blood brain barrier, carcinogens, and brain cancer/nitrates amides

[Guest guest]

" The blood-brain barrier is effective at keeping many potentially

toxic agents in the bloodstream from reaching the glial cells that

give rise to most brain cancers [32]. In studies with experimental

animals, the most potent known chemical neurocarcinogens are

nitrosamides, such as nitrosoureas, which can cross the bloodbrain

barrier [33-36]. Such compounds can be formed in the

stomach from nitrites and amides in the diet. Whether they are

important carcinogens in humans is an unresolved issue [2,37,38]. "

"

http://seer.cancer.gov/publications/mecc/mecc_brain.pdf

[33] Druckrey H. Specific carcinogenic and teratogenic effects of `indirect'

alkylating methyl and ethyl compounds, and their dependency on stages

of ontogenic developments. Xenobiotica 1973;3:271-303.

[34] Kleihues P, Lantos PL, Magee PN. Chemical carcinogenesis in the nervous

system. Int Rev Exp Pathol 1976;15:153-232.

[35] Magee PN, Montesano R, Preussmann R. N-nitroso compounds and

related carcinogens. In: Searle CE, editor. Chemical carcinogens, ACS

monograph 173. Washington (DC): American Chemical Society; 1976. p.

491-625.

[36] Kleihues P, Aguzzi A, Wiestler OD. Cellular and molecular aspects of

neurocarcinogenesis. Toxicol Pathol 1990;18:193-203.

[37] Preston- S, BE. N-nitroso compounds