OT: Dr. Klinghardt Chronic infection and Lyme disease treatment protocol.

[Guest guest]

I'm currently working on neurotoxin elimination (curently using L Ornathine but

might add Beta Sitosterol), biofilm dissolution using nattokinase and

serropeptase with coconut oil and far infrared sauna.

Going back on EDTA as well since I took a break from it while I tried the detox

foot patches (gives me headaches) and the ionic foot baths.

Anyways this was a great post from Lyme Topics.

Brad

by Dietrich Klinghardt PhD/MD

A Few Words on Chronic Lyme Disease

Chronic Lyme disease is a fast-spreading problem in the USA and worldwide.

Classical Lyme disease is caused by a bacterial spirochete called Borrelia

burgdorferi. Conventional belief attributes Lyme Disease conveyance through tick

bites. Interestingly to the physician, more recent literature has shown that

also certain stinging flies, spiders and even some mosquitoes can infect humans

with this spirochete. This means that the disease vector can be more widespread

than previously anticipated. Lyme disease typically does not occur alone but

together with a number of co-infections. Classical Lyme disease, also known as

Borrelia, affects the immune system in predictable ways: it lowers the white

blood count and lessens the host's immunity. When the immune system becomes

dysfunctional, the patient then becomes infected with a multitude of secondary

bacterial, fungal, mycoplasmal and viral infections. A necessary co-condition

for the thriving of infectious organisms in the system is the presence of toxic

metals and other environmental toxins.

Chronic Lyme disease affects the immune system by rendering it blind to the

existence of Borrelia and other co-infections, including parasites. Lyme can

also affect the musculo-skeletal system with recurrent joint problems and

fibromyalgia type pain. A third presentation affects the central nervous system

with a multitude of related symptoms including emotional changes, psychiatric

problems and neurological problems, i.e. numbness, paralysis and strange

abnormal sensations. The area most commonly affected is the brain and the face

including the teeth, jawbone, ears and sinuses. The symptoms are caused by the

presence of neurotoxins that are created by the organisms. Neurotoxins are

usually peptides and other substances intended to alter the host's immune system

and make the host a comfortable environment for the proliferation of Borrelia

and the co-infections.

It is our experience that most Lyme patients, by the time the infection has

become chronic, have multiple parasites in their bowel. Co-infections from the

herpes virus family, sackie's viruses, influenza viruses, echo viruses and

the measles virus seem to be common. Frequently they also have one of several

mycoplasma species present and a multitude of other bacterial infections. Fungi

always thrive in a Lyme-infected patient. The treatment therefore needs to be

broad based and address all these co-infections in order to succeed. Treatment

for Lyme disease is often unsuccessful when it targets only the Lyme spirochete

but not the existing co-infections.

In Summary

1.

Borrelia affects the immune system by lessening the host's immunity.

2.

The host becomes a comfortable environment for co-infections.

3.

Treatment needs to be broad based, addressing co-infections.

A Few Words on the GI Tract

It is imperative to understand that the reservoir for many of these

co-infections is the gastrointestinal (GI) tract. It typically contains eight to

twelve pounds of living organisms. Many of these in the chronic Lyme patient are

parasites and abnormal bacteria, fungi, viruses and mycoplasmas, which set up

house in the gut and spread from there periodically to the other tissues.

In terms of sheer numbers, the GI tract is home to 100,000 billion

microorganisms at any one point in time. Considering that the average person has

approximately 10,000 billion mammalian cells in their body, one could say there

are 10 times more of 'them' than of 'us'. The monolayer of epithelial cells of

the intestinal mucosa constitutes the largest surface in the body that is

exposed to the environment. In other words, one cell layer separates you from

the outside world in your GI tract! It is estimated that this mucosal surface is

equal to the size of two tennis courts. The gut can turn into a storehouse of

infectious organisms and must be understood in order to be treated successfully.

A Few Words on Pharmax Nutriceuticals

I have chosen the nutriceuticals from Pharmax LLC for dealing with many of the

issues outlined in this article.

Firstly, the company is co-owned by brilliant researchers who have spent years

in the trenches as research microbiologists.

Secondly, they manufacture their own nutriceuticals with strict quality

controls, as reflected in their ISO 9001 certification. Most companies merely

repackage products manufactured elsewhere. As a prime manufacturer, Pharmax

produce their own base materials and their unique freeze-drying technology

enables the company to use a solvent-free manufacturing process.

