2006: Are vaccines responsible for the epidemic of anaphylaxis in young children today?

[Guest guest]

http://www.whale.to/vaccines/hoffman.html

Anaphylactic children - canaries in the public health mine shaft?

Are vaccines responsible for the epidemic of

anaphylaxis in young children today?

by <http://www.whale.to/vaccines/hoffman_h.html>Rita Hoffman

July 2006 [<http://www.whale.to/vaccines/hoffman.doc>Word version]

In the presentation speech as winner of the 1913

Nobel Prize in Medicine for his work with

anaphylaxis, Richet said, " We are

so constituted that we can never receive other

proteins into the blood than those that have been

modified by digestive juices. Every time alien

protein penetrates by effraction, the organism

suffers and becomes resistant. This resistance

lies in increased sensitivity, a sort of revolt

against the second parenteral injection which

would be fatal. At the first injection, the

organism was taken by surprise and did not

resist. At the second injection, the organism

mans its defences and answers by the anaphylactic

shock. " In naming " anaphylaxis " , Richet

described, " Phylaxis, a word seldom used, stands

in the Greek for protection. Anaphylaxis will

thus stand for the opposite. Anaphylaxis, from

its Greek etymological source, therefore means

that state of an organism in which it is rendered

hypersensitive, instead of being

protected. " Richet concluded his lecture by

saying, " Seen in these terms, anaphylaxis is a

universal defense mechanism against the

penetration of heterogenous substances in the

blood, whence they can not be eliminated. "

[<http://www.whale.to/vaccines/hoffman.html#1%5D>1]

Vaccine antigens injected subcutaneously or

intramuscularly prompt the immune system to

create antibodies in the blood against those

antigens. Has medicine, which has used

vaccinations containing " alien proteins " as its

cornerstone to control infectious diseases, been

on the wrong track by injecting heterogenous

substances [originating in an outside source;

especially: derived from another species]

[<http://www.whale.to/vaccines/hoffman.html#2>2]

into human beings to " control " disease? What

would be the general state of health today if 200

years ago medicine had taken the path of

discovering the keys to promoting a strong,

unadulterated immune system in conjunction with

increased nutrition, vitamin and mineral

supplementation along with better

sanitation? Has medicine produced false

protection by injecting alien proteins via

vaccination which, as Richet pointed out in his

lecture, can render us hypersensitive instead of being protected?

This hypersensitive state called anaphylaxis is

now epidemic in young children who live every day

of their life under threat of death from

everyday, normally harmless substances. The

numbers are staggering. According to Health

Canada's web site, " It is estimated that 600,000

Canadians (two percent of the population) may be

affected by life-threatening allergies, and the

numbers are increasing, especially among

children. "

[<http://www.whale.to/vaccines/hoffman.html#3>3]

In 2005 Ontario passed a law to protect

anaphylactic students at school while The Toronto

Star reported an estimated 40,000 children in

Ontario with anaphylaxis. [<http://www.whale.to/vaccines/hoffman.html#4>4]

The recent deaths of three Canadian teenagers

exposed to minute quantities of allergen have

caused a world wide media explosion of

anaphylaxis stories. Everyone is asking - why do

we have so many kids with peanut allergies? Why

have schools banned peanut butter

sandwiches? Why are kids dying?

Richet knew that foreign proteins penetrating the

body could cause anaphylaxis back in 1913. Some

doctors, allergists and anaphylaxis organizations

blame skin creams containing peanut oil and North

America's roasting of peanuts for the epidemic of

anaphylaxis. And perhaps weary of saying that

increased consumption of peanuts is the cause of

the increase in peanut allergy some are

mentioning the " hygiene hypothesis " as a

cause. A few are even mentioning the " v "

word. Dr. Bruce was quoted in a February

21, 2006 Newsday article regarding the hygiene

hypothesis. " The theory is that because U.S.

children 'use antibacterial soap, get antibiotics

at the first sign of a runny nose and are

vaccinated for every potential thing out there,'

their immune systems do not spend time producing

anti-infectious responses to all the diseases

they will never get. Instead, their immune

systems may be 'shunting their responses to

produce things [anti-infectious responses] which are more allergic in nature.' "

In a May 18, 2005 CNN article, in an attempt to

explain the peanut allergy epidemic, Dr.

