T. Schultz Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder

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Autism, Vol. 12, No. 3, 293-307 (2008)

DOI: 10.1177/1362361307089518

© 2008 The National Autistic Society, SAGE Publications

Acetaminophen (paracetamol) use,

measles-mumps-rubella vaccination, and autistic disorder

http://aut.sagepub.com/cgi/content/abstract/12/3/293

Acetaminophen (paracetamol) use,

measles-mumps-rubella vaccination, and autistic disorde

The results of a parent survey

T. Schultz

University of California San Diego, and San Diego

State University, USA,

<mailto:.schultz@...>.schultz@...,

<mailto:stevendri@...>stevendri@...

Hillary S. Klonoff-Cohen

University of California San Diego, USA

Deborah L. Wingard

University of California San Diego, USA

Natacha A. Akshoomoff

University of California San Diego, USA

Caroline A. Macera

San Diego State University, USA

Ming Ji

San Diego State University, USA

The present study was performed to determine

whether acetaminophen (paracetamol) use after the

measles-mumps-rubella vaccination could be

associated with autistic disorder. This

case-control study used the results of an online

parental survey conducted from 16 July 2005 to 30

January 2006, consisting of 83 children with

autistic disorder and 80 control children.

Acetaminophen use after measles-mumps-rubella

vaccination was significantly associated with

autistic disorder when considering children 5

years of age or less (OR 6.11, 95% CI 1.42­26.3),

after limiting cases to children with regression

in development (OR 3.97, 95% CI 1.11­14.3), and

when considering only children who had

post-vaccination sequelae (OR 8.23, 95% CI

1.56­43.3), adjusting for age, gender, mother's

ethnicity, and the presence of illness concurrent

with measles-mumps-rubella vaccination. Ibuprofen

use after measles-mumps-rubella vaccination was

not associated with autistic disorder. This

preliminary study found that acetaminophen use

after measles-mumps-rubella vaccination was associated with autistic disorder.