Asthma & autism: not especially

[Guest guest]

As a homeopath, I would look at this from a homeopathic perspective

When a person is too ill from a deeper, stronger

disease, they don't become ill from another.

Like those with Alzheimer's or mental illness -

they rarely even get sick with colds or other things

The stronger disease is what is evident

If something else comes along or develops that is

stronger, those symptoms will be in evidence

Sheri

From binstock <binstock@...>

> " This study suggests allergic features based on

>history, skin tests, and serum IgE levels are

>not frequent in young autistic children despite

>family history. This discrepancy between

>predisposition and manifestation might imply

>immunological factors or environmental conditions. " (2)

> " Clinical features of the ASD test group were

>not associated with atopy, asthma, FA, or PID in our study... " (3)

>

>2: Eur J Paediatr Neurol. 2008 Nov;12(6):476-9.

>Epub 2008 Feb

>12.<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & DbFrom=pubmed & Cmd=Link & L\

inkName=pubmed_pubmed & LinkReadableName=Related%20Articles & IdsFromResult=18272414\

& ordinalpos=2 & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAb\

stract>Related

>Articles, Links

><http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048 & itool=Abstract-de\

f & uid=18272414 & db=pubmed & url=http://linkinghub.elsevier.com/retrieve/pii/S1090-3\

798%2808%2900002-0>

>Click here to read

>

>Atopic features in early childhood autism.

>

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Bakkalog\

lu%20B%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pub\

med_RVAbstract>Bakkaloglu

>B,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Anlar%20\

B%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_R\

VAbstract>Anlar

>B,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Anlar%20\

FY%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_\

RVAbstract>Anlar

>FY,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Oktem%20\

F%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_R\

VAbstract>Oktem

>F,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Pehlivan\

t%C3%BCrk%20B%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa\

nel.Pubmed_RVAbstract>Pehlivantürk

>B,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Unal%20F\

%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RV\

Abstract>Unal

>F,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Ozbesler\

%20C%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubme\

d_RVAbstract>Ozbesler

>C,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22G%C3%B6k\

ler%20B%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pu\

bmed_RVAbstract>Gökler

>B.

>Department of Child Psychiatry, Faculty of

>Medicine, Hacettepe University, Pediatric Neurology, Ankara 06100, Turkey.

>BACKGROUND: Autism is a developmental disorder

>of unknown etiology. Sensitivity to dietary and

>environmental antigens has been considered in

>its pathogenesis. AIM: To examine immediate

>hypersensitivity in early childhood autism.

>METHODS: We investigated 30 autistic children

>(23 boys, seven girls 2-4 years old) for atopic

>history, serum IgG, IgA, IgM, IgE levels, and

>skin prick tests (SPT) with 12 common antigens.

>RESULTS: Nine/30 autistic children (30%) and

>1/39 (2.5%) age-matched neurological controls

>from the same hospital had a family history

>suggestive of atopy (p<0.005). No patient in the

>autism and 28% in control group had symptoms of

>respiratory allergy (wheezing or asthma)

>(p<0.005), and 6/30 (20%) autistic vs. 7/39

>(17%) control children had history suggesting

>other allergic disorders (p=ns). Eleven/23

>(47.8%) autistic children had at least one

>positive skin test, similar to age-matched

>population controls. Serum IgG, IgA, and IgM

>levels were within age-appropriate limits. Serum

>IgE was elevated in four patients (13.3%).

>Specific IgE levels were negative in four cases

>with multiple SPT positivity. CONCLUSIONS: This

>study suggests allergic features based on

>history, skin tests, and serum IgE levels are

>not frequent in young autistic children despite

>family history. This discrepancy between

>predisposition and manifestation might imply

>immunological factors or environmental conditions.

>PMID: 18272414 [PubMed - in process]

>

>----------

>3: J Neuroinflammation. 2008 Nov 21;5(1):52.

>[Epub ahead of

>print]<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & DbFrom=pubmed & Cmd=Lin\

k & LinkName=pubmed_pubmed & LinkReadableName=Related%20Articles & IdsFromResult=19025\

588 & ordinalpos=3 & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_R\

VAbstract>Related

>Articles, Links

><http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3196 & itool=Abstract-de\

f & uid=19025588 & db=pubmed & url=http://www.jneuroinflammation.com/content/5/1/52>

>Click here to read

>

>Impact of innate immunity in a subset of

>children with autism spectrum disorders: a case control study.

>

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Jyonouch\

i%20H%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubm\

ed_RVAbstract>Jyonouchi

>H,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Geng%20L\

%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RV\

Abstract>Geng

>L,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Cushing-\

Ruby%20A%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.P\

ubmed_RVAbstract>Cushing-Ruby

>A,

><http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Quraishi\

%20H%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubme\

d_RVAbstract>Quraishi

>H.

>ABSTRACT: BACKGROUND: Among patients with autism

>spectrum disorders (ASD) evaluated in our

>clinic, there appears to be a subset that can be

>clinically distinguished from other ASD children

>because of frequent infections (usually viral)

>accompanied by worsening behavioural symptoms

>and/or loss/decrease in acquired skills. This

>study assessed whether these clinical features

>of this ASD subset are associated with atopy,

>asthma, food allergy (FA), primary

>immunodeficiency (PID), or innate immune

>responses important in viral infections.

>METHODS: This study included the ASD children

>described above (ASD test, N=26) and the

>following controls: ASD controls (N=107),

>non-ASD controls with FA (N=24), non-ASD

>controls with chronic rhinosinusitis/recurrent

>otitis media (CRS/ROM; N=38), and normal

>controls (N=43). We assessed prevalence of

>atopy, asthma, FA, CRS/ROM, and PID. Innate

>immune responses were assessed by measuring

>production of proinflammatory and

>counter-regulatory cytokines by peripheral blood

>mononuclear cells (PBMCs) in response to

>agonists of Toll-like receptors (TLRs), with or

>without pre-treatment of lipopolysaccharide

>(LPS), a TLR4 agonist. RESULTS: Non-IgE mediated

>FA was equally prevalent in both ASD test and

>ASD control groups, occurring at higher

>frequency than in the non-ASD controls. Allergic

>rhinitis, atopic/non-atopic asthma, and atopic

>dermatitis were equally prevalent among the

>study groups except for the CRS/ROM group in

>which non-atopic asthma was more prevalent

>(52.6%). CRS/ROM and specific polysaccharide

>antibody deficiency (SPAD) were more prevalent

>in the ASD test group than in the ASD control,

>FA, and normal control groups: 23.1% vs. <5% for

>CRS/ROS and 19.2% vs. <1% for SPAD. However,

>CRS/ROM patients had the highest prevalence of

>SPAD (34.2%). When compared to ASD and normal

>case controls, PBMCs from 19 non-SPAD, ASD test

>group children produced: 1) less IL-1beta with a

>TLR7/8 agonist, less IL-10 with a TLR2/6

>agonist, and more IL-23 with a TLR4 agonist

>without LPS pre-treatment, and 2) less IL-1beta

>with TLR4/7/8 agonists with LPS pre-treatment.

>These are cytokines associated with the

>neuro-immune network. CONCLUSIONS: Clinical

>features of the ASD test group were not

>associated with atopy, asthma, FA, or PID in our

>study but may be associated with altered TLR

>responses mediating neuro-immune interactions.

>

>PMID: 19025588