Re: Digest Number 2536

[Guest guest]

" . . . I have discovered grapefruit juice is very satisfying!  I'll have to switch to something else later I know . . . "  Amy

Amy (and others), as far as I know grapefruit is a problem ONLY if you are taking specific drugs that work badly with it. Otherwise, grapefruit is a good, nutritious food. It's very important to check and double-check that each drug you use is compatible with grapefruit. Your doctor may not know, so it's up to you to find out.

Harper

[Guest guest]

In a message dated 4/9/2004 2:02:19 PM Eastern Daylight Time,

writes:

From: " beautifulmaxine " <beautifulmaxine@...>

Subject: Re: burping CLO

Hi ,

After taking a high quality lemon-flavoured fish oil for a couple of

years, I decided to try CLO this past winter. I couldn't find the

lemon-flavoured one where I live (like Carlson brand) so settled for

some unflavoured... whoosh!!

Ever since starting the fish oil/clo, I did notice that some days it

would repeat on me for hours and other days I had no problem. It may

be a matter of how well fats are being digested and could relate, at

least in my case, to the gallbladder. My naturopath suggested a

digestive enzyme containg ox bile... this has helped me.

I've read that some people digest the fish oil/clo better when taken

on an empty stomach (??), whereas others do better taking it with a

meal. Experiment I guess

all the best,

Eleanor

---------------

We take both FIsh oil (10 grams a day) ad cod liver oil as gel caps and have

NO problem.

mjh

http://foxhillfarm.us/FireBasil/

[Guest guest]

Hi Greg,

I am so glad for you and Savannah that she can be controlled so well

just on Motrin.

What is REIKI?

Stacia and Hunter,8,systemic,iritis

>she does REIKI and it seems to work excellent

[Guest guest]

Regarding PNS damage or perpherial neuropathy....................

I testified in a case recently where gliotoxins were found to explain the

plaintiff's PNS damage or peripheral neuropathy. There are other tremorigens

but gliotoxin may the best understood.

Put " Gliotoxin " in the search box and get 300 scientific articles. Let me

know if I can help but my free time is very limited with about 100 mold

claims nationwide and testifying about 80 times a year.

_PUBMED SEARCHES_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Search & DB=PubMed)

( _http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Search & DB=PubMed_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Search & DB=PubMed) )

Dr. L. Lipsey

Toxicologist and Instructor

University of North Florida

Univ. Fla. Poison Control, Jax, Board

_www.richardlipsey.com_ (http://www.richardlipsey.com/)

Here are the articles on " Tremorigen "

1: Neurotoxicol Teratol. 2004 Jan-Feb;26(1):113-20. _Related Articles,_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Display & dopt=pubmed\

_p

ubmed & from_uid=15001220) _Links_ (javascript:PopUpMenu2_Set(Menu15001220)

Toxicological evaluation of the staircase test for assessing fine motor

movements.

_Samsam TE_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Samsam\

+TE " [Author]) , _Gadrinab LG_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Gadrin\

ab+LG " [Author]) , _Bushnell

PJ_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Bushne\

ll+PJ " [Author]) .

Neurotoxicology Division, MD B105-04, National Health and Environmental

Effects Research Laboratory, U.S. Environmental Protection Agency, Research

Triangle Park, NC 27711, USA.

A variety of tests have been developed to study neurotoxicant-related

changes in motor function. However, despite recent advances, there remains a

need

for simple and specific tests of fine motor movements. Accordingly, we chose

to evaluate whether a method developed for measuring changes in skilled

movements following motor pathway lesions in rodents would provide a sensitive,

specific, and economical approach to assessing fine motor control in the

toxicology laboratory. We measured skilled paw reaching using the " staircase

test "

developed by Montoya et al. [Prog. Brain Res. 82 (1990) 459], in which a rat

retrieves food pellets by reaching down from a central platform to a series of

descending steps on either side, grasping the pellets in its forepaw, and

lifting them to its mouth. Staircase boxes were scaled for the body weights of

young adult male (350 g) and female (250 g) Long- rats. Studies were

conducted using harmaline, a tremorigen; scopolamine; methyl scopolamine; and

2,4-dithiobiuret (DTB), a compound that causes muscle weakness by interfering

with cholinergic transmission at the neuromuscular junction. Harmaline (0,

1.0, 3.0, and 10.0 mg/kg) reduced pellet retrieval only at a dose that also

caused visible tremor. Both scopolamine (0, 0.1, 0.3, and 1.0 mg/kg) and methyl

scopolamine (0, 0.104, 0.312, and 1.04 mg/kg) impaired pellet retrieval;

scopolamine was more effective than methyl scopolamine. DTB (5 daily doses of

0,

0.1, 0.2, and 0.5 mg/kg) had no effect on retrieval, even when causing visible

signs of weakness. These data cast doubt on the utility of this method for

detecting and quantifying subtle chemical-induced changes in motor function in

rats.