Thirdly, I find the products are pure and intelligently designed.

Specific Treatment for Co-infections in the GI Tract

1.

Freeze Dried Garlic (700mg freeze dried garlic concentrate [Allium

sativum] per capsule)

The active antimicrobial in garlic is allicin (Ankri & Mirelman, 1999). It has

MIC (minimum inhibitory concentration) values very similar to antibiotics and

antifungals for their prospective targeted organism. For example, the MIC for

Staphylococcus aureus is 26, Escherichia coli is 44 and Candida albicans is 36

(these are all astoundingly low numbers, indicating that allicin is a potent

antibiotic or antifungal for these organisms!). Allicin also kills protozoa's

such as Cryptosporidium, E. histolytica (Mirelman et al., 1987) and Giardia

( et al., 2000). Allicin is effective against viruses such as the

Rotavirus (Blake, 1983), Influenza virus (Fenwick & Hanley, 1985) and viruses

from the herpes family (i.e. HHV-6 and others), to name just a few (Tsai et al.,

1985). Yet it is not cytotoxic and does not harm the beneficial bacteria in the

gut, i.e. the lactic acid bacteria such as Lactobacillus acidophilus and

Bifidobacterium bifidum (Rees et al., 1993).

In treatment, I advise 2 capsules after each meal - a total of between 4 and 6

capsules each day.

1.

AlliCinn (500mg freeze dried garlic concentrate [Allium sativum], 200mg

freeze dried cinnamon bark oil concentrate [Cinnamomum cassia] per capsule)

If tolerated, it is preferred to use the Pharmax product called AlliCinn. The

cinnamaldehydes have a wonderful antibacterial action (Chang et al., 2001).

However, sometimes a patient gets cramps as a side effect and cannot tolerate

the cinnamon oils. In that case we either discontinue this product, or add two

drops of peppermint oil every time the patient takes a capsule of the AlliCinn.

The peppermint oil completely prevents the cramping and therefore makes the

AlliCinn well tolerated.

I generally give 2 capsules, three times a day after a meal.

1.

Antimicrobial Complex (200mg barberry bark standardized extract [berberis

vulgaris], 50mg goldenseal standardized extract [Hydrastis canadensis], 100mg

freeze dried garlic concentrate [Allium sativum], 50mg freeze dried wormwood oil

concentrate [Artemesia absinthium] per capsule)

We also include the Antimicrobial Complex to treat other often undefined

bacterial co-infections. Artemesia absinthium has been shown to be an ideal

agent to treat Babesia, which is one of the organisms frequently present as a

co-infection with Lyme disease (it is an intracellular parasite similar to

malaria). Berberis vulgaris is a potent antibacterial agent (Ruggeri et al.,

1991).

I generally advise one capsule, three times a day with meals.

1.

Intestinal Purifier (3g psyllium husk, 1.75g FOS, 1g L-glutamine, 2g

resistant starches, 2g freeze dried prune puree and 0.25g quercetin per 10g

scoop)

We recommend a fiber laxative along with the treatment so that the dead

microorganisms can be carried out of the system more easily. To this end, we use

Pharmax's product Intestinal Purifier, which acts like a stool expander. It

turns the stool into a brush, cleaning the bowel wall of the residues of dead or

ailing microorganisms and parasites.

I give one scoop (10 grams) mixed with water or juice and taken with a meal.

1.

HLC High Potency (4 billion Lactobacillus acidophilus and Bifidobacterium

bifidum per capsule)

To replace the normal bowel flora, we always recommend Pharmax's human lactic

commensals, i.e. HLC High Potency for bowel restoration.

I recommend 1 - 2 capsules after each meal.

1.

Intestinal Complex (150mg slippery elm bark extract 4:1 [ulmus fulva],

100mg marshmallow root extract 4:1 [Althaea officinalis], 85mg camomile flower

standardized extract [Matricaria recutita], 100mg marigold flower extract 4:1

[Calendula officinalis], 50mg licorice root standardized extract [Glycyrrhiza

glabra], 50mg gamma-oryzanol per capsule).

