Implants & Breast Feeding repost

[Guest guest]

I posted these a few weeks ago, but thought I'd post them again since the

subject is being discussed a lot.

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Abstract from The Journal of the American Medical Association:

Sclerodermalike esophageal disease in children breast-fed by mothers with

silicone breast implants

J. J. Levine and N. T. Ilowite

Division of Pediatric Gastroenterology, Schneider Children's Hospital, Long

Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde

Park, NY 11042.

OBJECTIVE--To determine whether breast-fed children of mothers with silicone

implants are at increased risk for the development of sclerodermalike

esophageal involvement compared with children not exposed to silicone

implants. DESIGN--Case-series [corrected]. SETTING--Referral-based pediatric

gastroenterology clinic. PATIENTS--Eleven children (mean age, 6.0 years;

range, 1.5 to 13 years; six boys and five girls) referred for abdominal pain

who were born to mothers who had silicone breast implants (eight breast-fed

children and three bottle-fed) were compared with 17 patients (mean age,

10.7 years; range, 2 to 18 years; 11 boys and six girls) with abdominal pain

who were not exposed to silicone implants. METHODS--All children underwent

esophageal manometry and upper intestinal endoscopy with esophageal biopsy

and were tested for antinuclear antibody and autoantibodies to Scl-70,

centromere, ribonucleoprotein, Sm, Ro, La, and phospholipid. RESULTS--Six of

the eight breast-fed children from mothers with silicone implants had

significantly abnormal esophageal motility with nearly absent peristalsis in

the distal two thirds of the esophagus and decreased lower sphincter

pressure. Upper esophageal pressures and motility were normal. Compared with

controls, the breast-fed children had significantly decreased lower

sphincter pressure and abnormal esophageal wave propagation. These

manometric abnormalities were not seen in the three bottle-fed children.

There was no difference in the expression of autoantibodies in the

breast-fed children compared with the bottle-fed children or controls.

CONCLUSIONS--A relationship appears to exist between breast-feeding by

mothers with silicone implants and abnormal esophageal motility. Studies

evaluating larger numbers of children are needed to determine the extent of

the risk. Bartel, D.R. To the Editor--Sclerodermalike esophageal disease in

children of mothers with silicone breast implants. JAMA 1994 (September 14);

272(10):767.

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Abstracts from Medline

Title

Increased urinary NO3(-) + NO2- and neopterin excretion in children breast

fed by mothers with silicone breast implants: evidence for macrophage

activation.

Author

Levine JJ; Ilowite NT; Pettei MJ; Trachtman H

Address

Division of Gastroenterology and Nutrition,

Schneider Children's Hospital.

Long Island Jewish Medical Center

New Hyde Park, NY 11040, USA.

Source

J Rheumatol, 1996 Jun, 23:6, 1083-7

Abstract

OBJECTIVE: To determine whether children breast fed by mothers with silicone

implants (BFSI) have increased urinary excretion of nitric oxide (NO)

metabolites and neopterin, whether these are associated with esophageal

dysmotility, and whether in vitro incubation of macrophages with silicone

increases NO synthesis.

METHODS: In a case-control study based on laboratory investigation, 38 BFSI

children (17 male, 21 female, mean age 7.1 +/- 3.6 years, range 0.5-16.5)

were compared with 30 controls (14 male, 16 female, mean age 8.4 +/- 3.5

years, range 2.5-17). Urinary NO was quantitated using the Griess reaction.

Urinary neopterin was determined by radioimmunoassay. Murine macrophages

were cultured with or without silicone and NO production assayed.

RESULTS: Urinary NO and neopterin were significantly increased in BFSI

children compared with controls. There was a significant inverse

relationship between urinary neopterin excretion and the severity of

esophageal dysfunction. In vitro nitrite production was nearly 60% higher in

macrophages grown on silicone compared to other growth conditions.

CONCLUSION: BFSI children have evidence of macrophage activation and this is

associated with esophageal dysmotility. In vitro data support the proposal

that silicone exposure causes macrophage activation.

Language of Publication: English

Unique Identifier : 96375855

Publication Type JOURNAL ARTICLE

ISSN 0315-162X

Country of Publication CANADA

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Title

Esophageal dysmotility in children breast-fed by mothers with silicone

breast implants. Long-term follow-up and response to treatment.

Author Levine JJ; Trachtman H; Gold DM; Pettei MJ

Address

Division of Gastroenterology and Nutrition, Schneider Children's Hospital,

Albert Einstein College of Medicine,

New Hyde Park, New York 11040, USA.

Source

Dig Dis Sci, 1996 Aug, 41:8, 1600-3

Abstract Our aims were to determine the long-term clinical and manometric

follow-up of 11 children with previously documented esophageal dysmotility,

who had been breast-fed by mothers with silicone breast implants, their

response to prokinetic agents, and to analyze changes in macrophage

activation. Seven of 11 children had subjective clinical improvement.

Weight/ height ratios remained the same or improved in 9/11. Biopsies at

follow-up endoscopy were either normal or demonstrated mild esophagitis in

8/10. LES and UES pressures and percent propagation were not significantly

different at follow-up, while wave amplitude significantly increased.

Following intravenous metoclopramide, LES pressure, percent propagation, and

wave amplitude significantly increased while UES pressure was unchanged.

Urinary neopterin significantly decreased at follow-up, while urinary

nitrates were unchanged. Esophageal dysmotility is chronic in this group of

children, suggesting persistent autonomic nervous system dysfunction.

Prokinetic agents may be useful in long-term management. The decreasing

urinary neopterin levels suggest that, ultimately, there may be improvement

in esophageal motility.

Language of Publication: English

Unique Identifier : 96354644

Publication Type JOURNAL ARTICLE

ISSN 0163-2116

Country of Publication UNITED STATES

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this is part of an article from the FDA's site:

Breast-Feeding Best Bet for Babies

by D.

When Formula's Necessary

....there is some concern that silicone may harm the baby. Some small studies

have suggested a link between breast-feeding with implants and later

development of problems with the child's esophagus. Further studies are

needed in this area. But if a woman with implants wants to breast-feed, she

should first discuss the potential benefits and risks with her child's

doctor.

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this is part of an article from Mentor's site:

Can I Breast-Feed with Breast Implants?

Breast implants may interfere with your ability to successfully breast-feed.

With respect to the ability to successfully breast-feed after breast

implantation, one study reported up to 64% of women with implants who were

unable to breast feed compared to 7% without implants. The periareolar

incision site may significantly reduce the ability to successfully

breast-feed.

At this time it is not known if a small amount of silicone may diffuse (pass

through) from the saline-filled breast implant silicone shell and may find

its way into breast milk. If this occurs, it is not known what effect it may

have on the nursing infant. There are no current methods for detecting

silicone levels in breast milk