Woods of s Hopkins University stated, " The

more your immune system is kept busy by exposure

to germs and infections early in life, the less

time it can devote to things like allergy. " Anne

Munoz-Furlong, CEO and founder of U.S. based The

Food Allergy & Anaphylaxis Network (FAAN) in the

same article says " Perhaps our homes are too

clean - we've done too much to take away the job

of the immune system. We don't have parasites, a

lot of the childhood diseases you vaccinate and

don't have, so maybe for some people, the immune

system is looking for something to do and

decides, 'Aha, I don't like milk' or 'I don't

like peanuts,' and the body then attacks the food

protein as if it were an enemy invader. " Somehow

I think our God given immune systems are smarter

than that - that is, if left to do the job without any interference!

Anaphylaxis is not the only allergic disease on

the rise. On March 31, 2006 Reuters reported

that " Allergies such as hay fever are reaching

epidemic proportions in Europe and a failure to

treat them properly is creating a mounting bill

for society and the healthcare system...Around

one third of the European population has some

kind of allergy, while one in two children in

Britain will have allergies by 2015, costing

millions of euros in medical bills, lost work

days and even impaired concentration in school

pupils. " The article goes on to describe,

" Allergies were most prevalent in Britain and

Ireland, as well as other English speaking

countries like Canada, Australia and the United

States, Burney said, adding they were also

becoming more widespread in new European Union

member states. " On May 5, 2005 The Toronto Star

devoted an entire section to allergies and

asthma. An article about eczema states, " In

Canada, this incurable skin condition that causes

dryness, crusting and thickening afflicts between

2 million and 5 million people. Experts report

its incidence has tripled since 1970. "

In 2002, prominent Canadian allergist Dr.

Vadas went as far to say, in a television show on

severe allergies, " There are factors to do with

how we vaccinate our kids very early on in life,

how much drugs, antibiotics we give the kids

early on in life all of which tend to predispose

more towards allergy. " But when asked, " Do you

think early vaccination is not a good thing? " he

replied, " No, I think it's a wonderful

thing. It's an absolutely crucial thing from the

standpoint of public health to minimize the

likelihood of severe infections, but on the other

hand one of the spin offs is that there are a

certain proportion of the population that are

going to be more prone to developing allergies as

a consequence of that.” [<http://www.whale.to/vaccines/hoffman.html#5>5]

In a February 20, 2006 Globe and Mail article

entitled " Is clean living making us sick? Hygiene

hypothesis on food allergies " , Dr. Vadas followed

a " party line " , eliminating the " v " word. The

" party line " to explain this, he said " holds that

consumption of peanuts and the peanut protein has

increased in Western societies. As a result, the

more exposure to peanuts, the more people will be

found to be allergic to them. " It sounds like a

" party line " to protect the vaccine status

quo. This does nothing to explain the explosion

of other unusual anaphylactic allergies in

children to foods like kiwi, sesame, soybean and

tree nuts. Parents should be receiving

information regarding all of the potential risks

and benefits of vaccines to make an informed

decision about vaccinating their children. I was

never told that one of the potential " spin offs "

of my child being vaccinated would be that he

would live every day of his life under threat of death!

If increased consumption of peanut is the cause

of peanut anaphylaxis, then why don't the Chinese

and Indonesians, who consume large quantities of

peanut, have the peanut anaphylaxis problems of

the western industrialized nations?

[<http://www.whale.to/vaccines/hoffman.html#6>6]

[<http://www.whale.to/vaccines/hoffman.html#7>7]

China and Indonesia do not routinely vaccinate

for Hib (Haemophilus influenza type ,

[8][9][10][11] Sweden is a country where 99% of

the target population was vaccinated for Hib in

2001.

[<http://www.whale.to/vaccines/hoffman.html#12>12]

Sweden also has low peanut consumption, yet this

low consumption has not prevented peanut allergy

in that country. Van Odijk et al concluded that

" the reaction pattern to peanuts in Sweden is

similar to that in many other countries despite a

reported steady and low consumption. "

[<http://www.whale.to/vaccines/hoffman.html#13>13]

It appears that countries that introduced Hib

vaccination in their infant schedules have high

rates of peanut allergy regardless of consumption.

Children can react to peanut allergens on their

first exposure.

