Amino Acid Disturbances in ME/CFS

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--- [CO-CURE] res: Amino Acid Disturbances in ME/cfs

Date: Sun, 24 Jun 2012 12:17:46 +0200

From: Jan van Roijen <j.van.roijen@...>

Reply- Jan van Roijen <j.van.roijen@...>

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http://bit.ly/O9izNJ

Clinica Chimica Acta

International Journal of Clinical Chemistry and

Diagnostic Laboratory Medicine

Available online 21 June 2012

In Press, Accepted Manuscript

Purchase $41.95:http://bit.ly/O9izNJ

NMR metabolic profiling

of serumidentifies amino

aciddisturbances in Chronic

Fatigue Syndrome

W. Armstronga, b, Neil R.

McGregorc, R. Sheedyd, Ian Buttfielde,

Henry L. Buttb, f, R. Gooleya, b,

a Department of Biochemistry and Molecular

Biology, University of Melbourne, Parkville,

3010, Australia

b Bio21 Molecular Science and Biotechnology

Institute, University of Melbourne, Parkville,

3010, Australia

c Faculty of Medicine, Dentistry & Health Sciences,

University of Melbourne, Parkville, 3010,

Australia

d Department of Zoology, The University of

Melbourne, Parkville, , 3010, Australia

e Child Development Centre, 90 Unley Road, Unley,

South Australia 5061, Australia

f Bioscreen, Building 404, Room G6, 2 Park Drive,

Parkville, 3010, Australia

Corresponding author at: 30 Flemington Road,

Parkville, VIC Australia 3010. Tel.: + 61 3 8344

2273; fax: + 61 3 9348 1421.

Received 27 April 2012. Revised 15 June 2012.

Accepted 15 June 2012. Available online 21 June 2012.

Abstract

Chronic fatigue syndrome (CFS) is a debilitating

multisystem disorder characterized by long-term

fatigue with a variety of other symptoms including

cognitive dysfunction, unrefreshing sleep, muscle

pain, and post-exertional malaise.

It is a poorly understood condition that occurs in ~

5 in every 1000 individuals.

We present here a preliminary study on the

analysis of blood samples from 11 CFS and 10

control subjects through NMR metabolic profiling.

Identified metabolites that were found to be

significantly altered between the groups were

subjected to correlation analysis to potentially

elucidate disturbed metabolic pathways.

Our results showed a significant reduction of

glutamine (P = 0.002) and ornithine (P < 0.05) in

the blood of CFS samples.

Correlation analysis of glutamine and ornithine with

other metabolites in the CFS sera showed

relationships with glucogenic amino acids and

metabolites that participate in the urea cycle.

This indicates a possible disturbance to amino acid

and nitrogen metabolism. It would be beneficial to

identify any potential biomarkers of CFS for

accurate diagnosis of the disorder.

Copyright © 2012 Published by Elsevier B.V.

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