograms). In the simplified methylation protocol, the dosage is

much smaller (see below).

Leucovorin is folinic acid (also called 5-formyltetrahydrofolate), as is used in

the simplified methylation protocol.

Yes, I think these could be substituted, so long as the dosages were kept

equivalent.

Best regards,

Rich

March 30. 2011

SIMPLIFIED TREATMENT APPROACH

FOR LIFTING THE PARTIAL METHYLATION CYCLE BLOCK

IN CHRONIC FATIGUE SYNDROME—March 30, 2011 Revision

Rich Van Konynenburg. Ph.D.

(Based on the full treatment program

developed by Amy Yasko, Ph.D., N.D.

which is used primarily in treating autism [1])

SUPPLEMENTS

1. General Vitamin Neurological Health Formula [2]: Start with ¼ tablet and

increase dosage as tolerated to 2 tablets daily

2. Hydroxy B12 Mega Drops [3]: 2 drops under the tongue daily

3. MethylMate B [4]: 3 drops under the tongue daily

4. Folinic acid [5]: ¼ capsule daily

5. Phosphatidyl Serine Complex [6]: 1 softgel capsule daily (or lecithin, see

below)

All these supplements can be obtained from http://www.holisticheal.com.

The fourth supplement comes in capsules that contain 800 mcg. It will be

necessary to open the capsules, dump the powder onto a flat surface, and

separate it into quarters using a knife to obtain the daily dose. The powder can

be taken orally with water, with or without food.

These supplements can make some patients sleepy, so in those cases they take

them at bedtime. In general, they can be taken at any time of day, with or

without food.

Phosphatidyl serine can lower cortisol levels. Patients who already have low

evening cortisol levels may wish to substitute lecithin [7] (at one softgel

daily) for supplement number 5 above. Lecithin is also available from

http://www.holisticheal.com.

For those allergic to soy, lecithin from other sources is available.

GO SLOWLY. As the methylation cycle block is lifted, toxins are mobilized and

processed by the body, and this can lead to an exacerbation of symptoms. IF THIS

HAPPENS, try smaller doses, every other day. SLOWLY work up to the full dosages.

Although this treatment approach consists only of nonprescription nutritional

supplements, a few patients have reported adverse effects while on it.

Therefore, it is necessary that patients be supervised by physicians while

receiving this treatment.

[1] Yasko, Amy, Autism, Pathways to Recovery, Neurological Research Institute,

2009, available from http://www.holisticheal.com or Amazon.

[2] General Vitamin Neurological Health Formula is formulated and supplied by

Holistic Health Consultants LLC.

[3] Hydroxy B12 Mega Drops is a liquid form of hydroxocobalamin (B12), supplied

by Holistic Health Consultants. 2 drops is a dosage of 2,000 mcg.

[4] MethylMate B is a liquid form of (6s)-methyltetrahydrofolate supplied by

Holistic Health Consultants, based on Extrafolate S, a trademark of Gnosis

S.P.A. 3 drops is a dosage of 210 mcg.

[5] Folinic acid is 5-formyltetrahydrofolate. ¼ capsule is a dosage of 200 mcg.

[5] Phosphatidyl Serine Complex is a product of Vitamin Discount Center. 1

softgel is a dosage of 500 mg.

[7] Lecithin is a combination of phospholipids without phosphatidylserine. One

softgel is a dosage of 1,200 mg.

>

> Does anyone have experience with either Deplin or Leukovorin?

>

> Rich, I'm especially curious if either of these would be useful substitutes in

the simplified methylation protocol or if you have any thoughts on the matter.

>

> Thanks!

> Peggy

>

>

>