[<http://www.whale.to/vaccines/hoffman.html#14>14]

Sensitization to peanut can occur during

breastfeeding.

[<http://www.whale.to/vaccines/hoffman.html#15>15]

Yet sensitization through breast milk cannot

possibly explain the increase in peanut

anaphylaxis as mothers worldwide have been eating

peanuts while breastfeeding for

decades. Zimmerman et al (1989) found in their

study that " these results suggest that highly

atopic infants are at special risk for

sensitization to peanut, even when they have

never received peanut..... "

[<http://www.whale.to/vaccines/hoffman.html#16>16]

K.L. Capozza, Health Scout News, in an article

entitled " Study Acquits Peanuts in Allergic

Reaction " described a recent study by Turncanu et

al who took three types of children, those with

peanut allergies, those that " outgrew " their

allergy and those who have no peanut

allergy. Capozza describes how " after magnifying

these immune cells, or T-cells, the researchers

observed that the T-cells of allergic patients

became excited after exposure to peanut. Once

the T-cells react to the peanut extract, a

cascade of allergic responses ensue, from a skin

rash to labored breathing. " He describes how

" the research shows, the condition stems from a

person's abnormal immune response. "

[<http://www.whale.to/vaccines/hoffman.html#17>17][<http://www.whale.to/vaccines\

/hoffman.html#18>18]

What has happened to peanut allergic children to

cause their T-cells, as Capozza described to

become 'excited' to the extent that with some

children just being in the same room with peanuts

can cause a reaction? Could vaccines be the cause?

Dr. Philip Incao aptly describes how vaccines

affect the immune response in his article " How

Vaccines Work. " " So the trick of a vaccination

is to stimulate the immune system just enough so

that it makes antibodies and 'remembers' the

disease antigen but not so much that it provokes

an acute inflammatory response by the cellular

immune system and makes us sick with the disease

we’re trying to prevent! Thus a vaccination works

by stimulating very much the antibody production

(Th2) and by stimulating very little or not at

all the digesting and discharging function of the

cellular immune system (Th1). Vaccine antigens

are designed to be 'unprovocative' or

'indigestible' for the cellular immune system

(Th1) and highly stimulating for the

antibody-mediated humoral immune system (Th2).

Perhaps it is not difficult to see then why the

repeated use of vaccinations would tend to shift

the functional balance of the immune system

toward the antibody-producing side (Th2) and away

from the acute inflammatory discharging side (the

cell-mediated side or Th1). " [<http://www.whale.to/vaccines/hoffman.html#19>19]

Atopic disorders are the cluster of 3 related

disorders, allergies, asthma, and eczema with

anaphylaxis being the most severe form of

allergic reaction. Atopic disorders are pervasive

and raise the alert that the immune system has

been sensitized and has shifted away from its

normal functioning TH1 mode into a chronically reactive TH2 mode.

Anaphylaxis to foods in young children seemed to

be rare prior to the introduction of the first

Hib polysaccharide vaccine in 1987 (Canada) to a

schedule already containing vaccines for

diphtheria, pertussis, tetanus and polio,

measles, mumps and rubella. Beginning in 1992,

many infants were given various Hib vaccines

concurrently with DPT-P, and beginning in 1994 in

a combined 5 in 1 vaccine called Penta. In 1997

the acellular pertussis 5 in 1 vaccine Pentacel

was introduced. The cover story in the September

2000 issue of Professionally Speaking, the

magazine of the Ontario College of Teachers was

" An Abnormal Response to Normal Things. " The

article begins with " Teachers have to be aware

that allergies can kill. A growing number of

children are at risk - and a well prepared

teacher can make all the difference. " The article

explains that " About a decade ago, the sudden

surge in highly allergic children entering school

systems across the province caught many educators

off guard. " Doesn't this " surge " correspond to

the introduction of the Hib vaccine?

In Ontario, the Hepatitis B vaccination series is

given in Grade 7, not at birth, so the Hepatitis

B vaccine would not have an impact on the numbers

of young children with peanut and nut

anaphylaxis, yet it remains to be seen if this

vaccine may be implicated in increased numbers of

teenagers becoming anaphylactic.

