Vaccines/Autism - 65% of ASD Kids Have Mitichondrial Disorder

[Guest guest]

And I would suggest that the vaccine caused the mitochondrial

dysfunction to begin with - also see recent info I sent from

on Vitamin C

65% of children with ASD have mitochondrial disorder but was that test

done BEFORE vaccines did their damage? NO!

Sheri

From cgmiller@...

Please circulate - latest research below. The US vaccines-to-autism

case of Hannah Poling is not new or rare.

At an American Academy of Neurology meeting last Sunday it was

revealed in a recent research paper " Oxidative Phosphorylation

(OXPHOS) Defects in Children with Autistic Spectrum Disorders " (see

abstract below) that 65% of children with Austistic Spectrum Disorders

assessed were found to have mitochondrial disorder (MtD) and so were

always at risk of autism caused by one or more vaccines.

Write to your political representatives. Keep asking them " what are

you doing about this for child health safety and all children " and

keep writing and keep asking. If you are in the UK, it's easier with

www.writetothem.com. Ask all your relatives and friends to write to

their political representatives.

The new figures from the AAN meeting correlate with 68% of regressive

autism cases following MMR being found to have measles virus RNA in

their cerebro spinal fluid (CSF). This was found using sensitive

molecular laboratory detection methods. But bear in mind the problem

is caused by vaccines in general and not just MMR, as the Hannah

Poling case shows.

Looks like the UK's The Sunday Times, and its editor Witherow

have a lot of explaining to do with all their attacks on

Wakefield now turning out to be false. Phone and write to Witherow

(see address below) and ask him what he is going to do about this, ask

him when he is going to resign

Here are contact details for The Sunday Times editor, Witherow:-

email: letters@...

Witherow Esq

Editor

The Sunday Times

1 Pennington Street

London E1 9XN

Main - Tel: 020 7782 5000 Fax: 020 7782 5658

Here is the abstract of the AAN paper, courtesy of Professor Jeff

Bradstreet of Thoughtful House, Austin, Texas:-

" Oxidative Phosphorylation (OXPHOS) Defects in Children with Autistic

Spectrum Disorders

[iN1-1.004]

Shoffner, C. Hyams, Genevieve N. Langley, Atlanta, GA

OBJECTIVE: To retrospectively survey patients with autistic spectrum

disorders that were evaluated clinically for mitochondrial disease and

to assess the clinical and laboratory features of this group of

patients. BACKGROUND: Autism is a developmental disorder characterized

by disturbance in language, perception and socialization. A variety of

biochemical, anatomical and neuroradiographical studies imply a

disturbance of brain energy metabolism in autistic patients. Recent

studies confirmed the previously reported high frequency of

biochemical markers of mitochondrial dysfunction, namely

hyperlactacidemia and increased lactate/pyruvate ratio, in a

significant fraction of 210 autistic patients. (J Autism Dev Disord,

2006. 36:1137) Although rare, Mecp2 mutations can produce autistic

features and the mouse model has significant mitochondrial defects.

(Mol Cell Biol, 2006. 26: 5033) Additional genetic defects associated

with mitochondrial dysfunction include inverted 15q11-13 duplication

(Complex III defect) (Ann Neurol, 2003,53,801), A3243G mutation

(mitochondrial transfer RNALeucine(UUR) gene, mtDNA depletion(J

Pediatr, 2004,144,81), G8363A mutation (mitochondrial transfer

RNALysine gene. (J Child Neurol, 2000,15,357). DESIGN/METHODS:

Retrospective analysis of 37 children with autistic spectrum

disorders. Clinical, biochemical, metabolic, and genetic data is

assessed. RESULTS: Twenty four children (65%) had skeletal muscle

OXPHOS defects: Complex I (16), Complex I and Complex III (5), Complex

III (1), Complex I and Complex IV (2). Thirteen (35%) had normal

skeletal muscle OXPHOS enzyme activities for Complexes I-IV. Clinical,

metabolic, protein chemistry, and sequencing of coding regions of the

mitochondrial DNA will be reported. CONCLUSIONS/RELEVANCE: Most

children with autistic spectrum disorders do not have recognizable

abnormalities on a broad range of imaging, metabolic and genetic

studies. However, a subset of patients do harbor significant defects

in oxidative phosphorylation function. Complex I abnormalities are the

most frequently encountered defect. Recognition of these children is

important for understanding how genes that produce autistic spectrum

disorders impact mitochondrial function. Supported by: Horizon

Molecular Medicine.

Category - Neurogenetics and Gene Therapy

SubCategory - Other

Sunday, April 13, 2008 2:45 PM

Platform Session: Integrated Neuroscience: Autism (2:00 PM-3:15 PM)

Annual Meeting American Academy of Neurology "