Vit.c Contraindications, Carcinogenicity & Mutagenicity

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Vit.c Contraindications, Carcinogenicity & Mutagenicity

4.3 Contraindications

Ascorbic acid is contraindicated in patients with

hyperoxaluria (Dollery, 1991) and G-6-PD deficiency

Does anyone know what G-6-PD deficiency is? Is it a liver enzyme?

7.3 Carcinogenicity

It has been reported that there is no evidence of

carcinogenicity (Dollery, 1991). However, some studies

suggest that vitamin C may amplify the carcinogenic effect of

other agents. Scwartz et al. (1993) report that L-ascorbic

acid increases the oral carcinoma size induced by

dimethylbenz(a)anthracene. Also, butylated hydroxyanisole

induced forestomach carcinogenesis in rats (Shibata et al.,

1993) and the K2CO3 induced promotion of bladder

carcinogenesis in rats (Fukushima et al., 1991) were both

amplified by the administration of ascorbic acid.

Vit. C may amplify carcinogenesis.

.5 Mutagenicity

Ascorbic acid is reported to increase the rate of

mutagenesis in cultured cells but this only occurs in

cultures with elevated levels of Cu2+ or Fe2+ . This

effect may be due to the ascorbate induced generation of

oxygen-derived free radicals. However, there is no evidence

of ascorbate induced mutagenesis in vivo (Diplock,

1995).

Here it says that Vit. C can increase mutagenesis in those with elevated

levels of copper or iron. Don't most autistics have copper overload?

http://www.inchem.org/documents/pims/pharm/ascorbic.htm