Children in Ontario aged 18 and younger could

have received up to five different types of Hib

vaccines. The first Hib vaccine, introduced in

1987, was a one dose polysaccharide Hib vaccine

for children age 2 and up. Infant immune systems

did not mount an immune response to the

polysaccharide vaccine, so vaccine researchers

developed conjugate vaccines to " trick " the

infant immune system into recognizing the Hib antibody.

Conjugate vaccines, according to a U.S. National

Institute of Health website, link " a 'weak'

polysaccharide to a protein easily recognized by

the immature immune

system. " [<http://www.whale.to/vaccines/hoffman.html#20>20]

The Hib conjugate vaccines results in " greatly

enhanced antibody responses and establishment of

immunological memory " , and the four conjugate Hib

vaccines given to children " differ in a number of

ways, including the protein carrier,

polysaccharide size and types of diluent and

preservative.

[<http://www.whale.to/vaccines/hoffman.html#21>21]

Who’s to say that this 'protein easily recognized

by the immature immune system' won't " trick " the

infants body into thinking that food eaten at the

same time as the vaccine is an invader worthy of

a 'greatly enhanced antibody response'?

Although Hib vaccines have been credited as being

a public health miracle, the road to the

development and implementation of these vaccines

seems to have been anything but smooth. The lack

of knowledge about this vaccine's interactions

with the immune system is frightening. Here are just a few examples:

One of the most shocking studies I came across

was Nicol et al concluding in 2002, a decade

after infants were given this vaccine, that

1/10th of the dose of Haemophilus influenzae type

B conjugate vaccine (PRP-T) was as immunogenic

and safe as the full

dose.[<http://www.whale.to/vaccines/hoffman.html#22>22]

Considering that the Hib vaccine results in

" greatly enhanced antibody responses " , does this

mean that children have been receiving 10 times

the amount of Hib vaccine that would be necessary

to provide that antibody response, thus creating

a hypersensitivity to proteins encountered during

and after vaccination in children, especially

children with a tendency toward allergy?

Also shocking was Pichichero (2000) in his paper

on new combination vaccines, describes.... " the

protective threshold for conjugated PRP [Hib]

vaccines is not known..... " [<http://www.whale.to/vaccines/hoffman.html#23>23]

Pabst and Spady (1990) studied infants immunized

at 2, 4, and 6 months with conjugate Haemophilus

influenzae type B vaccine. They found that

" antibody levels were significantly higher in the

breast-fed (57 infants) than in the formula-fed

group (24 infants) at 7 months and at 12 months "

and that breastfeeding " enhances the active

immune response in the first year of life, and

therefore the feeding method must be taken into

account in the evaluation of vaccine studies in

infants. "

[<http://www.whale.to/vaccines/hoffman.html#24>24]

Many anaphylactic children were breastfed as

infants, which would have boosted this immune

response even more! Breast fed and bottle fed

babies receive the same doses of vaccines, even

though sixteen years ago the above authors found

that feeding methods should be evaluated in

vaccine studies! This study was later challenged

in Scheifele et al's letter to The Lancet in 1992

in which they conclude that " It seems that the

earlier conclusions were incorrect and that

breastfeeding does not enhance responses to

haemophilus b conjugate vaccines, at least when

assessed on completion of the primary series.”

[<http://www.whale.to/vaccines/hoffman.html#25>25].

The Hib vaccine that Pabst and Spady studied was

the CRM 197 mutant diphtheria toxin conjugate

vaccine. Scheifele's study used the PRP-T

(tetanus conjugate) vaccine. If Dr. Scheifele

was going to discount Pabst and Spady's results

why didn't he use the same vaccine? Oh, well,

full speed ahead! One shot must fit all,

breastfed or not! We must maintain the status quo!

Numerous studies have sounded warnings regarding

combination or concurrently administered vaccines

including Hib. Here are just three examples:

Even as late as May 2000, Rennels et al concluded

that " In this trial concurrent IPV [inactivated

polio vaccine] appeared to interfere with the

anti-PRP [Hib] response to DTaP/Hib vaccine

suggesting that introduction of new vaccines may

require evaluation of immune responses to all

concurrently administered

vaccines. " [<http://www.whale.to/vaccines/hoffman.html#26>26]

The 2004 American Academy of Pediatrics Annual

Meeting report on New Combination Vaccines for

Childhood Diseases raised red flags about

combination vaccines, saying " However, the

reactogenicity and potential side effects of the

combined antigens have not yet been determined.

