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Enzymes are catalysts in chemical reactions. The body has thousands

of them to drive metabolism, repair, and so on. There are also

enzymes that help enzymes and these are called co-enzymes. Vitamins

are co-enzymes and without a good supply of enzymes, vitamins have

little effectiveness. As we shall see, that may become a factor with

age.

Many of the body's enzymes come from the pancreas gland. These

pancreatic enzymes such as pancrease, trypsin, chymotrypsin, etc.

form the material for many other enzymes in the body in what is

called an enzyme cascade. Because among their properties and the

first noted by medical scientists (and actually the only noted

property among most of them) is to dissolve protein into amino

acids, they are called proteolytic enzymes. Proteolytic

means " protein destroying. " They are also called proteases. This

digestive function, of breaking down a steak into absorbable

molecules, is but one function of many.

Proteolytic enzymes can come from animal sources such as pancreatic

enzymes, or from plants with enzymes such as papain (from papaya,)

or bromelain (from pineapples.) There are also other sources.

Serrapeptase comes from silk worms who use it to eat their way out

of their cocoon. Nattokinase comes from fermented soy. There are

many others derived from fungus or bacteria.

Misconceptions have occurred about proteolytic enzymes. One is that

they do no more than help digestion. Related to this is the idea,

still taught in schools, that they are not absorbed into the body

but confine their activity to the digestive tract. Another false

belief is that the body has enough enzymes to do the job throughout

life.

Many studies using radioactive tracers and other techniques have

found that proteolytic enzymes are, in fact, absorbed systemically.

Clearly, nature has a reason for this.

Research has shown that the body has a fixed amount of enzymes that

are largely used up by the age of 27 to 35. After that the levels in

the body fall precipitously and with it, optimal body function

begins to decline. For example, gray hair is thought to be due to a

decline in tyrosinase. Plasminogen declines with age and that leads

to fibrosis in the arteries, the source of artherosclerosis.

Proteolytic enzymes have, in fact, several important functions in

the body besides digestion. Not all enzymes are equally efficacious

for these functions and their strengths vary among enzymes.

Fibinolytic. Fibrin is a breakdown product of fibrinogen found in

the blood stream and important in blood clotting. When there is an

injury and fibrinogen escapes the blood vessels it is used to form

scar tissue. Anyone who has had surgery knows that excess fibrin

causes problems such as adhesions. This often occurs in older

patients who do not have enough enzymes to control the fibrin. In

pathological conditions it invades organs and interferes with their

function. This condition is called fibrosis as in cystic fibrosis or

fibromyalgia or fibrocystic breast disease among many others. Some

experts believe that a slow fibrosis is a normal part of aging and

tissues and organs slowly shrink and harden over time because of

fibrosis.

In the blood vessels, fibrosis forms the basis for atherosclerosis.

Dr. Hans Nieper, the famous German medical innovator, used

serrapeptase and bromelain to dissolve deposits in the arteries and

prevent heart attacks and strokes. Excess fibrin in the blood causes

hypercoagulability or increased viscosity of the blood. In other

words, it gets thicker like ketchup. This can starve tissue of

oxygen causing the pain of fibromyalgia, or headaches. According to

several researchers, " …many chronic conditions such as attention

deficit disorder, autism and schizophrenia, as well as multiple

sclerosis, Parkinson's disease, irritable bowel, endocrine

(hypothalamic-adrenal axis-related) sleep disorder, and the type of

infertility that manifests itself in repeated miscarriages (fetal

wastage syndrome), are all related to elevated blood viscosity and

organ dysfunction caused by impeded, insufficient blood flow. "

Cancer is also associated with hypercoagulability. Among the factors

that cause this problem are excess lipoprotein (a), excess

homocysteine, excess blood fats and sugar, and excess thromboxane.