In addition, we also include the Intestinal Complex. The slippery elm bark

prevents the reattachment of freshly hatched worms to the bowel wall. The other

ingredients have a synergistic effect and a relative laxative effect that is

desired during this phase of the treatment period.

I give one capsule, three times a day with meals.

1.

Permeability Complex I (1,500mg FOS, 1,000mg L-glutamine, 500mg aspartic

acid, 500mg L-arginine, 20mg magnesium, 330mg vitamin C, 100mg N-acetyl

glucosamine [NAG], 100mg quercetin, 15mg zinc, 20mg essential oil of ginger

[Zingiber officinale], 5,000iu vitamin A, 100iu vitamin E)

Provides luminal nutrients for a healthy GI mucosa (Souba, 1990).

I advise 1 -2 scoops (5 - 10 grams), three times a day with meals

Specific Treatment for Borrelia, Ehrlichiosis, Babesia and Mycoplasma Infections

1.

Freeze Dried Garlic (700mg freeze dried garlic concentrate [Allium

sativum] per capsule)

For the specific treatment of Borrelia, we use Freeze Dried Garlic in the dose

already recommended. The garlic will first eliminate the microorganisms and

parasites in the bowel before the allicin and its breakdown products can be

active in the connective tissue and later also in the brain. Allicin, the

primary active ingredient, has been shown to cross the blood-brain barrier and

it is a surprisingly effective antimicrobial agent against the Lyme spirochete

even in the brain and the CNS.

However, high doses are recommended, usually upwards from 5,600mg total daily

intake given in divided doses every 6 hours. This translates to 4 capsules QID.

The way I often titrate the individual dose is by body odor. When a patient gets

a slight garlic body odor, the desired dosage is reached.

1.

Pyloricin (700mg total capsule fill of freeze dried oregano oil

concentrate [Thymus capitus], freeze dried clove oil concentrate [syzygium

aromaticum], freeze dried ginger oil concentrate [Zingiber officinale] and

freeze dried wormwood oil concentrate [Artemesia absinthium])

Babesia, Ehrlichiosis and Borrelia are often sensitive to the product Pyloricin.

The most effective ingredient here is again oil of artemesia for its tremendous

effect on Babesia. The second most important ingredient is the oregano oil,

which we found to be most effective against Borrelia, Babesia, Ehrlichiosis and

Mycoplasmas. Clove oil and ginger have a synergistic effect.

I usually give one capsule TID taken on an empty stomach along with the rest of

the program. (Again, if the patient experiences cramping as a result of the

treatment, a drop or two of peppermint oil in a little bit of water taken at the

same time will alleviate the symptoms. Peppermint also potentiates the effect of

all the other essential oils.)

Specific Treatment for Yeast Infections

1.

Freeze Dried Garlic (700mg freeze dried garlic concentrate [Allium

sativum] per capsule)

In my experience, freeze dried garlic is most often sufficient in eliminating

yeasts, which is consistent with the recent literature (Ghannoum, 1988; Yoshida

et al., 1987; Adetumbi et al., 1986; Sandhu et al., 1980).

I give 2 capsules TID with meals. Other beneficial products can be added to the

protocol such as Colon Guard and Caprylate Complex.

1.

Colon Guard (350mg freeze dried garlic concentrate[Allium sativum], 60mg

freeze-dried cinnamon bark oil concentrate[Cinnamomum cassia], 150mg magnesium

caprylate, 215mg calcium caprylate per capsule)

Caprylic acid has been shown for many years to be a very active anti-fungal

along with freeze-dried garlic (Yoshida et al., 1987) and cinnamon oil (Singh et

al., 1995).

I give 2 capsules with each meal.

1.

Caprylate Complex (500mg magnesium caprylate and calcium caprylate per

capsule)

I also use Caprylate Complex.

I give one capsule three times per day with meals along with Colon Guard if

fungal infection predominates.

Summary of the Protocol for Co-infections

1.

Freeze Dried Garlic or AlliCinn: 2 capsules three times daily with meals.

2.

Antimicrobial Complex: One capsule three times daily with meals.

3.

Pyloricin: One capsule twice daily with meals.

4.

HLC High Potency: One capsule twice daily with meals.

5.

Intestinal Complex: One capsule three times daily with meals.

6.

Intestinal Purifier: One 10g scoop taken once daily with a meal.