Since there is the potential for physical and

chemical interaction among the vaccine components

and the buffers and preservatives, the

immunogenicity of each component needs to be

addressed to determine whether these are similar

to and as effective as the components given

individually. " [<http://www.whale.to/vaccines/hoffman.html#27>27]

Redhead K et al (1994) in a very frightening

study, state: " However, combination with the Hib

vaccine comprising polysaccharide conjugated to

tetanus toxoid had dramatic effects on tetanus

potency and immunogenicity when assayed in

mice. This combination resulted in a five-fold

potentiation of the tetanus potency and a

similarly large increase in the antibody

responses to tetanus toxin and toxoid. The level

of the antibody response to the Hib

polysaccharide in this vaccine was also elevated,

more than 20-fold, as a result of the

combination. " [<http://www.whale.to/vaccines/hoffman.html#28>28]

Shouldn't these studies be raising red

flags? Antibody responses to Hib elevated more

than 20 fold? Reactogenicity and potential side

effects of combined antigens not yet

determined? I haven't seen any studies that look

at the IgE (allergy) levels post vaccination.

Surely it's not much of a stretch to think that

infant’s immune systems might be hypersensitive after receiving these vaccines!

Now let's look at what vaccines could be cross

reacting with peanut. When researchers study

allergies and cross reactive proteins they

determine the various molecular weights of the

allergen. Foods with the same molecular weight

can cause cross reactions in allergic

persons. And it's not just foods cross

reacting. In a January 22, 2002 news release,

the American Academy of Allergy, Asthma and

Immunology provided a list of the most common

foods that are cross reactive to latex including

banana, avocado, chestnut, kiwi and celery. They

describe, " The immune system recognizes the

'cross-reactive' protein, symptoms manifest and

an adverse reaction occurs. An active immune

system may not distinguish the difference between

the similar looking proteins, so an allergy to

one member of the food family may result in the

person being allergic to all the members of the same group. "

I have often wondered why vaccines with latex

stoppers have not been considered as a potential

cause of the tremendous rise in latex allergy

among highly vaccinated health care

workers. Primeau et al (2001) found that

" Natural rubber vial closures released allergenic

latex proteins into the tested solutions in

direct contact during storage in sufficient

quantities to elicit positive intradermal skin

reactions in some individuals with LA. These data

support a recommendation to eliminate natural

rubber from closures of pharmaceutical vials. "

[<http://www.whale.to/vaccines/hoffman.html#29>29]

There are many vaccines that have latex stoppers

that may be sensitizing people. Health Canada

does not have a list, but the state of

Massachusetts provides information regarding

which vaccines contain latex or thimerosal

[<http://www.whale.to/vaccines/hoffman.html#30>30]

If people with latex allergy can have cross

reactions with foods, then one must ask if

vaccine ingredients can cause cross reaction with

foods having the same molecular weight?

Using PubMed I looked for molecular weights of

ingredients in infant vaccines and some of the

most common allergenic foods in small

children. Measured in kilodaltons (kDa), the

most striking molecular weight that could cross

react is 50 kDa contained in the following: Hib,

Diphtheria, Tetanus, Neisseria Meningitidis,

peanut, almond, soybean and cashew. The

molecular weight 43 kDa is present in both Hib

and peanut. 20 kDa is present in both Hib and

peanut. 37 kDa is present in both Hib and

Almond. 49 kDa is present in Hib and Mango.

Molecular weight of proteins in

vaccines Molecular weights

of food proteins triggering reactions

- Haemophilus influenzae type B

(Hib) - Peanut

50, 49, 43, 37, 20,

16, kDa 50, 43, 20, 16 kDa

- Diphtheria - 50,

27 kDa

- Almond 50, 37 kDa

(also used as carrier protein in some Hib vaccines)

-

Soybean 50,16.5 kDa

- Tetanus - 50 kDa

(also used as carrier protein in some Hib

vaccines) - Cashew 50 kDa

- Neisseria meningitidis - 50

kDa - Mango 49 kDa

(also used as carrier protein in some Hib vaccines)

References:

Hib

[<http://www.whale.to/vaccines/hoffman.html#31>31-39]

Diphtheria

[<http://www.whale.to/vaccines/hoffman.html#40>40-41]

Tetanus

[<http://www.whale.to/vaccines/hoffman.html#42>42-45]

