Re: Meningitis - more info on HIB vax, then other strains appear

[Guest guest]

Thanks!!!!!

In a message dated 9/15/2008 5:37:50 A.M. Central Daylight Time,

vaccineinfo@... writes:

The Perilous Haemophilus or is it.....pneumonia -

_http://www.vaccinathttp://www.http://wwwhttp_

(http://www.vaccination.org.uk/m/butler7.html)

" The sentences might also mean that universal Haemophilus vaccination

resulted in a decrease in Haemophilus diseases including meningitis

and that the void was filled by an increase in pneumococcal diseases

caused by antibiotic resistant pneumococci. If this is the

explanation, then solution of one problem has given rise to another

and this new problem is difficult to treat with available antibiotics

which gives rise to a new need: antibiotics that are active against

pneumococcal strains that invade difficult to treat sites like the

meninges and heart valves. "

" This apparent one step forward-one step backward situation is

reminiscent of similar problems that accompanied early use in the

1960's of inactivated adenovirus vaccines to prevent respiratory

diseases caused by adenovirus types 3, 4 and 7. The vaccines were

highly effective in preventing disease caused by these types, but not

effective in preventing respiratory diseases caused by the other 40

or more adenoviruses that moved in to replace types 3, 4 and 7. Soon

after this situation was recognised, use of adenovirus vaccines,

except for use in military personnel, was abandoned. It might be well

when assessing the overall value of the current program of universal

Haemophilus vaccination, to keep in mind the earlier adenovirus

vaccine experience. "

" " Knowledge of past events is of value if it is of use in predicting

future events. Thus in the 3 April issue of LANCET is a paper

" population- " population-<WBR>based study of Non-typable Haemop

Invasive Disease in children and Neonates " . It reports " Infections

due to (non-capsulated) H influenzae strains are, after the

implementation of Hib vaccines, likely to persist and represent a

substantial proportion of the serious infections caused by this

species... Furthermore, the relative importance of such organisms may

increase because of the general introduction of type b polysaccharide

vaccines, which will greatly diminish invasive Hib disease, but not

systemic infection caused by NST of H influenzae of other capsular types.'

**********

Appearance of new strains after vax with HIB vax

_http://bmj.bmjjournhttp://bmj.bhttp://bmj.bmhttp://bmhtt_

(http://bmj.bmjjournals.com/cgi/content/full/312/7024/160)

increase in non-type b strains - they like to explain it away - but

this is what we have seen - decrease in one type and increase in

another - nature abhors a vacuum?

********

" there was a relative increase of nontypeable strains from 3 to 6.6%

(P = 0.27). "

_http://www.ncbi.http://www.nhttp://www.nchttp://www.ncb & <WBR>cmd=Ret & <WBR>lis

t_<WBR>li & dopt=dopt=<WB_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Retrieve & list_uids=\

8904414 & dopt=Abstract)

_http://www.ncbi.http://www.nhttp://www.nchttp://www.ncb & <WBR>cmd=Ret & <WBR>lis

t_<WBR>li & dopt=dopt=<WB_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Retrieve & list_uids=\

8589168 & dopt=Abstract)

Increase in other strains - an increase in infection due to non-type

b serotypes of H. influenzae

_http://www.ncbi.http://www.nhttp://www.nchttp://www.ncb & <WBR>cmd=Ret & <WBR>lis

t_<WBR>l & dopt=dopt=<WB_ (http://www.ncbi.nlm.nih.gov/ent

rez/query.fcgi?db=PubMed & cmd=Retrieve & list_uids=310538 & dopt=Abstract)

" " Serious infections caused by other H. influenzae types will

continue to occur sporadically and may increase in frequency when an

effective vaccine against type b is widely used in infants. " "

_http://www.ncbi.http://www.nhttp://www.nchttp://www.ncb & <WBR>cmd=Ret & <WBR>lis

t_<WBR>li & dopt=dopt=<WB_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Retrieve & list_uids=\

9568952 & dopt=Abstract)

J Paediatr Child Health. 1998 Feb;34(1):95-J Paediatr Child Health. 1

Meningitis due to Haemophilus influenzae type f.

_http://www.ncbi.http://www.nhttp://www.nchttp://www.ncb & <WBR>cmd=Ret & <WBR>lis

t_<WBR>li & dopt=dopt=<WB_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Retrieve & list_uids=\

8783712 & dopt=Abstract)

" Again, increase in other types. " With the decline in the rate of

infections caused by Haemophilus influenzae serotype b, H. influenzae

serotype f (Hif) is becoming a relatively important cause of invasive

disease due to H. influenzae. " d

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