7.

Colon Guard: 2 capsules three times daily with meals.

8.

Caprylate Complex: One capsule three times daily with meals.

9. Permeability 1 One to 2 scoops twice daily with meals

1. Detoxification

Heavy metals and environmental toxins change the inner environment of the

patient. This milieu is a necessary sine qua non for the presence of harmful

microorganisms and the inability of the immune system to deal with them.

Therefore, every patient with chronic Lyme Disease has to be detoxified. We have

developed new simple steps in the elimination of toxic metals from the body. We

are using a product that contains a large amount of branched chained amino acids

and is most effective in detoxifying heavy metals from the central nervous

system. Also, glutathione is critically important and must be added.

Detoxification Treatment - One Year Duration

1.

BMI Balance (100g chromium, 23.75g whey protein concentrate, 1.5g

conjugated linolenic acid, 225mg L-carnitine, 1.2g FOS per 30g scoop)

It is made from whey protein, which contains these important amino acids in

ideal amounts.

I get patients to take 30g per meal.

1.

Glutathione Precursors (300mg N-acetyl cysteine, 200mg glutamic acid,

200mg alpha-lipoic acid per capsule)

Glutathione is needed by the cell to detoxify itself from heavy metals and other

toxins (Srivastava et al., 2002). It is also an effective antiviral agent

(e et al., 2002). Glutathione Precursors contains alpha lipoic acid and

N-acetyl cysteine, which are effective heavy metal detox agents on their own

(, 1998; Hagen et al., 2002).

Glutathione Precursors is always advised. I give one to 3 capsules per day to

raise glutathione levels.

Mineral Replacement Treatment

Metals are bound to various structures in the connective tissue, the cell walls

and the surfaces of intracellular organelles. They are in the cell on binding

sites that are usually reserved for other beneficial minerals. Only when the

body is depleted of minerals do heavy metals permanently attach to those sites.

In order to displace the heavy metals from those binding sites, the system has

to be saturated with beneficial minerals.

1.

Trace Mineral Complex (20mg iron, 10mg manganese, 200 & #61549;g chromium,

200 & #61549;g selenium, 200 & #61549;g iodine, 1mg copper, 25mg zinc, 200 & #61549;g

molybdenum, 100 & #61549;g vanadium, 2mg boron, 450mg vitamin C, 25 & #61549;g

nickel, 35 & #61549;g of silica per capsule - all listed in elemental amounts).

I recommend one capsule with each meal for 6 to 12 months.

1.

Selenium CWS (100g elemental selenium per drop)

Selenium is our prime agent to treat the chronic viral co-infections (Beck,

2001; Beck et al., 2001). Selenium works like a birth control pill for viruses.

It stops viral replication. However, the dosage needed is higher than the normal

recommended dosages of selenium. The patient should have a total input of

selenium of about 1,200g per day to reach an effective antiviral level. This

should be sustained no longer than 6 months before the maintenance dose of 200

to 400g is reached. We use the Selenium CWS, which is dropped over the patient's

food. When minerals or vitamins are taken with food we have observed that the

patient hardly ever becomes allergic to them. When they are taken away from food

the patient often becomes sensitized to it.

I advise 12 drops per day over food for 6 months.

1.

Trace Mineral CWS (50g chromium, 50g selenium, 50g molybdenum, 50g boron,

50mg manganese, 50g of iodine per 4 drops - all listed in elemental amounts.)

To increase the mineral uptake, we also use the Trace Mineral CWS, which does

not contain zinc and is therefore ideal to increase the mineral levels without

increasing the zinc. Zinc is a potentiating agent for mercury toxicity and has

to be dosed carefully.

I typically advise adding 5 to 10 drops of the Trace Mineral CWS, ideally taken

in salad dressing or soup, to the 3 capsules of the Trace Mineral Complex.

1.

Mag:Cal Citrate (75mg calcium, 75mg magnesium, 100 & #61549;g boron, 15mg of

vitamin B6 per capsule - the minerals are listed in elemental amounts.)

Most patients with heavy metal toxicity need extra calcium and magnesium.

I typically give 2 to 4 capsules of the Mag:Cal Citrate, to be taken with the

evening meal.

Summary of the Detoxification and Mineral Replacement Protocols

1.