Neisseria meningitides [<http://www.whale.to/vaccines/hoffman.html#46>46]

Peanut

[<http://www.whale.to/vaccines/hoffman.html#47>47-50]

Almond

[<http://www.whale.to/vaccines/hoffman.html#51>51-53]

Soybean

[<http://www.whale.to/vaccines/hoffman.html#47>47]

Cashew

[<http://www.whale.to/vaccines/hoffman.html#54>54]

Mango [<http://www.whale.to/vaccines/hoffman.html#55>55]

So the first vaccines my child received, DPT-P +

Hib contained Diphtheria (50 kDa), Tetanus (50

kDa), Pertussis, Polio, Mutant Diphtheria carrier

protein in the Hibtitre vaccine (50 kDa) plus Hib

(50 kDa). Is there any wonder, when my son

encountered peanut (50 kDa), Almond (50 kda) and

Cashew (50 kDa) via breastmilk while his body's

immune system was processing the vaccines, that

his body went on extreme high alert for anything

with a 50 kDa molecular weight? Granoff and

Munson (1986) describe when conjugate vaccines

are prepared, " new antigenic determinants are

formed.....but their presence raises the

possibility that these neoantigens may elicit

antibodies cross-reactive with human antigens. "

[<http://www.whale.to/vaccines/hoffman.html#31>31]

Cross reactive proteins can be very dangerous for

people with allergies. I know a young girl who

had vomited after eating cashews as a toddler and

was never given nuts after that time. Not long

after her school age boosters of DTaP-Polio and

MMR she was given a piece of mango and had to be

rushed to the hospital. It was only after some

investigating that the parents realized that

mango and cashew can cross react. This girl's

mother happens to love mango, and while she would

not bring the fruit into her home she decided it

was safe to eat some at her workplace for lunch,

afterward carefully washing her hands. Upon

arriving home several hours later, the mother

kissed the little girl on the cheek. Swelling

and hives ensued, and even with anti-histamines

it was days before the child's reaction

subsided. From a kiss on the cheek! Another

child with a nut allergy had an anaphylactic

reaction to a fruit juice containing mango, again

the parents being unaware of the cashew/mango

cross reaction. These bizarre immune responses

put children at risk of dying every day.

Stories like these aren't too surprising once you

look at the medical literature where the link

between vaccination and anaphylaxis seems crystal

clear in animal studies dating back as far as

1952. Saul Malkiel, Betty J. Hargis and Leon S.

Kind completed numerous studies where vaccinated

animals became anaphylactic, many funded in part

by the National Institute of Health. Imagine

reading, from 1959, " We have repeatedly observed

in experiments on mice that a consequence of the

administration of Hemophilus pertussis phase I

organisms given in conjunction with a protein

antigen is the enhancement of anaphylactic

sensitization to the foreign protein

antigen. " [<http://www.whale.to/vaccines/hoffman.html#56>56]

And we have allergists telling us that skin

creams cause anaphylaxis? And I was furious when

I read Kind and Roesner (1959), " It is now well

known that mice inoculated with Hemophilus

pertussis vaccine develop enhanced sensitivity to

lethal effects of histamine, serotonin,

endotoxin, peptone and anaphylactic shock. The

ensuing data will demonstrate that

pertussis-inoculated mice can also be killed with

doses of water soluble extract of pollen rye

grass which are not lethal to uninoculated

animals. "

[<http://www.whale.to/vaccines/hoffman.html#57>57]

Kind and s (1964) in the Journal Nature,

state " It is now well known that mice injected

with Bordetella pertussis vaccine plus an antigen

will produce more antibodies to that antigen than

mice injected with antigen alone. "

[<http://www.whale.to/vaccines/hoffman.html#58>58]

Couldn’t the same apply to babies?

And how do researchers make anaphylactic animal

models? They vaccinate the animals! Countless

studies show anaphylaxis being induced in animals

by using toxins and adjuvants used in human

vaccines. Here is one example from hundreds:

Helm et al in Environmental Health Perspectives

article " Nonmurine Animal Models of Food Allergy "

discuss ways to create animal models of human

food allergy.