The reason that we rarely get these conditions when we are young is

because the body uses proteolytic enzymes to dissolve fibrin. After

enzyme levels decline the slow fibrosis sets in. Consuming

fibinolytic or " fibrosis busting " enzymes, especially nattokinase or

serrapeptase among others, can dissolve fibrosis over time. This may

have profound anti-aging effects. In enzyme mixtures it is the most

powerful fibrinolytic enzyme that activates the others.

Chymotrypsin, nattokinase and serrapeptase are examples.

Anti-inflammatory. Inflammation is a healthy response to injury,

marshalling the resources of the immune system to protect the body.

Recent research has shown that chronic systemic inflammation is a

major factor in many diseases such as cardiovascular disease,

cancer, diabetes, autoimmune conditions, etc. as well as the usual

inflammatory conditions such as arthritis or asthma. In many such

cases the body becomes stuck in an ever increasing, self-

perpetuating inflammation cycle where the body responds to the

danger of inflammation by creating more inflammation. Proteolytic

enzymes interfere with the inflammation cycle by stopping bradykinin

and inflammatory eicosanoids. They also ameliorate autoimmune

conditions by dissolving the circulating immune complexes (CIC)

which are thought to trigger such conditions. Europeans and Russians

have long preferred to use enzymes rather than NSAID's (aspirin,

ibuprofen, etc.) and corticosteroids ( e.g. prednisone) for injuries

as they have far fewer side-effects. For example, one European study

contrasted a proteolytic enzyme blend with diclofenac, an NSAID, and

found them similar in effect except that the enzymes had no side

effects. NSAID's hospitalize and kill many thousands annually.

Thins mucus. Conditions such as sinusitis, bronchitis, cystic

fibrosis, and other where mucus build up becomes a problem often

benefit dramatically from the use of proteolytic enzymes. A Japanese

study concluded " serrapaptase may exert a beneficial effect on mucus

clearance by reducing neutrophil numbers and altering the

viscoelasticity of sputum in patients with chronic airway diseases. "

A German study of 140 patients with airway obstructive disorders

such as bronchitis and sinusitis declared it almost 98% effective.

Increase potency of antibiotics. Serrapeptase, bromelain, and others

increase the blood and urine level of antibiotics resulting in

better effects than taking antibiotics alone.

Anti-Viral. Proteolytic enzymes attack the coating on viruses

rendering them harmless. This can be quite dramatic. For example, in

one study in the treatment of herpes zoster (shingles) an orally

administered proteolytic enzyme preparation was more effective than

the standard drug therapy (acyclovir.) In a study in patients with

hepatitis C, proteolytic enzymes were shown to be slightly superior

to alpha-interferon in improving laboratory values and symptoms.

Anti-Cancer. In 1906, ish physician, Beard, proposed that

something in the pancreas gland prevented cancer. He found that it

was the proteases that patrolled the body and stopped cancer from

developing. He made this observation by noting the similarity of

cancer to the undifferentiated cells of the chorion. In pregnancy it

stops growing when the pancreas gland kicks in. He used fresh

pancreas extract to cure many patients. Others over the years have

worked with this hypothesis to treat cancer with large doses of

pancreatic enzymes, often quite successfully. Dr.

in New York is currently undergoing large scale studies.

Others have found that proteolytic enzymes can dissolve the fibrin

coat on a tumor that hides it from the immune system and allows

natural killer cells to find and attack the tumor.

Blood Cleansing. Blood not only carries nutrients to our cells, it

also escorts garbage out. This can easily be seen in a darkfield

microscope where " dirty " blood shows up clearly. Proteolytic enzymes

clear out this " dirty " blood and the results are quick and dramatic

as seen in the microscope.

Analgesic. Serrapeptase reduces pain by blocking pain inducing

amines released from inflamed tissue.

Proteolytic enzymes are usually free of side effects but should not

be used with warfarin or other anticoagulants without a doctors'

supervision. They should also be used with caution in respiratory

conditions. One case involved a man who developed pneumonia when his

mucus became too thin.

iherb.com

has serrapeptase---

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