BMI Balance: One scoop (30grams) per meal replacement, with water or milk

for one year.

2.

Glutathione Precursors: One capsule per day, taken with food for one year.

3.

Trace Mineral Complex: One capsule with each meal for 6 to 12 months.

4.

Selenium CWS: 12 drops per day dropped over food, for 6 months.

5.

Trace Mineral CWS: 5 to 10 drops with each capsule dose of the Trace

Mineral Complex.

6.

Mag:Cal Citrate: 2 to 4 capsules with the evening meal.

Treating Neurological Symptoms

When the patient's presentation is primarily neurological, we have to pay

attention to the fatty acids. Fatty acids make up 80% of the weight of the

brain, and are necessary to maintain healthy barriers within the brain. The cell

walls are made up to a large degree of lipids that can only be intact if a

patient has a good input of lipids on a daily basis. Fish oil and fish oil

derivatives are the most important component to be observed in the treatment of

Lyme Disease.

My current most popular way of dosing this is to use DriCelle EFA 950.

1.

DriCelle EFA 950 (300mg DHA, 400mg EPA, 100mg GLA, 150mg ALA per teaspoon)

This equals the total input of EPA of about 800mg per day. This is also an

effective dose in the treatment of cancer and extremely effective in stopping

the replication of viruses. Therefore it is an important part of the antiviral

program.

I recommend one half-teaspoon DriCelle EFA 950 QID

It is best to test the different oil products with ART or EAV, or through

Ared-cell Membrane Fatty Acid Test. The current " Body Bio Fatty Acid Test " is

also good. The test, however, overlooks the fact that we like patients to have

extremely high levels of EPA and DHA in the abnormal range, which is protective

against viral replication and neurological damage from Lyme disease.

Whenever the patient takes oils that are meant to be absorbed into the blood and

to then travel from there into the brain, the oil absorption should be enhanced

by giving an enzyme with a high amount of lipase.

We therefore recommend that the patient take the product called:

1.

Pure Pancreatin (700mg vegetable pancreatin per capsule)

Each capsule contains 11,200 lipase USP units.

I therefore recommend that patients should take 1 to 2 capsules every time one

of the essential oils from Pharmax is used.

Summary for Treating Neurological Symptoms

1.

DriCelle EFA 950 One half teaspoon, four times a day in water or juice

with a meal.

2.

Pure Pancreatin One to 2 capsules every time DriCelle EFA 950 is taken.

For severe neurological symptoms such as paralysis, check for the presence of a

co-infection called Bartonella henselae (also called cat scratch disease). This

illness responds to high doses of antibiotics, which should be the preferred

treatment of choice. We have been treating Lyme Disease with the above protocols

plus the addition of bee venom therapy two to three times a week for a prolonged

period of time, and have often seen good and lasting results with this approach.

For the treatment of Babesiosis, we have sometimes to include the antibiotic

Mepron for 3 to 6 weeks.

Treating Immune System Symptoms

If the immune system symptoms predominate, I like to include:

1.

Ginseng Combination (350mg Siberian ginseng root, 350mg Korean panax

ginseng root per capsule)

This has a multitude of beneficial effects on the immune system.

I give 2 capsules BID with meals.

1.

Immusol (2ml Echinacea angustafolia, 2ml Echinacea purpurea, 2ml

Elderberry liquid extract, 0.3ml CLA, 300mg Vitamin C, 10mg Zinc)

A combination of immune stimulating factors, which is also excellent (Coeugniet

& Elek, 1987; Craig, 1999).

I give 3 teaspoons daily with food.

Summary for Treating Immune Symptoms

1.

Ginseng Combination Two capsules BID with meals

2.

Immusol Three teaspoons daily with food.

Neurotoxin Binding

Neurotoxins are constantly excreted by the body through the liver into the bile

ducts and from there into the small intestines. Neurotoxins have a high affinity

for nervous system tissue. The small intestines are lined with nerve endings. On

the way through the small intestine, most neurotoxins are re-absorbed by the

nerve endings and travel from there to the spinal cord and back up into the

brain.

They are on an endless rotation through these different systems without leaving

the body. It has been shown that several substances can intercept the

neurotoxins on their way down and bind them in the stool so they are excreted.

1.