Publication Types:

* Evaluation Studies

PMID: 15001220 [PubMed - indexed for MEDLINE]

____________________________________

2: Mol Pharmacol. 1989 Mar;35(3):319-23. _Related Articles,_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Display & dopt=pubmed\

_pubmed & from_

uid=2538710) _Links_ (javascript:PopUpMenu2_Set(Menu2538710)

The tremorigen aflatrem is a positive allosteric modulator of the

gamma-aminobutyric acidA receptor channel expressed in Xenopus oocytes.

_Yao Y_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Yao+Y " \

[Author]) , _ AB_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " +\

AB " [Author]) , _Baur R_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Baur+R\

" [Author]) ,

_Sigel E_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Sigel+\

E " [Author]) .

Department of Pharmacology, University of Bern, Switzerland.

Aflatrem, a mycotoxin from Aspergillus flavus, potentiates the

gamma-aminobutyric acid (GABA)-induced chloride current. This positive

allosteric

regulatory action of aflatrem was quantitatively studied on the GABAA receptor

channel expressed in Xenopus oocytes after injection with chick brain mRNA

under

voltage-clamp conditions. In this model system, aflatrem potentiates the

current induced by 5 microM GABA in a concentration-dependent manner.

Half-maximal

potentiation was obtained with 2.4 microM aflatrem and maximal stimulation of

the GABA (5 microM) response was more than 10-fold. The potentiation was not

associated with a change of the reversal potential of the GABA-induced

current. In the presence of 2 microM aflatrem, the GABA dose-response curve

shifted to lower concentrations, with the Ka decreasing from 28 to 7 microM and

the

Hill coefficient, n, from 1.5 to 0.8, as measured at a membrane potential of

-100 mV. At saturating concentration of GABA (250 microM), aflatrem (10

microM) was still able to enhance the current by about 21%. Further experiments

suggest that the site of action of aflatrem on the GABAA receptor channel

complex is different from that of benzodiazepines, pentobarbital, and

picrotoxin.

Aflatrem (10 microM) had no significant effect on the coexpressed

voltage-dependent sodium and calcium channels and on the kainate channel. The

potentiating action of aflatrem on the GABAA receptor channel may explain the

initial

symptoms of intoxication caused by aflatrem in vivo, i.e., diminished

activity or immobility of the affected animal.

PMID: 2538710 [PubMed - indexed for MEDLINE]

____________________________________

3: Brain Res. 1986 Jul 30;379(1):147-50. _Related Articles,_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Display & dopt=pubmed\

_pubmed & from_u

id=2427159) _Links_ (javascript:PopUpMenu2_Set(Menu2427159)

Inhibition of ornithine decarboxylase alters neurological responsiveness to

a tremorigen.

_Tilson HA_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Tilson\

+HA " [Author]) , _Emerich D_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Emeric\

h+D " [Author]) , _Bondy SC_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & term= " Bondy+\

SC

" [Author]) .

Difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase

(ODC; 200-800 mg/kg, s.c.), to rats has no detectable behavioral effects using

a

battery of tests to assess sensorimotor function. In contrast, the induction

of tremor by chlordecone, a neurotoxic agent that affects neuronal ionic

processes, is significantly attenuated by pretreatment with DFMO. The effects

of

DFMO on chlordecone-induced tremor were reversed by pretreatment with

putrescine. DFMO had no effects on p,p'-DDT, a tremorigen having a mechanism of

action different from chlordecone. These findings imply that polyamines may

play

a role in select neuronal processes.

PMID: 2427159 [PubMed - indexed for MEDLINE]

(http://www.richardlipsey.com/)

[Guest guest]

I read with interest the post about " stress and cancer returning " , my fiance

is still in remission after 3 years and 3 months from advanced bowel cancer

that reached the stomach lining using alternatives after surgery and half a

course of chemo at the time of diagnosis. Recently she developed symptoms

similar to those experienced by paranoid schizophrenics and her

stress/paranoia etc. was so great she has had to take an antipsychotic

'zyprexa' to alleviate her symptoms. It is probably the lesser of two evils

(although there is some evidence that antidepressants can prevent cancer due

to its effect on the neurons in the brain or something

http://www.webmd.com/content/article/120/113759 ) since without the

psychotic she was very very stressed, anxious and not sleeping well

Nick