[<http://www.whale.to/vaccines/hoffman.html#59>59]

Animal models are discussed extensively,

including " the use of adjuvants (natural or

artificial--alum, cholera toxin, Bordetella

pertussis, and carrageenan are known

IgE-selective adjuvants) " in those animal

models. They go on to describe, " In the atopic

dog model for food allergy (Ermel et al. 1997),

newborn pups (day 1) were subcutaneously injected

in the axillas with 1 µg of cow's milk, beef,

ragweed, and wheat extracts in alum. Food antigen

was again administered on days 22, 29, 50, 78,

and 85. At ages 3, 7, and 11 weeks, all pups were

vaccinated with attenuated distemper-hepatitis

vaccine...Immunized pups responded with

allergen-specific IgE by week 3 and peaked at

week 26 of age...All clinical manifestations are

consistent with infant, adolescent, and adult food allergy in humans. "

It has been shown repeatedly that vaccination can

cause sensitization, including anaphylaxis, to

vaccine ingredients. et al (2000) discuss

a 4 month old baby's anaphylactic reaction to the

CRM 197 protein in the Hib vaccine.

[<http://www.whale.to/vaccines/hoffman.html#60>60]

As far back as 1940 Cooke et al noted that " The

real object of this presentation is to acquaint

the medical profession with proof of the fact

that sensitivity can be induced as a result of

the present procedures of active immunization to

tetanus. " [61] Cooke et al also mentioned Neill

et all (1929) noted hypersensitivity to diphtheria bacilli. [62]

Patrizi et al (1999) and Osawa et al (1991) noted

allergic sensitization to thimerosal.

[63][64] -Munoz et al described allergic

sensitization to tetanus and diphtheria toxoids

simultaneously.

[<http://www.whale.to/vaccines/hoffman.html#65>65]

Kumagai et al (2002) found " gelatin-specific

cell-mediated immunity develops in subjects

inoculated with gelatin containing DTaP vaccine "

and that the specific cellular immune responses

persisted for more than 3 years.

[<http://www.whale.to/vaccines/hoffman.html#66>66]

Sakaguchi et al (1996) concluded that " We

reconfirmed a strong relationship between

systemic immediate-type allergic reactions

including anaphylaxis, to vaccines and the

presence of specific IgE to gelatin. "

[<http://www.whale.to/vaccines/hoffman.html#67>67]

Nakayama et al (1999) found that " DTaP vaccine

may have a causal relationship to the development

of this gelatin allergy. " [<http://www.whale.to/vaccines/hoffman.html#68>68]

So, if the medical literature shows anaphylactic

sensitization to vaccine ingredients, then is it

much of a leap to think that protein fragments in

those vaccines could be causing cross reactive

sensitization with antigens with the same antigenic determinant?

A key piece of the hypersensitivity puzzle is the

vaccine adjuvant aluminum according to New

Zealand researcher and author

. states that “Aluminium is put

into vaccines, because without it, the body will

not react to weak strains of antigens. Aluminium

is highly reactive, and is a Th2 ‘skewer’. This

is the whole reason why aluminum is added to

vaccines. And Aluminium will ALWAYS create IGE,

and if this happens in the presence of proteins

from vaccines or food antigens in the body, then

there is a high chance of allergy

developing.” She points out the study by

Yamanishi et al (2003) who immunized mice against

Kunitz-type soybean trypsin inhibitor (KSTI) and

concluded that...“we demonstrated that,

regardless of the inability to adsorb KSTI, alum

exerted its adjuvant activity only when it was

co-injected with the antigen. These results

showed that some biochemical effect, other than

adsorptive activity, to enhance the production of

the antigen-specific IgE resides in alum.[69]

According to , “this goes along with

evidence I have elsewhere that highlights the

observation that aluminum does not have to be

absorbed onto the antigen in order for an immune

response to be stimulated. Another thing is that

aluminum produces mostly IgE antibodies (allergic

antibodies).” Numerous studies have also shown

that aluminum is linked to allergic responses.