Beta Sitosterol (100mg b-sitosterol per capsule)

Most commonly we use Beta Sitosterol for this purpose.

My current dosage recommendation is that the patient takes 1 to 2 capsules, four

times a day between meals. It is good to take 2 of these doses at night since

most of the detox functions happen at night. This product should be given for 3

weeks on, 3 weeks off, for 6 to 12 weeks.

1.

Liver Support and Detoxification (200mg choline bitartrate, 100mg milk

thistle seed standardized extract [silybum marianum], 25mg inositol, 25mg

L-methionine, 80mg turmeric standardized extract [Curcuma longae], 50mg licorice

root standardized extract [Glycyrrhiza glabra], 50mg calcium glucarate, 25mg

indole-3-carbinol, 50 & #61549;g biotin, 25mg limonene, 25mg L-glycine per

capsule)

To increase the liver detoxifying abilities we include the product Liver Support

and Detoxification at the suggested dosage. This product provides a

comprehensive combination of nutrients and phytochemicals with known activity in

stimulating liver function, with special emphasis on detoxification reactions.

While both Phase 1 and Phase 2 reactions are stimulated, there is a greater

qualitative stimulation of Phase 2, providing a net gain in elimination of toxic

materials, which then sets up a gradient of drainage from other tissues. Take 2

capsules BID with meals.

Summary for clearing Neurotoxins

1.

Beta Sitosterol One to 2 capsules four times a day between meals

2.

Liver Support and Detoxification Two capsules per day with a meal.

Laboratory Diagnosis

Lyme Disease is a chronic disease that is responsible for a multitude of

illnesses including chronic low back pain, migraine headache, fibromyalgia,

chronic fatigue and even some cancers. It is most often misdiagnosed as another

illness. For the diagnosis, we are currently recommending the lymphocyte

transformation test that is not available in the USA. Here, the most successful

diagnostic procedure is the direct proof of the microbial presence through phase

contrast dark field microscopy after using species-specific fluorescent stain

(Bowen Research laboratory). Other tests used: Western Blot Test, PCR Test

and Lymphocyte Transformation Test.

Optimal Diet and The Four Pillars of Nutrient Supplementation from Pharmax

Multivitamins and minerals, fatty acids, antioxidants and probiotics form the

Four Pillars of the Pharmax approach, and these along with an optimal diet form

the necessary underlying base upon which sound treatment is built. However, as

long as a significant amount of parasites and microorganisms are present in the

gut, these also are fed with the multivitamins approach.

Therefore we usually suggest an initial three-week approach of using the

anti-infectious agents and bowel restoration products only to reduce the amount

of pathogenic flora in the gut before starting on the multivitamins,

antioxidants and other rich nutrient sources. After the initial three weeks of

antimicrobial use, the following Four Pillars can be brought into play:

Summary of the Four Pillars of Supplementation (see Pharmax flier)

1.

Vitamins and Minerals:

Multivitamin & Mineral (adult formula) Two capsules per day with food

or

Multi Omega Plex Two scoops per day with food.

(The Multi Omega Plex combines vitamins and minerals with essential fatty acids.

Therefore the vitamin and mineral pillar and the fatty acid pillar are combined

in one product).

Vitamin C Powder One gram per day with food.

Natural E 300 One capsule per day with food

1.

Fatty Acids

DHA/EPA 1000 Five grams per day with food

or

EFA 950 Five grams per day with food

or

Omega 3:6:9 Ad lib with food

1.

Antioxidants

Endogenous Antioxidants One capsule per day with food

or

Glutathione Precursors One capsule per day with food

plus

Carotenoid Complex Two capsules per week with food

plus

Phyto Antioxidants Two capsules per week with food

1.

Probiotics & Prebiotics:

HLC High Potency Two capsules per day with food

The Use of Antibiotics in Treating Lyme Disease

The recommended medical treatment for Lyme disease and the associated

co-infections is the use of antibiotics. The typical treatment of mycoplasma

infections takes several six-week cycles of high doses of antibiotics. We

currently believe that the approach using natural antibiotics and antimicrobials

has superior long-term effects. However sometimes the patient cannot respond to

a particular approach and another approach has to be chosen. We occasionally

have to include the use of intravenous antibiotics.

