s- Syndrome - ibuprofen

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The PubMed search

ibuprofen AND stevens AND johnson

generated 7 citations (1-7).

Lynne Arnold wrote:

Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe Side

Effects

Is there any difference between Motrin and generic ibuprofen? Because the

suit seems to be specifically about Motrin. Is that because this company

originated ibuprofen?

Lynne

ibuprofen AND stevens AND johnson

1: J Pediatr. 2004 Aug;145(2):273-6.

Acute vanishing bile duct syndrome after ibuprofen therapy in a child.

Taghian M, Tran TA, Bresson-Hadni S, Menget A, Felix S, Jacquemin E.

Pediatric Unit, Vesoul Hospital, Vesoul, France.

We report the case of a 10 year-old girl who had s- syndrome and

cholestasis after ibuprofen therapy. Liver histology was compatible with

vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver

tests

normalized within 7 months. This report confirms that ibuprofen may induce

acute

vanishing bile duct syndrome.

Publication Types:

Case Reports

Review

Review of Reported Cases

PMID: 15289784 [PubMed - indexed for MEDLINE]

2: Dig Dis Sci. 2001 Nov;46(11):2385-8.

s- Syndrome and cholestatic hepatitis.

Morelli MS, O'Brien FX.

Department of Internal Medicine, Section of General Internal Medicine, Wake

Forest University School of Medicine, Winston-Salem, North Carolina 27157,

USA.

s- Syndrome (SJS) is a rare but severe dermatological condition

that typically occurs after the ingestion of medications such as nonsteroidal

drugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of the

syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa,

gastrointestinal tract, and genitourinary tract. Cholestatic liver disease,

which may precede the skin manifestations of SJS, has been reported to

occur in

SJS, but the medical literature has only 10 case reports describing this

phenomenon (1-9). We report the case of a 19-year-old female with SJS and

cholestatic liver disease. A discussion of the underlying pathophysiology

of SJS

and its treatment follows.

Publication Types:

Case Reports

Review

Review of Reported Cases

PMID: 11713940 [PubMed - indexed for MEDLINE]

3: Int J Dermatol. 1999 Nov;38(11):878-9.

Pentoxyfylline in toxic epidermal necrolysis and s- syndrome.

Sanclemente G, De la Roche CA, Escobar CE, Falabella R.

Publication Types:

Case Reports

Letter

PMID: 10583942 [PubMed - indexed for MEDLINE]

4: Int J Dermatol. 1998 Nov;37(11):833-8.

Drugs causing fixed eruptions: a study of 450 cases.

Mahboob A, Haroon TS.

Department of Dermatology, King Medical College/Mayo Hospital, Lahore,

Pakistan.

BACKGROUND: Drug eruptions are among the most common cutaneous disorders

encountered by the dermatologist. Some drug eruptions, although trivial, may

cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. The

diagnostic hallmark is its recurrence at previously affected sites. OBJECTIVE:

We evaluated 450 FDE patients to determine the causative drugs. RESULTS: The

ratio of men to women was 1:1.1. The main presentation of FDE was circular

hyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema,

urticaria, dermatitis, periorbital or generalized hypermelanosis. Occasionally

FDE mimicked lichen planus, erythema multiforme, s- syndrome,

paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen

planus

actinicus, discoid lupus erythematosus, erythema annulare centrifugum,

pemphigus

vulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis.

Cotrimoxazole was the most common cause of FDE. Other drugs incriminated were

tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid,

mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin,

ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac

sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin,

allopurinol, orphenadrine, and albendazole. CONCLUSIONS: Cotrimoxazole was the

most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel

pamoate,

clindamycin, and albendazole were reported for the first time. FDE may have

multiform presentations.

PMID: 9865869 [PubMed - indexed for MEDLINE]

5: Gastroenterology. 1998 Sep;115(3):743-6.

Drug-associated acute-onset vanishing bile duct and s-

syndromes in

a child.

Srivastava M, -Atayde A, Jonas MM.

Combined Program in Gastroenterology, Department of Medicine, Children's

Hospital, Boston, Massachusetts, USA.

Acute vanishing bile duct syndrome is a rare but established cause of

progressive cholestasis in adults, is most often drug or toxin related, and is

of unknown pathogenesis. It has not been reported previously in children.

s- syndrome is a well-recognized immune complex-mediated

hypersensitivity reaction that affects all age groups, is drug or infection

induced, and has classic systemic, mucosal, and dermatologic manifestations. A

previously healthy child who developed acute, severe, rapidly progressive

vanishing bile duct syndrome shortly after s- syndrome is

described; this was temporally associated with ibuprofen use. Despite therapy

with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic

disease was unrelenting, with cirrhosis shown by biopsy 6 months after

presentation. This case documents acute drug-related vanishing bile duct

syndrome in the pediatric age group and suggests shared immune mechanisms

in the

pathogenesis of both s- syndrome and vanishing bile duct

syndrome.

Publication Types:

Case Reports

PMID: 9721172 [PubMed - indexed for MEDLINE]

6: J Am Acad Dermatol. 1985 May;12(5 Pt 1):866-76.

Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.

Bigby M, Stern R.

The nonsteroidal anti-inflammatory drugs are one of the most commonly

prescribed

classes of drugs used in medical practice. This review discusses the diverse

cutaneous reactions associated with nonsteroidal anti-inflammatory drugs.

Adverse cutaneous reactions occur most frequently with benoxaprofen,

piroxicam,

sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most

serious adverse cutaneous reactions, s- syndrome and toxic

epidermal necrolysis, appear to be most often associated with sulindac and

phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar

pyrrole

derivatives, have been associated with a disproportionate number of cases of

anaphylactoid reactions. Among the currently marketed nonsteroidal

anti-inflammatory drugs, piroxicam appears to have the highest rate of

phototoxic reactions. This phototoxic eruption is most often vesiculobullous.

Publication Types:

Review

PMID: 3159761 [PubMed - indexed for MEDLINE]

7: N Y State J Med. 1978 Jul;78(8):1239-43.

s- syndrome plus toxic hepatitis due to ibuprofen.

Sternlieb P, RM.

Publication Types:

Case Reports

PMID: 276660 [PubMed - indexed for MEDLINE]

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