[<http://www.whale.to/vaccines/hoffman.html#70>70]

VRAN researcher Fletcher notes the

importance of digestion (which can be affected by

antibiotic use) in the development of asthma and

allergies. Vaccinations are routinely given to

infants and children even though they may have

been given antibiotics for a recent health issue,

certainly affecting their immune response to the

vaccine. Untersmayr et al (2006) found “for the

first time the important gate-keeping function of

gastric digestion, both in the sensitization and

the effector phases of food

allergy.”[<http://www.whale.to/vaccines/hoffman.html#71>71]

Richet described back in his Nobel

Lecture in 1913, " all proteins, without exception

produce anaphylaxis: one had seen this with all

sera, milks, organic extracts whatsoever, all

vegetable extracts, microbial protein toxins,

yeast cells, dead microbial bodies. It would be

of more interest now to find a protein which does

not produce anaphylaxis than to find one that does. "

He then chillingly states in his conclusion, " It

does not matter much that the individual becomes

more vulnerable in this regard. There is

something more important than the salvation of

the person and that is integral preservation of

the race. In other words, to formulate the

hypothesis in somewhat abstract terms but clear

ones all the same: the life of the individual is

less important than the stability of the

species. Anaphylaxis, perhaps a sorry matter for

the individual, is necessary to the species,

often to the detriment of the individual. The

individual may perish, it does not matter. The

species must at any time keep its organic

integrity intact. Anaphylaxis defends the species

against the peril of adulteration. "

[<http://www.whale.to/vaccines/hoffman.html#1%5D>1]

How can Richet have won the Nobel Prize in 1913

for this knowledge yet the medical community

today seems to have no clue why our children are

anaphylactic? Why has medicine, to which parents

have entrusted their precious children, continued

to vaccinate for more and more diseases, knowing

that our " organic integrity " could be at

stake? May I suggest that researchers or doctors

can't see the forest for the trees, or there is one huge cover-up?

With hundreds of new vaccines in the pipeline,

how much longer can we continue to inject more

and more foreign proteins via vaccination into

human beings without eventually creating a

totally defenseless population? How many more

children will become anaphylactic, be rushed to

emergency fighting for their lives or die before something is done?

--------------------------------------

Updated July 2006 - Acknowledgments: Special

thanks to Amy and for their countless hours

in the medical library, ,

<http://users.adelphia.net/%7Ecdc/>Critical

Decisions Count, Sandy Gottstein,

<http://www.vaccinationnews.com/>www.vaccinationnews.com

and especially to Edda West,

<http://www.vran.org/>www.vran.org for believing

in " 's Story " . A big thank you to Suzanne

Brezovich, Ingri Cassel, ,

Fletcher and Edda West for input and

editing. And to my dear little , you are a

brave soul. May our Creator continue to bless and protect you.

For further information, including medical

journal articles showing a vaccine link to

anaphylaxis, please visit VRAN's webpage at

<http://www.vran.org/>www.vran.org under the heading " Anaphylaxis " .

Footnotes

[1] Richet, - Nobel Lecture Dec. 11,

1913

<http://www.nobel.se/medicine/laureates/1913/richet-lecture.html>http://www.nobe\

l.se/medicine/laureates/1913/richet-lecture.html

(April 3, 2006)

[2] Merriam Webster Medical

Dictionary

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medlineplus/mplusdictionary.html

[3] Health Canada - It's Your Health - Severe

Allergic

Reactions.

<http://www.hc-sc.gc.ca/iyh-vsv/med/allerg_e.html>http://www.hc-sc.gc.ca/iyh-vsv\

/med/allerg_e.html

(April 3, 2006)

[4] M. Carolyn Black, " The potential power of

Bill 3 - Measure aims to protect estimated 40,000

Ontario students with a life-threatening allergy

to such things as peanuts or insect stings " Toronto Star March 30, 2005

[5] Health On The Line - " Severe Allergies " -

Videocassette - Discovery Health 2002

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peanut allergenicity. J Allergy Clin Immunol 2001 June;107(6):1077-81

[7] Ewan, PW. Prevention of peanut allergy. Lancet. 1998 Jul 4;352(9121):4-5.

[8] World Health Organization. Immunization

Profile - China

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t.cfm?C=%27chn%27>http://www.who.int/immunization_monitoring/en/globalsummary/co\

untryprofileresult.cfm?C='chn'

(Feb. 17, 2006)

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and Streptococcus pneumoniae as Causes of

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Sheri Nakken, former R.N., MA, Hahnemannian Homeopath

Vaccination Information & Choice Network, Nevada City CA & Wales UK

Vaccines - http://www.wellwithin1.com/vaccine.htm

Vaccine Dangers & Homeopathy Online/email courses