Other 'alternative' treatments include the use of microcurrent, ozone therapy,

ultraviolet blood irradation, hyperbaric oxygen, bee venom therapy, ozone sauna,

acupuncture and colon hydrotherapy.

We recommend the following web sites for further information:

1.

www.Lymenet.com (antibiotic schedules)

2.

www.chronicneurotoxins.com (neurotoxin binding agents)

3.

www.neurotherapy.com (bee-venom therapy)

4.

www.pharmaxllc.com (nutriceuticals)

References

Adetumbi, M. et al., (1986) Allium sativum (garlic) inhibits lipid synthesis by

Candida albicans.

Antimicrob Agents Chemother 30 (3): 499-501.

Ankri, S. & Mirelman, D. (1999) Antimicrobial properties of allicin from garlic.

Microbes and Infection. 2, 125-129

Beck M.A. (2001) Antioxidants and viral infections: host immune response and

viral pathogenicity. J Am Coll Nutr 20 (5 Suppl): 384S-388S Discussion 396S-397S

Beck M.A. et al., (2001) Selenium deficiency increases the pathology of an

influenza virus infection. FASEB J 15(8): 1481-3

Blake, K. (1983) Onion and garlic oils inhibit tumour promotion. Carcinogenesis

4, (8) 1063-1065

Chang S.T. et al., (2001) Antibacterial activity of leaf essential oils and

their constituents from

Cinnamomum osmophloeum. J Ethnopharmacol. 2001 Sep; 77(1):123-7.

e S.F. et al., (2002) Changes in the activities of antioxidant enzymes in

response to virus infection and hormone treatment. Physiol Plant.

114(2):157-164.

Coeugniet E.G. & Elek E. (1987) Immunomodulation with Viscum album and Echinacea

purpurea extracts. Onkologie. 10 (3 Suppl): 27-33

Craig W.J. (1999) Health-promoting properties of common herbs. Am J Clin Nutr 70

(3 Suppl) 491S-499S

Fenwick, G.R. & Hanley, A.B. (1985) The genus Allium. CRC. Rev. Food Sci. Nutr.

22, 199-377

Ghannoum M.A. (1988) Studies on the anticandidal mode of action of Allium

sativum (garlic). J Gen Microbiol. 134 (Pt 11):2917-24.

Hagen T.M. et al., (2002) Mitochondrial Decay in the Aging Rat Heart: Evidence

for Improvement by Dietary Supplementation with Acetyl-l-Carnitine and/or Lipoic

Acid. Ann N Y Acad Sci 959:491-507

, J.C. et al. (2000) The microaerophilic flagellate Giardia intestinalis:

Allium sativum (garlic) is an effective antigiradial. Microbiology 146,

3119-3127

G.S. (1998) Clinical applications of N-acetylcysteine. Altern Med Rev 3

(2):114-27

Mirelman, D. et al. (1987) Inhibition of growth of Entamoeba histolytica by

allicin, the active principle of garlic extract (Allium sativum). Journal of

Infectious Diseases. 156(1) 243-244

Rees, L.P. et al., (1993) A quantitative assessment of the anti-microbial

activity of garlic (Allium sativum). World Journal of Microbiology and

Biotechnology. 9, 303-307

Ruggeri P. et al., (1991) Chemical composition and antimicrobial activity of two

Peruvian plants Boll Soc Ital Biol Sper 67(10-11):955-60

Sandhu D.K. et al., (1980) Sensitivity of yeasts isolated from cases of

vaginitis to aqueous extracts of garlic. Mykosen. 23(12):691-8.

Singh H.B. et al., (1995) Cinnamon bark oil, a potent fungitoxicant against

fungi causing respiratory

tract mycoses. Allergy 50(12):995-9

Souba W.W. (1990) The role of glutamine in maintaining a healthy gut and

supporting the metabolic response to injury and infection. J Surg Res

48(4):383-91

Srivastava S.K. et al., (2002) Role of glutathione conjugate efflux in cellular

protection against benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage. Mol

Carcinog. 33(3):156-62.

Tsai Y. et al., (1985) Antiviral properties of garlic: in vitro effects on

influenza B, herpes simplex and coxsackie viruses. Planta Med. Oct;(5):460-1.

Yoshida S. et al., (1987) Antifungal activity of ajoene derived from garlic.

Appl Environ Microbiol. 53(3):615-7.